Il27ra binds Jak1

Stable Identifier
R-MMU-8950409
Type
Reaction [binding]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Il27ra binds Jak1

The cytoplasmic domain of Interleukin-27 receptor subunit alpha (Il27ra) has a Box-1 motif which is important for binding to Janus kinases family of proteins (Sprecher et al. 1998). Mouse Interleukin-27 receptor alpha (Il27ra, WTX-1) has been shown to directly associate with Tyrosine-protein kinase JAK1 (Jak1) as well as Signal transducer and activator of transcription 1-alpha/beta (Stat1) (Takeda et al. 2003). Coimmunoprecipitation studies and pull-down assays suggest that the Il27ra directly associates with Jak1 and that one of its tyrosin residues provides a docking site for Stat1 when phosphorylated.

Literature References
PubMed ID Title Journal Year
9600072 Cloning and characterization of a novel class I cytokine receptor

Sprecher, CA, Grant, FJ, Baumgartner, JW, Presnell, SR, Schrader, SK, Yamagiwa, T, Whitmore, TE, O'Hara, PJ, Foster, DF

Biochem. Biophys. Res. Commun. 1998
12734330 Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment

Takeda, A, Hamano, S, Yamanaka, A, Hanada, T, Ishibashi, T, Mak, TW, Yoshimura, A, Yoshida, H

J. Immunol. 2003
Participants
Orthologous Events
Authored
Reviewed
Created