Reactome | GNAS1 [plasma membrane]

GNAS1 [plasma membrane]

Stable Identifier

R-MMU-8873940

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

plasma membrane

Synonyms

Q6R0H7

Locations in the PathwayBrowser

Expand all

Hemostasis (Mus musculus)

- Platelet homeostasis (Mus musculus)
  - Prostacyclin signalling through prostacyclin receptor (Mus musculus)
    - Gs activation by prostacyclin receptor (Mus musculus)
      - Prostacyclin:prostacyclin receptor:G-protein Gs (active) [plasma membrane] (Mus musculus)
        
        Heterotrimeric G-protein Gs (active) [plasma membrane] (Mus musculus)
        
        G alpha (s):GTP [plasma membrane] (Mus musculus)
        
        GNAS [plasma membrane] (Mus musculus)
        
        GNAS1 [plasma membrane] (Mus musculus)
      - Prostacyclin:prostacyclin receptor:Gs (inactive) [plasma membrane] (Mus musculus)
        
        Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Mus musculus)
        
        G alpha (s):GDP [plasma membrane] (Mus musculus)
        
        GNAS [plasma membrane] (Mus musculus)
        
        GNAS1 [plasma membrane] (Mus musculus)

Metabolism (Mus musculus)

- Integration of energy metabolism (Mus musculus)
  - Regulation of insulin secretion (Mus musculus)
    - Glucagon-like Peptide-1 (GLP1) regulates insulin secretion (Mus musculus)
      - GLP1R binds GLP1 (Mus musculus)
        
        GLP1:GLP1R:Heterotrimeric G(s):GDP [plasma membrane] (Mus musculus)
        
        G alpha (s):GDP [plasma membrane] (Mus musculus)
        
        GNAS [plasma membrane] (Mus musculus)
        
        GNAS1 [plasma membrane] (Mus musculus)
        
        GLP1R:Heterotrimeric G(s):GDP [plasma membrane] (Mus musculus)
        
        G alpha (s):GDP [plasma membrane] (Mus musculus)
        
        GNAS [plasma membrane] (Mus musculus)
        
        GNAS1 [plasma membrane] (Mus musculus)
      - GLP1R binds GLP1R agonists (Mus musculus)
        
        GLP1R:GLP1R agonists [plasma membrane] (Mus musculus)
        
        GLP1R:Heterotrimeric G(s):GDP [plasma membrane] (Mus musculus)
        
        G alpha (s):GDP [plasma membrane] (Mus musculus)
        
        GNAS [plasma membrane] (Mus musculus)
        
        GNAS1 [plasma membrane] (Mus musculus)
        
        GLP1R:Heterotrimeric G(s):GDP [plasma membrane] (Mus musculus)
        
        G alpha (s):GDP [plasma membrane] (Mus musculus)
        
        GNAS [plasma membrane] (Mus musculus)
        
        GNAS1 [plasma membrane] (Mus musculus)

Signal Transduction (Mus musculus)

- Signaling by GPCR (Mus musculus)
  - GPCR downstream signalling (Mus musculus)
    - G alpha (s) signalling events (Mus musculus)
      - GPER1 signaling (Mus musculus)
        
        ESTG stimulates GTP exchange on GPER:heterotrimeric G-protein s (Mus musculus)
        
        GPER1:Heterotrimeric G-protein Gs (active):ESTG [plasma membrane] (Mus musculus)
        
        Heterotrimeric G-protein Gs (active) [plasma membrane] (Mus musculus)
        
        G alpha (s):GTP [plasma membrane] (Mus musculus)
        
        GNAS [plasma membrane] (Mus musculus)
        
        GNAS1 [plasma membrane] (Mus musculus)
        
        GPER1:Heterotrimeric G-protein Gs:ESTG [plasma membrane] (Mus musculus)
        
        GPER1:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Mus musculus)
        
        Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Mus musculus)
        
        G alpha (s):GDP [plasma membrane] (Mus musculus)
        
        GNAS [plasma membrane] (Mus musculus)
        
        GNAS1 [plasma membrane] (Mus musculus)
        
        GPER:Heterotrimeric G-protein Gs binds ESTG (Mus musculus)
        
        GPER1:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Mus musculus)
        
        Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Mus musculus)
        
        G alpha (s):GDP [plasma membrane] (Mus musculus)
        
        GNAS [plasma membrane] (Mus musculus)
        
        GNAS1 [plasma membrane] (Mus musculus)
        
        GPER1:Heterotrimeric G-protein Gs:ESTG [plasma membrane] (Mus musculus)
        
        GPER1:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Mus musculus)
        
        Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Mus musculus)
        
        G alpha (s):GDP [plasma membrane] (Mus musculus)
        
        GNAS [plasma membrane] (Mus musculus)
        
        GNAS1 [plasma membrane] (Mus musculus)
      - Liganded Gs-activating GPCR acts as a GEF for Gs (Mus musculus)
        
        Ade-Rib:ADORA2B:Heterotrimeric G-protein Gs:GDP [plasma membrane] (Mus musculus)
        
        Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Mus musculus)
        
        G alpha (s):GDP [plasma membrane] (Mus musculus)
        
        GNAS [plasma membrane] (Mus musculus)
        
        GNAS1 [plasma membrane] (Mus musculus)
        
        GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Mus musculus)
        
        Heterotrimeric G-protein Gs (active) [plasma membrane] (Mus musculus)
        
        G alpha (s):GTP [plasma membrane] (Mus musculus)
        
        GNAS [plasma membrane] (Mus musculus)
        
