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Eif2s2 [cytosol]
Stable Identifier
R-MMU-72512
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
EIF2S2, Q99L45
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Mus musculus)
Cellular responses to stress (Mus musculus)
Cellular response to mitochondrial stress (Mus musculus)
DELE1(143-515):EIF2AK1 enhances phosphorylation of EIF2S1 (EIF2alpha) (Mus musculus)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Mus musculus)
Eif2s2 [cytosol] (Mus musculus)
p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol] (Mus musculus)
Eif2s2 [cytosol] (Mus musculus)
Unfolded Protein Response (UPR) (Mus musculus)
PERK regulates gene expression (Mus musculus)
EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK (Mus musculus)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Mus musculus)
Eif2s2 [cytosol] (Mus musculus)
p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol] (Mus musculus)
Eif2s2 [cytosol] (Mus musculus)
Metabolism of proteins (Mus musculus)
Translation (Mus musculus)
Eukaryotic Translation Initiation (Mus musculus)
Cap-dependent Translation Initiation (Mus musculus)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (Mus musculus)
Translation initiation complex formation (Mus musculus)
Formation of translation initiation complexes containing mRNA that does not circularize (Mus musculus)
43S complex [cytosol] (Mus musculus)
ternary complex [cytosol] (Mus musculus)
eIF2:GTP [cytosol] (Mus musculus)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Mus musculus)
Eif2s2 [cytosol] (Mus musculus)
48S complex [cytosol] (Mus musculus)
43S complex [cytosol] (Mus musculus)
ternary complex [cytosol] (Mus musculus)
eIF2:GTP [cytosol] (Mus musculus)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Mus musculus)
Eif2s2 [cytosol] (Mus musculus)
Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation (Mus musculus)
43S complex [cytosol] (Mus musculus)
ternary complex [cytosol] (Mus musculus)
eIF2:GTP [cytosol] (Mus musculus)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Mus musculus)
Eif2s2 [cytosol] (Mus musculus)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Mus musculus)
43S complex [cytosol] (Mus musculus)
ternary complex [cytosol] (Mus musculus)
eIF2:GTP [cytosol] (Mus musculus)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Mus musculus)
Eif2s2 [cytosol] (Mus musculus)
Formation of the ternary complex, and subsequently, the 43S complex (Mus musculus)
De novo formation of eIF2:GTP (Mus musculus)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Mus musculus)
Eif2s2 [cytosol] (Mus musculus)
eIF2:GTP [cytosol] (Mus musculus)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Mus musculus)
Eif2s2 [cytosol] (Mus musculus)
Formation of the 43S pre-initiation complex (Mus musculus)
43S complex [cytosol] (Mus musculus)
ternary complex [cytosol] (Mus musculus)
eIF2:GTP [cytosol] (Mus musculus)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Mus musculus)
Eif2s2 [cytosol] (Mus musculus)
ternary complex [cytosol] (Mus musculus)
eIF2:GTP [cytosol] (Mus musculus)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Mus musculus)
Eif2s2 [cytosol] (Mus musculus)
Met-tRNAi binds to eIF2:GTP to form the ternary complex (Mus musculus)
eIF2:GTP [cytosol] (Mus musculus)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Mus musculus)
Eif2s2 [cytosol] (Mus musculus)
ternary complex [cytosol] (Mus musculus)
eIF2:GTP [cytosol] (Mus musculus)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Mus musculus)
Eif2s2 [cytosol] (Mus musculus)
GTP hydrolysis and joining of the 60S ribosomal subunit (Mus musculus)
eIF2:GTP is hydrolyzed, eIFs are released (Mus musculus)
