There is experimental evidence of the association of mouse Non-receptor tyrosine-protein kinase Tyk2 (Tyk2) with mouse Interleukin-12 receptor beta-1 chain (Il12rb1) by means of the Box1 motif. In the experiment mouse Il12rb1 coimmunoprecipitated with mouse Tyk2. The Box 1 motif located in the intracellular domain of the receptor chain Il12rb1 is essential for binding. In the absence of Tyk2, Il12rb1 binds to Jak1 (Floss et al. 2016).