Stat3 binds to p-Y-Il23r from Il23:Il23 receptor

Stable Identifier
R-MMU-8950442
Type
Reaction [omitted]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Stat3 binds to p-Y-Il23r from Il23:Il23 receptor

Signal transducer and activator of transcription 3 (Stat3) binds Interleukin-23 receptor (Il23r), after cytokine-receptor interaction, for both canonical and non-canonical Stat3 activation (Dumoutier et al. 2009, Floss et al. 2013). This is a black box event because Stat3 binding as a consequence of Interleukin-23 stimulation has not been directly demonstrated.

Literature References
PubMed ID Title Journal Year
19632985 New activation modus of STAT3: a tyrosine-less region of the interleukin-22 receptor recruits STAT3 by interacting with its coiled-coil domain

Dumoutier, L, de Meester, C, Tavernier, J, Renauld, JC

J. Biol. Chem. 2009
23673666 Identification of canonical tyrosine-dependent and non-canonical tyrosine-independent STAT3 activation sites in the intracellular domain of the interleukin 23 receptor

Floss, DM, Mrotzek, S, Klöcker, T, Schröder, J, Grötzinger, J, Rose-John, S, Scheller, J

J. Biol. Chem. 2013
Participants
Orthologous Events
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