Reactome | IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 [plasma membrane]

IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 [plasma membrane]

Stable Identifier

R-MMU-8950116

Type

Complex

Species

Mus musculus

Compartment

plasma membrane

Locations in the PathwayBrowser

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General

This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Participants

components

IL12A:IL12B [extracellular region] (Mus musculus)
IL12RB1:TYK2:IL12RB2:JAK2 [plasma membrane] (Mus musculus)

Participates

as an input of

JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated (Mus musculus)
Interleukin-12 dissociates from Interleukin-12 receptor (Mus musculus)
IL12 bound to IL12R internalises (Mus musculus)

as an output of

Interleukin-12 binds Interleukin-12 receptor (Mus musculus)
IL12 bound to IL12R internalises (Mus musculus)

Inferred From

IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 [cytosol] (Homo sapiens)

IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 [plasma membrane] (Homo sapiens)

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