Reactome | SYT2 [clathrin-coated endocytic vesicle membrane]

SYT2 [clathrin-coated endocytic vesicle membrane]

Stable Identifier

R-MMU-8869116

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

clathrin-coated endocytic vesicle membrane

Synonyms

P46097

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Mus musculus)

- Membrane Trafficking (Mus musculus)
  - Clathrin-mediated endocytosis (Mus musculus)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        SYT2 dimer [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        SYT2 [clathrin-coated endocytic vesicle membrane] (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        SYT2 dimer [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        SYT2 [clathrin-coated endocytic vesicle membrane] (Mus musculus)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        SYT2 dimer [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        SYT2 [clathrin-coated endocytic vesicle membrane] (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        SYT2 dimer [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        SYT2 [clathrin-coated endocytic vesicle membrane] (Mus musculus)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Mus musculus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        SYT2 dimer [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        SYT2 [clathrin-coated endocytic vesicle membrane] (Mus musculus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        SYT2 dimer [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        SYT2 [clathrin-coated endocytic vesicle membrane] (Mus musculus)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        SYT2 dimer [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        SYT2 [clathrin-coated endocytic vesicle membrane] (Mus musculus)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Mus musculus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        SYT2 dimer [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        SYT2 [clathrin-coated endocytic vesicle membrane] (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        SYT2 dimer [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        SYT2 [clathrin-coated endocytic vesicle membrane] (Mus musculus)
    - RAB5 and GAPVD1 bind AP-2 (Mus musculus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        SYT2 dimer [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        SYT2 [clathrin-coated endocytic vesicle membrane] (Mus musculus)

External Reference Information

External Reference

UniProt:P46097

Reference Genes

BioGPS Gene:20980

ENSEMBL:ENSMUSG00000026452

KEGG Gene (Mus musculus):20980

Monarch:20980

NCBI Gene:20980

UCSC:P46097

Reference Transcript

Participates

as a component of

SYT2 dimer [clathrin-coated endocytic vesicle membrane] (Mus musculus)

Other forms of this molecule

SYT2 [plasma membrane]

Inferred From

SYT2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

Cross References

RefSeq

NP_033333.2, XP_006529385.1, XP_006529386.1

PRO

P46097

MGI

99666

PDB

2NP0, 4KBB

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P10844 botB	8	botB HC [synaptic vesicle membrane] (R-CBO-5228953) botB LC [cytosol] (R-CBO-181489) botB LC disulfide bonded [extracellular region] (R-CBO-181565) botB LC disulfide bonded [plasma membrane] (R-CBO-181466) botB HC disulfide bonded [plasma membrane] (R-CBO-181485) botB HC disulfide bonded [synaptic vesicle membrane] (R-CBO-181459) botB LC disulfide bonded [synaptic vesicle membrane] (R-CBO-181465) botB HC disulfide bonded [extracellular region] (R-CBO-181507)	0.683	3

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