Reactome | Syt8 [clathrin-coated endocytic vesicle membrane]

Syt8 [clathrin-coated endocytic vesicle membrane]

Stable Identifier

R-MMU-8869119

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

clathrin-coated endocytic vesicle membrane

Synonyms

SYT8, Q9R0N6

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Mus musculus)

- Membrane Trafficking (Mus musculus)
  - Clathrin-mediated endocytosis (Mus musculus)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        SYT8 dimer [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        Syt8 [clathrin-coated endocytic vesicle membrane] (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        SYT8 dimer [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        Syt8 [clathrin-coated endocytic vesicle membrane] (Mus musculus)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        SYT8 dimer [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        Syt8 [clathrin-coated endocytic vesicle membrane] (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        SYT8 dimer [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        Syt8 [clathrin-coated endocytic vesicle membrane] (Mus musculus)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Mus musculus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        SYT8 dimer [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        Syt8 [clathrin-coated endocytic vesicle membrane] (Mus musculus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        SYT8 dimer [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        Syt8 [clathrin-coated endocytic vesicle membrane] (Mus musculus)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        SYT8 dimer [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        Syt8 [clathrin-coated endocytic vesicle membrane] (Mus musculus)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Mus musculus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        SYT8 dimer [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        Syt8 [clathrin-coated endocytic vesicle membrane] (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        SYT8 dimer [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        Syt8 [clathrin-coated endocytic vesicle membrane] (Mus musculus)
    - RAB5 and GAPVD1 bind AP-2 (Mus musculus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        SYT8 dimer [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        Syt8 [clathrin-coated endocytic vesicle membrane] (Mus musculus)

External Reference Information

External Reference

UniProt:Q9R0N6

Gene Names

Syt8

Reference Genes

BioGPS Gene:55925 Syt8

ENSEMBL:ENSMUSG00000031098

Monarch:55925 Syt8

NCBI Gene:55925 Syt8

UCSC:Q9R0N6 Syt8

Reference Transcript

Other Identifiers

10559185

1450800_at

17485200

4464078

4534247

4619978

4698591

4860390

4877670

4974063

4995101

5046495

5082077

5103010

5105773

5220237

5292970

5306567

5332190

5367976

5406087

5488952

5580819

55925

5594945

5596748

5612672

92682_at

A_51_P453657

A_55_P1981681

GE37301

GO:0000149

GO:0001669

GO:0001786

GO:0005509

GO:0005544

GO:0005737

GO:0005886

GO:0007340

GO:0008289

GO:0016020

GO:0016192

GO:0022414

GO:0030276

GO:0030424

GO:0030672

GO:0031045

GO:0031410

GO:0031982

GO:0043226

GO:0048306

GO:0048488

GO:0048791

GO:0070382

ILMN_2593457

Msa.1876.0_at

Msa.1876.0_g_at

mMC003504

Participates

as a component of

SYT8 dimer [clathrin-coated endocytic vesicle membrane] (Mus musculus)

Other forms of this molecule

Syt8 [plasma membrane]

Inferred From

SYT8 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

Cross References

ENSEMBL

ENSMUST00000122393, ENSMUSP00000112689, ENSMUSP00000113545, ENSMUST00000118276

PRO

Q9R0N6

MGI

1859867

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