Lsr trimer binds VLDL

Stable Identifier
R-MMU-8933295
Type
Reaction [binding]
Species
Mus musculus
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Lsr trimer binds VLDL
The human lipolysis-stimulated lipoprotein receptor (LSR, LISCH) probably plays a role in the clearance of triglyceride-rich lipoproteins from blood, allowing their subsequent uptake into cells. Its affinity is highest for those lipoproteins most susceptible to lipolysis such as chylomicrons, LDL and VLDL. Human LSR function is inferred from mouse Lsr expression, functional and gene silencing studies (Yen et al. 1999, Mesli et al. 2004, Yen et al. 2008). Lsr inactivation in mice during embryogenesis resulted in death and indicated expression of Lsr was critical for liver and embryonic development (Mesli et al. 2004). This reaction shows LSR binding LDL.
Literature References
PubMed ID Title Journal Year
18644789 Lipolysis stimulated lipoprotein receptor: a novel molecular link between hyperlipidemia, weight gain, and atherosclerosis in mice

Stenger, C, Notet, V, Bonnard, L, Roitel, O, Pratte, D, Magueur, E, Bihain, BE, Yen, FT

J. Biol. Chem. 2008
10224102 Molecular cloning of a lipolysis-stimulated remnant receptor expressed in the liver

Grosset, JM, Bihain, BE, Guerassimenko, O, André, P, Masson, M, Clossais-Besnard, N, Dumas, JB, Bougueleret, L, Yen, FT

J. Biol. Chem. 1999
15265030 Distribution of the lipolysis stimulated receptor in adult and embryonic murine tissues and lethality of LSR-/- embryos at 12.5 to 14.5 days of gestation

Bérard, AM, Darmon, M, Kivlichan, D, Javorschi, S, Mesli, S, Bihain, BE, Yen, FT, Landry, M, Smith, AJ, Priddle, H

Eur. J. Biochem. 2004
Participants
Input
Output
Orthologous Events
LSR trimer binds VLDL (Homo sapiens)
Authored
Jassal, B  (2016-08-04)
Reviewed
D'Eustachio, P  (2016-08-12)
Created
Jassal, B  (2016-08-04)
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