Interleukin 27 translocates to the extracellular region

Stable Identifier
R-MMU-8950248
Type
Reaction [omitted]
Species
Mus musculus
Compartment
cytosol, extracellular region
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Interleukin 27 translocates to the extracellular region
Experiments where cells were transfected with mouse Interleukin-27 subunit beta (Ebi3) and Interleukin 27 subunit alpha(Il27) showed that Il27 can be secreted as a monomer, whereas Ebi3 is secreted only as a heterodimer of Ebi3 and Il27 (Shimozato et al. 2009). Il27 monomers may antagonize cytokine signaling through Interleukin-6 receptor subunit beta (IL6ST, gp130) and the Interleukin-6 mediated production of Interleukin-17 and Interleukin-10 (Stumhofer et al. 2010).
Literature References
PubMed ID Title Journal Year
21057510 A role for IL-27p28 as an antagonist of gp130-mediated signaling

Stumhofer, JS, Tait, ED, Quinn, WJ, Hosken, N, Spudy, B, Goenka, R, Fielding, CA, O'Hara, AC, Chen, Y, Jones, ML, Saris, CJ, Rose-John, S, Cua, DJ, Jones, SA, Elloso, MM, Grötzinger, J, Cancro, MP, Levin, SD, Hunter, CA

Nat. Immunol. 2010
19740343 The secreted form of p28 subunit of interleukin (IL)-27 inhibits biological functions of IL-27 and suppresses anti-allogeneic immune responses

Shimozato, O, Sato, A, Kawamura, K, Chiyo, M, Ma, G, Li, Q, Tagawa, M

Immunology 2009
Participants
Input
Output
Orthologous Events
IL27 translocates from the cytosol to the extracellular space (Homo sapiens)
Authored
Duenas, C  (2016-12-02)
Reviewed
van de Vosse, E  (2017-05-12)
Created
Duenas, C  (2016-12-02)
Cite Us!