Il27ra binds Jak1

Stable Identifier
R-MMU-8950409
Type
Reaction [binding]
Species
Mus musculus
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Il27ra binds Jak1
The cytoplasmic domain of Interleukin-27 receptor subunit alpha (Il27ra) has a Box-1 motif which is important for binding to Janus kinases family of proteins (Sprecher et al. 1998). Mouse Interleukin-27 receptor alpha (Il27ra, WTX-1) has been shown to directly associate with Tyrosine-protein kinase JAK1 (Jak1) as well as Signal transducer and activator of transcription 1-alpha/beta (Stat1) (Takeda et al. 2003). Coimmunoprecipitation studies and pull-down assays suggest that the Il27ra directly associates with Jak1 and that one of its tyrosin residues provides a docking site for Stat1 when phosphorylated.
Literature References
PubMed ID Title Journal Year
12734330 Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment

Mak, TW, Ishibashi, T, Takeda, A, Hanada, T, Yoshida, H, Yoshimura, A, Hamano, S, Yamanaka, A

J. Immunol. 2003
9600072 Cloning and characterization of a novel class I cytokine receptor

Foster, DF, Sprecher, CA, Schrader, SK, Whitmore, TE, Baumgartner, JW, Presnell, SR, Yamagiwa, T, Grant, FJ, O'Hara, PJ

Biochem. Biophys. Res. Commun. 1998
Participants
Input
Output
Orthologous Events
IL27RA binds JAK1 (Homo sapiens)
Authored
Duenas, C  (2016-12-02)
Reviewed
van de Vosse, E  (2017-05-12)
Created
Duenas, C  (2016-12-02)
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