Card9 binds Rip2 (and Nod2)

Stable Identifier
R-MMU-741383
Type
Reaction [binding]
Species
Mus musculus
Compartment
ReviewStatus
5/5
General
SVG |   | PPTX  | SBGN
Card9 binds Rip2 (and Nod2)
CARD9 binds RIP2 and NOD2. In addition overexpression of CARD9 strongly activates the kinases p38 and Jnk while CARD9-deficient mouse macrophages have defects in activation of p38 and Jnk but not NF-kappaB signaling, suggesting that CARD9 is involved in an NF-kappaB-independent signaling pathway (Hsu et al. 2007), but the mechanism is unclear. CARD9 is the key transducer of signals from dectin-1, the major mammalian pattern recognition receptor for the fungal component zymosan (Gross et al. 2006).
Literature References
PubMed ID Title Journal Year
17187069 The adaptor protein CARD9 is required for innate immune responses to intracellular pathogens

Qin, XF, Duramad, O, Lin, X, Wang, D, Li, H, You, Y, Dong, C, Hsu, YM, Zhang, Y

Nat Immunol 2007
Participants
Orthologous Events
Authored
Created
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