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Nbn [nucleoplasm]
Stable Identifier
R-MMU-75163
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
nucleoplasm
Synonyms
NBN, Q9R207
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Mus musculus)
Cellular responses to stress (Mus musculus)
Cellular Senescence (Mus musculus)
DNA Damage/Telomere Stress Induced Senescence (Mus musculus)
KAT5 acetylates ATM at DNA DSBs (Mus musculus)
DNA DSBs:MRN:ATM dimer:KAT5 [nucleoplasm] (Mus musculus)
DNA DSBs:MRN [nucleoplasm] (Mus musculus)
MRN [nucleoplasm] (Mus musculus)
Nbn [nucleoplasm] (Mus musculus)
DNA DSBs:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Mus musculus)
DNA DSBs:MRN [nucleoplasm] (Mus musculus)
MRN [nucleoplasm] (Mus musculus)
Nbn [nucleoplasm] (Mus musculus)
KAT5 acetylates ATM at shortened telomeres (Mus musculus)
Shortened telomere:MRN:ATM dimer:KAT5 [nucleoplasm] (Mus musculus)
Shortened telomere:MRN [nucleoplasm] (Mus musculus)
MRN [nucleoplasm] (Mus musculus)
Nbn [nucleoplasm] (Mus musculus)
Shortened telomere:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Mus musculus)
Shortened telomere:MRN [nucleoplasm] (Mus musculus)
MRN [nucleoplasm] (Mus musculus)
Nbn [nucleoplasm] (Mus musculus)
MRN activates ATM (Mus musculus)
DNA DSBs:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Mus musculus)
DNA DSBs:MRN [nucleoplasm] (Mus musculus)
MRN [nucleoplasm] (Mus musculus)
Nbn [nucleoplasm] (Mus musculus)
DNA DSBs:MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Mus musculus)
DNA DSBs:MRN [nucleoplasm] (Mus musculus)
MRN [nucleoplasm] (Mus musculus)
Nbn [nucleoplasm] (Mus musculus)
MRN bound to shortened telomeres activates ATM (Mus musculus)
Shortened telomere:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Mus musculus)
Shortened telomere:MRN [nucleoplasm] (Mus musculus)
MRN [nucleoplasm] (Mus musculus)
Nbn [nucleoplasm] (Mus musculus)
Shortened telomere:MRN:KAT5:p-S1981,Ac-K3016-ATM [nucleoplasm] (Mus musculus)
Shortened telomere:MRN [nucleoplasm] (Mus musculus)
MRN [nucleoplasm] (Mus musculus)
Nbn [nucleoplasm] (Mus musculus)
MRN complex binds DNA double strand breaks (Mus musculus)
DNA DSBs:MRN [nucleoplasm] (Mus musculus)
MRN [nucleoplasm] (Mus musculus)
Nbn [nucleoplasm] (Mus musculus)
MRN [nucleoplasm] (Mus musculus)
Nbn [nucleoplasm] (Mus musculus)
MRN complex binds shortened telomeres (Mus musculus)
MRN [nucleoplasm] (Mus musculus)
Nbn [nucleoplasm] (Mus musculus)
Shortened telomere:MRN [nucleoplasm] (Mus musculus)
MRN [nucleoplasm] (Mus musculus)
Nbn [nucleoplasm] (Mus musculus)
MRN complex bound to DNA ends recruits ATM (Mus musculus)
DNA DSBs:MRN [nucleoplasm] (Mus musculus)
MRN [nucleoplasm] (Mus musculus)
Nbn [nucleoplasm] (Mus musculus)
DNA DSBs:MRN:ATM dimer:KAT5 [nucleoplasm] (Mus musculus)
DNA DSBs:MRN [nucleoplasm] (Mus musculus)
MRN [nucleoplasm] (Mus musculus)
Nbn [nucleoplasm] (Mus musculus)
MRN complex bound to shortened telomeres recruits ATM (Mus musculus)
Shortened telomere:MRN [nucleoplasm] (Mus musculus)
MRN [nucleoplasm] (Mus musculus)
Nbn [nucleoplasm] (Mus musculus)
Shortened telomere:MRN:ATM dimer:KAT5 [nucleoplasm] (Mus musculus)
Shortened telomere:MRN [nucleoplasm] (Mus musculus)
MRN [nucleoplasm] (Mus musculus)
Nbn [nucleoplasm] (Mus musculus)
DNA Repair (Mus musculus)
DNA Double-Strand Break Repair (Mus musculus)
DNA Double Strand Break Response (Mus musculus)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Mus musculus)
ATM phosphorylates NBN (Mus musculus)
DNA DSBs:MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Mus musculus)
DNA DSBs:MRN [nucleoplasm] (Mus musculus)
MRN [nucleoplasm] (Mus musculus)
Nbn [nucleoplasm] (Mus musculus)
Sensing of DNA Double Strand Breaks (Mus musculus)
Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction (Mus musculus)
MRN [nucleoplasm] (Mus musculus)
