Il12rb1 binds Tyk2

Stable Identifier
R-MMU-8950034
Type
Reaction [binding]
Species
Mus musculus
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Il12rb1 binds Tyk2
There is experimental evidence of the association of mouse Non-receptor tyrosine-protein kinase Tyk2 (Tyk2) with mouse Interleukin-12 receptor beta-1 chain (Il12rb1) by means of the Box1 motif. In the experiment mouse Il12rb1 coimmunoprecipitated with mouse Tyk2. The Box 1 motif located in the intracellular domain of the receptor chain Il12rb1 is essential for binding. In the absence of Tyk2, Il12rb1 binds to Jak1 (Floss et al. 2016).
Literature References
PubMed ID Title Journal Year
27193299 Defining the functional binding sites of interleukin 12 receptor β1 and interleukin 23 receptor to Janus kinases

Lamertz, L, Floss, DM, Hermanns, H, Scheller, J, Schröder, J, Mrotzek, S, Strobl, B, Klöcker, T

Mol. Biol. Cell 2016
Participants
Input
Output
Orthologous Events
IL12RB1 binds TYK2 (Homo sapiens)
Authored
Duenas, C  (2016-12-02)
Reviewed
van de Vosse, E  (2017-05-12)
Created
Duenas, C  (2016-12-02)
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