Gdpd3 hydrolyzes LysoPtdCho

Stable Identifier
R-MMU-8847427
Type
Reaction [transition]
Species
Mus musculus
Compartment
endoplasmic reticulum membrane, cytosol
ReviewStatus
5/5
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Gdpd3 hydrolyzes LysoPtdCho
The mouse enzyme Gdpd3 (Glycerophosphodiester phosphodiesterase domain-containing protein 3, also known as Gde7 - Glycerophosphodiester phosphodiesterase 7) associated with the endoplasmic reticulum membrane catalyzes the hydrolysis of LysoPtcCho (lysophosphatidylcholine) to GPCho (glycerophosphocholine) and LCFA (long chain fatty acid) (Oshima et al. 2015).
Literature References
PubMed ID Title Journal Year
25528375 New members of the mammalian glycerophosphodiester phosphodiesterase family: GDE4 and GDE7 produce lysophosphatidic acid by lysophospholipase D activity

Honda, A, Araki, M, Corda, D, Mariggiò, S, Yamashita, Y, Kato, N, Nagano, T, Yanaka, Noriyuki, Ohshima, N, Izumi, T, Isaji, C, Kudo, T

J. Biol. Chem. 2015
Participants
Input
Output
Catalyst Activity

lysophospholipase activity of Gdpd3 [endoplasmic reticulum membrane]

Physical Entity
Gdpd3 [endoplasmic reticulum membrane] (Mus musculus)
Activity
lysophospholipase activity (GO:0004622)
Orthologous Events
GDPD3 hydrolyzes LysoPtdCho (Homo sapiens)
Authored
D'Eustachio, P  (2015-11-28)
Reviewed
Jassal, B  (2015-11-30)
Created
D'Eustachio, P  (2015-11-30)
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