        GNAS1 [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Mus musculus)
        
        Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Mus musculus)
        
        G alpha (s):GDP [plasma membrane] (Mus musculus)
        
        GNAS [plasma membrane] (Mus musculus)
        
        GNAS1 [plasma membrane] (Mus musculus)
  - GPCR ligand binding (Mus musculus)
    - Class B/2 (Secretin family receptors) (Mus musculus)
      - Glucagon-type ligand receptors (Mus musculus)
        
        GLP1R binds GLP1 (Mus musculus)
        
        GLP1:GLP1R:Heterotrimeric G(s):GDP [plasma membrane] (Mus musculus)
        
        G alpha (s):GDP [plasma membrane] (Mus musculus)
        
        GNAS [plasma membrane] (Mus musculus)
        
        GNAS1 [plasma membrane] (Mus musculus)
        
        GLP1R:Heterotrimeric G(s):GDP [plasma membrane] (Mus musculus)
        
        G alpha (s):GDP [plasma membrane] (Mus musculus)
        
        GNAS [plasma membrane] (Mus musculus)
        
        GNAS1 [plasma membrane] (Mus musculus)

Transport of small molecules (Mus musculus)

- Aquaporin-mediated transport (Mus musculus)
  - Vasopressin regulates renal water homeostasis via Aquaporins (Mus musculus)
    - AVP:AVPR2:heterotrimeric G(s) complex exchanges GDP for GTP (Mus musculus)
      - AVPR2:AVP:G-alpha(s):GDP:G-beta:G-gamma [plasma membrane] (Mus musculus)
        
        G-alpha(s):GDP:G-beta:G-gamma [plasma membrane] (Mus musculus)
        
        G alpha (s):GDP [plasma membrane] (Mus musculus)
        
        GNAS [plasma membrane] (Mus musculus)
        
        GNAS1 [plasma membrane] (Mus musculus)
      - AVPR2:AVP:G-alpha(s):GTP:G-beta:G-gamma [plasma membrane] (Mus musculus)
        
        G-alpha(s):GTP:G-beta:G-gamma [plasma membrane] (Mus musculus)
        
        G alpha (s):GTP [plasma membrane] (Mus musculus)
        
        GNAS [plasma membrane] (Mus musculus)
        
        GNAS1 [plasma membrane] (Mus musculus)

External Reference Information

External Reference

UniProt:Q6R0H7

Reference Genes

BioGPS Gene:14683

ENSEMBL:ENSMUSG00000027523

ENSEMBL:ENSMUSG00000027523.21

Monarch:14683

NCBI Gene:14683

UCSC:Q6R0H7

Reference Transcript

Other Identifiers

10479112

1450186_s_at

14683

4347775

4356006

4439290

4446064

4554963

4590742

4593397

4651044

4656289

4687047

4688531

4694483

4713121

4852666

5043555

5090446

5129717

5153127

5165522

5330401

5380045

5450260

5459223

5477282

5545651

5555101

5563968

5594707

5614172

93271_s_at

A_51_P326769

A_52_P190394

A_55_P2081313

A_66_P115337

C80321_rc_f_at

GE102757

GE35476

GO:0000166

GO:0001501

GO:0001726

GO:0001894

GO:0001934

GO:0001958

GO:0001965

GO:0002376

GO:0003013

GO:0003824

GO:0003924

GO:0003925

GO:0005159

GO:0005515

GO:0005525

GO:0005634

GO:0005737

GO:0005768

GO:0005794

GO:0005829

GO:0005834

GO:0005886

GO:0006091

GO:0006112

GO:0006306

GO:0006325

GO:0006351

GO:0006355

GO:0006357

GO:0007155

GO:0007165

GO:0007186

GO:0007189

GO:0007191

GO:0007606

GO:0008092

GO:0008284

GO:0009410

GO:0009791

GO:0009966

GO:0010765

GO:0010854

GO:0010856

GO:0016020

GO:0016324

GO:0016787

GO:0019001

GO:0019904

GO:0023052

GO:0030142

GO:0030154

GO:0030425

GO:0031410

GO:0031681

GO:0031683

GO:0031698

GO:0031748

GO:0031852

GO:0032024

GO:0032588

GO:0035116

GO:0035255

GO:0035264

GO:0036211

GO:0040032

GO:0042060

GO:0042383

GO:0043014

GO:0043025

GO:0043226

GO:0043588

GO:0043950

GO:0045669

GO:0045672

GO:0045776

GO:0046872

GO:0047391

GO:0048471

GO:0048589

GO:0048701

GO:0048856

GO:0050877

GO:0050886

GO:0050890

GO:0051216

GO:0051430

GO:0055037

GO:0060348

GO:0060789

GO:0070527

GO:0071107

GO:0071377

GO:0071380

GO:0071514

GO:0071870

GO:0071880

GO:0098772

GO:0120162

GO:2000828

ILMN_2632206

ILMN_2761847

ILMN_3056973

Msa.725.0_f_at

m13964_f_at

mMC019580

Participates

as a candidate of

GNAS [plasma membrane] (Mus musculus)

Inferred From

GNAS1 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_001297014.1, NP_034439.2, NP_001070975.1, NP_963911.1

Ensembl

ENSMUSP00000158758, ENSMUSP00000140174, ENSMUST00000080493, ENSMUSG00000027523, ENSMUST00000154658, ENSMUST00000185956, ENSMUST00000087876, ENSMUSP00000085184, ENSMUSP00000085185, ENSMUSP00000079341, ENSMUST00000087877

PRO

Q6R0H7

MGI

95777

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