Reactome | Scarb2 [clathrin-coated endocytic vesicle membrane]

Scarb2 [clathrin-coated endocytic vesicle membrane]

Stable Identifier

R-MMU-8869106

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

clathrin-coated endocytic vesicle membrane

Synonyms

SCARB2, O35114

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Mus musculus)

- Membrane Trafficking (Mus musculus)
  - Clathrin-mediated endocytosis (Mus musculus)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        Scarb2 [clathrin-coated endocytic vesicle membrane] (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        Scarb2 [clathrin-coated endocytic vesicle membrane] (Mus musculus)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        Scarb2 [clathrin-coated endocytic vesicle membrane] (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        Scarb2 [clathrin-coated endocytic vesicle membrane] (Mus musculus)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Mus musculus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        Scarb2 [clathrin-coated endocytic vesicle membrane] (Mus musculus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        Scarb2 [clathrin-coated endocytic vesicle membrane] (Mus musculus)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        Scarb2 [clathrin-coated endocytic vesicle membrane] (Mus musculus)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Mus musculus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        Scarb2 [clathrin-coated endocytic vesicle membrane] (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        Scarb2 [clathrin-coated endocytic vesicle membrane] (Mus musculus)
    - RAB5 and GAPVD1 bind AP-2 (Mus musculus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        Scarb2 [clathrin-coated endocytic vesicle membrane] (Mus musculus)

External Reference Information

External Reference

UniProt:O35114

Gene Names

Scarb2

Reference Genes

BioGPS Gene:12492 Scarb2

ENSEMBL:ENSMUSG00000029426

KEGG:mmu:12492 Scarb2

Monarch:12492 Scarb2

NCBI Gene:12492 Scarb2

UCSC:O35114 Scarb2

Reference Transcript

RefSeq:NM_007644.4 Scarb2

Other Identifiers

101389_at

10531437

112784_at

12492

1454704_at

1460235_at

17449749

4353968

4371495

4428839

4580343

4585457

4758899

4797079

4888120

4921152

4940986

5062207

5089733

5097484

5125909

5130504

5264077

5418238

5536234

5606235

5608049

AB008553_at

AB008553_g_at

A_51_P180362

A_52_P311245

A_65_P18727

GE1071609

GE1430397

GE34824

GO:0001786

GO:0005044

GO:0005515

GO:0005764

GO:0005765

GO:0005886

GO:0006622

GO:0006886

GO:0006898

GO:0006914

GO:0007605

GO:0008289

GO:0015485

GO:0015917

GO:0016020

GO:0016192

GO:0019899

GO:0030666

GO:0031210

GO:0038024

GO:0042803

GO:0043202

GO:0043470

GO:0050877

GO:0051087

GO:0099638

ILMN_1246340

ILMN_2704233

ILMN_2907331

mMC007578

mMC014325

Participates

as a member of

AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)

Other forms of this molecule

Scarb2 [plasma membrane]

Inferred From

SCARB2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

Cross References

RefSeq

NP_031670.1

ENSEMBL

ENSMUSG00000029426, ENSMUST00000031377, ENSMUSP00000031377

PRO

O35114

MGI

1196458

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