Brwd1 gene expression is inhibited by p-Stat5 dimers

Stable Identifier
R-MMU-8865699
Type
Reaction [omitted]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Brwd1 gene expression is inhibited by p-Stat5 dimers

Binding of the activated Stat5 dimer to the Brwd1 gene promoter in mouse pro-B cells results in inhibition of the Brwd1 gene transcription, coincidentally with the appearance of H3K27me3 repressive marks at the Brwd1 promoter region (Mandal et al. 2015).

Literature References
PubMed ID Title Journal Year
26301565 Histone reader BRWD1 targets and restricts recombination to the Igk locus

Mandal, M, Hamel, KM, Maienschein-Cline, M, Tanaka, A, Teng, G, Tuteja, JH, Bunker, JJ, Bahroos, N, Eppig, JJ, Schatz, DG, Clark, MR

Nat. Immunol. 2015
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