Nbn [nucleoplasm] (Mus musculus)
Nbn [nucleoplasm] (Mus musculus)
KAT5 acetylates ATM at DNA DSBs (Mus musculus)
DNA DSBs:MRN:ATM dimer:KAT5 [nucleoplasm] (Mus musculus)
DNA DSBs:MRN [nucleoplasm] (Mus musculus)
MRN [nucleoplasm] (Mus musculus)
Nbn [nucleoplasm] (Mus musculus)
DNA DSBs:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Mus musculus)
DNA DSBs:MRN [nucleoplasm] (Mus musculus)
MRN [nucleoplasm] (Mus musculus)
Nbn [nucleoplasm] (Mus musculus)
KPNA2 translocates NBN to the nucleus (Mus musculus)
Nbn [nucleoplasm] (Mus musculus)
MRN activates ATM (Mus musculus)
DNA DSBs:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Mus musculus)
DNA DSBs:MRN [nucleoplasm] (Mus musculus)
MRN [nucleoplasm] (Mus musculus)
Nbn [nucleoplasm] (Mus musculus)
DNA DSBs:MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Mus musculus)
DNA DSBs:MRN [nucleoplasm] (Mus musculus)
MRN [nucleoplasm] (Mus musculus)
Nbn [nucleoplasm] (Mus musculus)
MRN complex binds DNA double strand breaks (Mus musculus)
DNA DSBs:MRN [nucleoplasm] (Mus musculus)
MRN [nucleoplasm] (Mus musculus)
Nbn [nucleoplasm] (Mus musculus)
MRN [nucleoplasm] (Mus musculus)
Nbn [nucleoplasm] (Mus musculus)
MRN complex bound to DNA ends recruits ATM (Mus musculus)
DNA DSBs:MRN [nucleoplasm] (Mus musculus)
MRN [nucleoplasm] (Mus musculus)
Nbn [nucleoplasm] (Mus musculus)
DNA DSBs:MRN:ATM dimer:KAT5 [nucleoplasm] (Mus musculus)
DNA DSBs:MRN [nucleoplasm] (Mus musculus)
MRN [nucleoplasm] (Mus musculus)
Nbn [nucleoplasm] (Mus musculus)
Homology Directed Repair (Mus musculus)
HDR through MMEJ (alt-NHEJ) (Mus musculus)
FEN1 cleaves displaced ssDNA flaps during MMEJ (Mus musculus)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Mus musculus)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Mus musculus)
MRN [nucleoplasm] (Mus musculus)
Nbn [nucleoplasm] (Mus musculus)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:FEN1 [nucleoplasm] (Mus musculus)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8 [nucleoplasm] (Mus musculus)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN [nucleoplasm] (Mus musculus)
MRN [nucleoplasm] (Mus musculus)
Nbn [nucleoplasm] (Mus musculus)
LIG3 ligates remaining SSBs in MMEJ (Mus musculus)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:LIG3:XRCC1 [nucleoplasm] (Mus musculus)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Mus musculus)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Mus musculus)
MRN [nucleoplasm] (Mus musculus)
Nbn [nucleoplasm] (Mus musculus)
MRN [nucleoplasm] (Mus musculus)
Nbn [nucleoplasm] (Mus musculus)
MRN and RBBP8 resect DNA DSBs in MMEJ (Mus musculus)
DNA DSB:MRN:RBBP8 [nucleoplasm] (Mus musculus)
DNA DSBs:MRN [nucleoplasm] (Mus musculus)
MRN [nucleoplasm] (Mus musculus)
Nbn [nucleoplasm] (Mus musculus)
Microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Mus musculus)
Microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Mus musculus)
MRN [nucleoplasm] (Mus musculus)
Nbn [nucleoplasm] (Mus musculus)
MRN complex binds RBBP8 (Mus musculus)
DNA DSB:MRN:RBBP8 [nucleoplasm] (Mus musculus)
DNA DSBs:MRN [nucleoplasm] (Mus musculus)
MRN [nucleoplasm] (Mus musculus)
Nbn [nucleoplasm] (Mus musculus)
DNA DSBs:MRN [nucleoplasm] (Mus musculus)
MRN [nucleoplasm] (Mus musculus)
Nbn [nucleoplasm] (Mus musculus)
MRN recruits LIG3:XRCC1 to MMEJ sites (Mus musculus)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Mus musculus)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Mus musculus)
MRN [nucleoplasm] (Mus musculus)
Nbn [nucleoplasm] (Mus musculus)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:LIG3:XRCC1 [nucleoplasm] (Mus musculus)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Mus musculus)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Mus musculus)
MRN [nucleoplasm] (Mus musculus)
