Reactome | Chrm2 [clathrin-coated endocytic vesicle membrane]

Chrm2 [clathrin-coated endocytic vesicle membrane]

Stable Identifier

R-MMU-8869085

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

clathrin-coated endocytic vesicle membrane

Synonyms

CHRM2, Q9ERZ4

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Mus musculus)

- Membrane Trafficking (Mus musculus)
  - Clathrin-mediated endocytosis (Mus musculus)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        Chrm2 [clathrin-coated endocytic vesicle membrane] (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        Chrm2 [clathrin-coated endocytic vesicle membrane] (Mus musculus)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        Chrm2 [clathrin-coated endocytic vesicle membrane] (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        Chrm2 [clathrin-coated endocytic vesicle membrane] (Mus musculus)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Mus musculus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        Chrm2 [clathrin-coated endocytic vesicle membrane] (Mus musculus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        Chrm2 [clathrin-coated endocytic vesicle membrane] (Mus musculus)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        Chrm2 [clathrin-coated endocytic vesicle membrane] (Mus musculus)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Mus musculus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        Chrm2 [clathrin-coated endocytic vesicle membrane] (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        Chrm2 [clathrin-coated endocytic vesicle membrane] (Mus musculus)
    - RAB5 and GAPVD1 bind AP-2 (Mus musculus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        Chrm2 [clathrin-coated endocytic vesicle membrane] (Mus musculus)

External Reference Information

External Reference

UniProt:Q9ERZ4

Gene Names

Chrm2

Reference Genes

BioGPS Gene:243764 Chrm2

ENSEMBL:ENSMUSG00000045613

KEGG:mmu:243764 Chrm2

Monarch:243764 Chrm2

NCBI Gene:243764 Chrm2

UCSC:Q9ERZ4 Chrm2

Reference Transcript

Other Identifiers

10537298

138097_f_at

17457310

243764

4349702

4394534

4425956

4462455

4500575

4848663

5014349

5027540

5592847

A_51_P292341

A_55_P2055284

GE1389348

GE1549345

GO:0004930

GO:0004993

GO:0005886

GO:0006940

GO:0007186

GO:0007187

GO:0007197

GO:0007213

GO:0007268

GO:0008016

GO:0009615

GO:0016020

GO:0016907

GO:0023052

GO:0030425

GO:0032279

GO:0032280

GO:0042734

GO:0043025

GO:0043679

GO:0045202

GO:0045211

GO:0060089

GO:0098664

GO:0098978

GO:0098981

GO:0099171

GO:1990763

ILMN_1212801

ILMN_2766727

ILMN_2971508

mMC014796

mMC019695

Participates

as a member of

ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Mus musculus)

Other forms of this molecule

Chrm2 [plasma membrane]

Inferred From

CHRM2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

Cross References

RefSeq

NP_987076.2, XP_006506199.1

ZINC - Metabolites

ACM2_MOUSE

ENSEMBL

ENSMUST00000172278, ENSMUSG00000045613, ENSMUSP00000130874

ZINC - FDA approved

ACM2_MOUSE

ZINC - Substances

ACM2_MOUSE

ZINC - Biogenic

ACM2_MOUSE

ZINC target

Q9ERZ4

PRO

Q9ERZ4

GlyGen

Q9ERZ4

MGI

88397

ZINC - Predictions - Purchasable

ACM2_MOUSE

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