Interleukin 27 translocates to the extracellular region

Stable Identifier
R-MMU-8950248
Type
Reaction [omitted]
Species
Mus musculus
Compartment
ReviewStatus
5/5
General
SVG |   | PPTX  | SBGN
Interleukin 27 translocates to the extracellular region
Experiments where cells were transfected with mouse Interleukin-27 subunit beta (Ebi3) and Interleukin 27 subunit alpha(Il27) showed that Il27 can be secreted as a monomer, whereas Ebi3 is secreted only as a heterodimer of Ebi3 and Il27 (Shimozato et al. 2009). Il27 monomers may antagonize cytokine signaling through Interleukin-6 receptor subunit beta (IL6ST, gp130) and the Interleukin-6 mediated production of Interleukin-17 and Interleukin-10 (Stumhofer et al. 2010).
Literature References
PubMed ID Title Journal Year
21057510 A role for IL-27p28 as an antagonist of gp130-mediated signaling

Goenka, R, Spudy, B, Chen, Y, Grötzinger, J, Elloso, MM, Hunter, CA, Tait, ED, Saris, CJ, Hosken, N, Fielding, CA, Cua, DJ, Rose-John, S, Stumhofer, JS, Cancro, MP, Jones, SA, Jones, ML, Levin, SD, Quinn, WJ, O'Hara, AC

Nat. Immunol. 2010
19740343 The secreted form of p28 subunit of interleukin (IL)-27 inhibits biological functions of IL-27 and suppresses anti-allogeneic immune responses

Li, Q, Sato, A, Tagawa, M, Chiyo, M, Ma, G, Kawamura, K, Shimozato, O

Immunology 2009
Participants
Orthologous Events
Authored
Reviewed
Created
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