Nbn [nucleoplasm] (Mus musculus)
PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site (Mus musculus)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] (Mus musculus)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Mus musculus)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Mus musculus)
MRN [nucleoplasm] (Mus musculus)
Nbn [nucleoplasm] (Mus musculus)
Microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Mus musculus)
Microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Mus musculus)
MRN [nucleoplasm] (Mus musculus)
Nbn [nucleoplasm] (Mus musculus)
PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Mus musculus)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:FEN1 [nucleoplasm] (Mus musculus)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8 [nucleoplasm] (Mus musculus)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN [nucleoplasm] (Mus musculus)
MRN [nucleoplasm] (Mus musculus)
Nbn [nucleoplasm] (Mus musculus)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] (Mus musculus)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8 [nucleoplasm] (Mus musculus)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN [nucleoplasm] (Mus musculus)
MRN [nucleoplasm] (Mus musculus)
Nbn [nucleoplasm] (Mus musculus)
POLQ extends annealed 3'-ssDNA overhangs in MMEJ (Mus musculus)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] (Mus musculus)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Mus musculus)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Mus musculus)
MRN [nucleoplasm] (Mus musculus)
Nbn [nucleoplasm] (Mus musculus)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] (Mus musculus)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8 [nucleoplasm] (Mus musculus)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN [nucleoplasm] (Mus musculus)
MRN [nucleoplasm] (Mus musculus)
Nbn [nucleoplasm] (Mus musculus)
External Reference Information
External Reference
UniProt:Q9R207
Gene Names
Nbn
Reference Genes
BioGPS Gene:27354 Nbn
ENSEMBL:ENSMUSG00000028224
ENSEMBL:ENSMUSG00000028224.15 Nbn
KEGG Gene (Mus musculus):27354 Nbn
Monarch:27354 Nbn
NCBI Gene:27354 Nbn
UCSC:Q9R207 Nbn
Reference Transcript
RefSeq:NM_013752.3 Nbn
Other Identifiers
103805_at
10503431
1448746_at
17411981
27354
4376700
4425521
4534183
4793673
4845861
4923553
4936367
4977323
4985548
5212438
5290562
5328089
5395799
5420549
5450813
5503023
5562761
5566382
A_51_P309328
A_52_P298548
GE36701
GO:0000077
GO:0000278
GO:0000723
GO:0000724
GO:0000729
GO:0000781
GO:0001701
GO:0001832
GO:0002376
GO:0003677
GO:0003684
GO:0005515
GO:0005634
GO:0005654
GO:0005657
GO:0005694
GO:0005730
GO:0005794
GO:0006260
GO:0006281
GO:0006302
GO:0006310
GO:0006974
GO:0007049
GO:0007093
GO:0007095
GO:0007405
GO:0008284
GO:0012501
GO:0016605
GO:0022414
GO:0023052
GO:0030154
GO:0030870
GO:0031860
GO:0031954
GO:0032200
GO:0032206
GO:0032508
GO:0035825
GO:0035861
GO:0036211
GO:0042405
GO:0043226
GO:0044818
GO:0045190
GO:0045665
GO:0046597
GO:0048145
GO:0048856
GO:0050877
GO:0050885
GO:0051321
GO:0070533
GO:0090656
GO:0090737
GO:0097193
GO:0098687
GO:0110025
GO:0140297
GO:1904354
ILMN_1240392
ILMN_2656006
ILMN_2770333
ILMN_2880745
mMC015642
Participates
as an output of
KPNA2 translocates NBN to the nucleus (Mus musculus)
as an input of
Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction (Mus musculus)
as a component of
MRN [nucleoplasm] (Mus musculus)
Other forms of this molecule
Nbn [cytosol]
phospho-Nbn [nucleoplasm]
Inferred From
NBN [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
NP_038780.3
Ensembl
ENSMUSP00000029879
,
ENSMUSG00000028224
,
ENSMUST00000029879
PRO
Q9R207
MGI
1351625
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q61216
2
Mre11 [cytosol]
(R-MMU-3204309)
Mre11 [nucleoplasm]
(R-MMU-59544)
0.564
2
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