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phospho-PolyUb,p-Y700,Y731,Y774-CBL [cytosol]
Stable Identifier
R-MMU-8848826
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
P22682
Locations in the PathwayBrowser for interactor UniProt:P13379 CD5
Expand all
Signal Transduction (Mus musculus)
Signaling by Non-Receptor Tyrosine Kinases (Mus musculus)
Signaling by PTK6 (Mus musculus)
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 (Mus musculus)
CBL autoubiquitinates (Mus musculus)
phospho-PolyUb,p-Y700,Y731,Y774-CBL [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:P22682 Cbl
Gene Names
Cbl
Chain
chain:1-913
Reference Genes
BioGPS Gene:12402 Cbl
ENSEMBL:ENSMUSG00000034342.10 Cbl
KEGG Gene (Mus musculus):12402 Cbl
Monarch:12402 Cbl
NCBI Gene:12402 Cbl
UCSC:P22682 Cbl
Reference Transcript
RefSeq:NM_007619.2 Cbl
Other Identifiers
100291_at
10592734
116969_at
12402
1434829_at
1450457_at
1455886_at
17526130
4361862
4403536
4415417
4420368
4508041
4593724
4598445
4633693
4740321
4741176
4809000
4814464
4883602
4980486
4993737
5023099
5027471
5035380
5036985
5038915
5080629
5095709
5143702
5306058
5336414
5377256
5386113
5386244
5398407
5408432
5421993
5430525
5515408
5526809
5557574
5575005
99092_at
A_52_P153939
A_52_P819011
A_55_P2070174
A_55_P2800298
GE1548980
GE34815
GO:0000209
GO:0001784
GO:0002376
GO:0003824
GO:0004842
GO:0005509
GO:0005515
GO:0005737
GO:0005794
GO:0005829
GO:0005886
GO:0005925
GO:0005929
GO:0006468
GO:0006511
GO:0006513
GO:0006974
GO:0007165
GO:0007166
GO:0008152
GO:0008584
GO:0010332
GO:0012501
GO:0014823
GO:0016020
GO:0016192
GO:0016567
GO:0016600
GO:0016740
GO:0017124
GO:0019901
GO:0022414
GO:0023051
GO:0023052
GO:0030163
GO:0030424
GO:0030426
GO:0030971
GO:0032487
GO:0033574
GO:0036120
GO:0036211
GO:0036312
GO:0042059
GO:0042594
GO:0042995
GO:0043066
GO:0043226
GO:0043303
GO:0045121
GO:0045453
GO:0045471
GO:0046872
GO:0046875
GO:0048260
GO:0048471
GO:0048856
GO:0051865
GO:0051897
GO:0061630
GO:0070086
GO:0071456
GO:0140096
GO:1990090
GO:1990782
GO:2000583
ILMN_2649011
Msa.2194.0_at
mMC017603
Participates
as an output of
CBL autoubiquitinates (Mus musculus)
Other forms of this molecule
Cbl [cytosol]
p-Y-Cbl [cytosol]
phospho-p-Y-CBL [cytosol]
phospho-p-Y371-CBL [cytosol]
phospho-p-Y371-CBL [plasma membrane]
phospho-p-Y700,Y731,Y774-CBL [cytosol]
CBL [cytosol]
Inferred From
PolyUb,p-Y700,Y731,Y774-CBL [cytosol]
(Homo sapiens)
Modified Residues
Name
O4'-phospho-L-tyrosine at 731 (in Homo sapiens)
Coordinate
731
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 700 (in Homo sapiens)
Coordinate
700
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 774 (in Homo sapiens)
Coordinate
774
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
ubiquitinylated lysine (polyubiquitin chain [cytosol]) at unknown position
Modification
polyubiquitin chain [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
NP_031645.2
IntEnz
2.3.2.27
Ensembl
ENSMUSP00000146244
,
ENSMUST00000206720
,
ENSMUSG00000034342
PRO
P22682
MGI
88279
PDB
2D9S
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q60631 Grb2
3
Grb2 [cytosol]
(R-MMU-74686)
Grb2 [plasma membrane]
(R-MMU-202993)
Grb2 [cytosol]
(R-MMU-443287)
0.643
7
UniProt:P39688 Fyn
6
Fyn [cytosol]
(R-MMU-420333)
phospho-MyrG-p-Y420-FYN-1 [plasma membrane]
(R-MMU-9032530)
pFyn (420) [cytosol]
(R-MMU-420335)
pFyn(Y531) [cytosol]
(R-MMU-420350)
phospho-p-S21,Y420-FYN [cytosol]
(R-MMU-5218745)
MyrG,p-Y420-Fyn [plasma membrane]
(R-MMU-9037733)
0.564
5
UniProt:Q9JLQ0 Cd2ap
1
CD2AP_MOUSE [cytosol]
(R-MMU-451711)
0.547
5
UniProt:Q6Q899 Rigi
4
PolyUb-DDX58 [cytosol]
(R-MMU-6782770)
Rig-I [cytosol]
(R-MMU-936468)
K63polyUb-DDX58 [cytosol]
(R-MMU-918191)
DDX58 [cytosol]
(R-MMU-168917)
0.537
3
UniProt:Q3U1F9
2
Pag1 [plasma membrane]
(R-MMU-180500)
phospho-Pag1 [plasma membrane]
(R-MMU-180494)
0.499
2
UniProt:P13379 CD5
0.499
5
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.499
2
UniProt:Q01279
6
phospho-p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-MMU-8869138)
phospho-p-4Y-EGFR [plasma membrane]
(R-MMU-180287)
phospho-p-Y1016,Y1069,Y1092,Y1110,Y1197-EGFR [plasma membrane]
(R-MMU-8864019)
EGFR [plasma membrane]
(R-MMU-179837)
phospho-p-Y1086,Y1101-EGFR [plasma membrane]
(R-MMU-179868)
phospho-p-6Y-EGFR [plasma membrane]
(R-MMU-179803)
0.499
2
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