Letm1 exchanges protons (mitochondrial intermembrane space) for calcium (mitochondrial matrix)

Stable Identifier
R-MMU-8951834
Type
Reaction [transition]
Species
Mus musculus
Compartment
mitochondrial inner membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Letm1 exchanges protons (mitochondrial intermembrane space) for calcium (mitochondrial matrix)
Letm1 exchanges mitochondrial matrix calcium for protons in the intermembrane space (Shao et al. 2016). Knockdown of Letm1, however, caused a reduction in mitochondrial calcium uptake and proton extrusion at low cytosolic calcium concentration (Jiang et al. 2013).
Literature References
PubMed ID Title Journal Year
23716663 Letm1, the mitochondrial Ca2+/H+ antiporter, is essential for normal glucose metabolism and alters brain function in Wolf-Hirschhorn syndrome

Clapham, DE, Zhao, L, Clish, CB, Jiang, D

Proc. Natl. Acad. Sci. U.S.A. 2013
27669901 Leucine zipper-EF-hand containing transmembrane protein 1 (LETM1) forms a Ca(2+)/H(+) antiporter

Ji, Y, Shao, J, Yang, X, Fu, Z, Ding, Z, Guan, X, Shen, Y, Cong, Y, Guo, S

Sci Rep 2016
Participants
Input
Output
Catalyst Activity

calcium:proton antiporter activity of Letm1 hexamer [mitochondrial inner membrane]

Physical Entity
Letm1 hexamer [mitochondrial inner membrane] (Mus musculus)
Activity
calcium:proton antiporter activity (GO:0015369)
Orthologous Events
LETM1 exchanges protons (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Homo sapiens)
Authored
May, B  (2016-11-28)
Reviewed
Drago, I  (2017-01-21)
Created
May, B  (2016-12-11)
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