48S complex [cytosol] (Mus musculus)
43S complex [cytosol] (Mus musculus)
ternary complex [cytosol] (Mus musculus)
eIF2:GTP [cytosol] (Mus musculus)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Mus musculus)
Eif2s2 [cytosol] (Mus musculus)
eIF2:GDP [cytosol] (Mus musculus)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Mus musculus)
Eif2s2 [cytosol] (Mus musculus)
Recycling of eIF2:GDP (Mus musculus)
Formation of eIF2:GDP:eIF2B intermediate (Mus musculus)
eIF2:GDP [cytosol] (Mus musculus)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Mus musculus)
Eif2s2 [cytosol] (Mus musculus)
eIF2:GDP: eIF2B [cytosol] (Mus musculus)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Mus musculus)
Eif2s2 [cytosol] (Mus musculus)
eIF2 activation (Mus musculus)
eIF2:GDP: eIF2B [cytosol] (Mus musculus)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Mus musculus)
Eif2s2 [cytosol] (Mus musculus)
eIF2:GTP [cytosol] (Mus musculus)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Mus musculus)
Eif2s2 [cytosol] (Mus musculus)
Ribosomal scanning and start codon recognition (Mus musculus)
Ribosomal scanning (Mus musculus)
48S complex [cytosol] (Mus musculus)
43S complex [cytosol] (Mus musculus)
ternary complex [cytosol] (Mus musculus)
eIF2:GTP [cytosol] (Mus musculus)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Mus musculus)
Eif2s2 [cytosol] (Mus musculus)
Start codon recognition (Mus musculus)
48S complex [cytosol] (Mus musculus)
43S complex [cytosol] (Mus musculus)
ternary complex [cytosol] (Mus musculus)
eIF2:GTP [cytosol] (Mus musculus)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Mus musculus)
Eif2s2 [cytosol] (Mus musculus)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Mus musculus)
Eif2s2 [cytosol] (Mus musculus)
L13a-mediated translational silencing of Ceruloplasmin expression (Mus musculus)
Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Mus musculus)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Mus musculus)
43S complex [cytosol] (Mus musculus)
ternary complex [cytosol] (Mus musculus)
eIF2:GTP [cytosol] (Mus musculus)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Mus musculus)
Eif2s2 [cytosol] (Mus musculus)
phospho-L13a associated wth the 3' UTR GAIT element of ceruloplasmin mRNA within the translation initiation complex [cytosol] (Mus musculus)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Mus musculus)
43S complex [cytosol] (Mus musculus)
ternary complex [cytosol] (Mus musculus)
eIF2:GTP [cytosol] (Mus musculus)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Mus musculus)
Eif2s2 [cytosol] (Mus musculus)
Transport of small molecules (Mus musculus)
ABC-family proteins mediated transport (Mus musculus)
ABCF1 binds EIF2 (Mus musculus)
ABCF1:EIF2S1:EIF2S2:EIF2S3 [cytosol] (Mus musculus)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Mus musculus)
Eif2s2 [cytosol] (Mus musculus)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Mus musculus)
Eif2s2 [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:Q99L45 Eif2s2
Gene Names
Eif2s2
Chain
initiator methionine:, chain:2-331
Reference Genes
BioGPS Gene:67204 Eif2s2
ENSEMBL:ENSMUSG00000074656.14 Eif2s2
KEGG Gene (Mus musculus):67204 Eif2s2
Monarch:67204 Eif2s2
NCBI Gene:67204 Eif2s2
UCSC:Q99L45 Eif2s2
Reference Transcript
RefSeq:NM_026030.2 Eif2s2
Other Identifiers
10488806
10578683
1417712_at
1417713_at
1448819_at
1448820_a_at
1456617_a_at
160365_at
17393192
4326287
4420271
4465786
4505625
4549377
4557042
4690518
4692137
4864271
4908325
4963560
5130482
5181870
5302906
5369760
5505423
5533321
67204
A_52_P107354
A_55_P2089655
GE41738
GO:0001701
GO:0001731
GO:0001732
GO:0002176
GO:0002181
GO:0002183
GO:0003723
GO:0003729
GO:0003743
GO:0005515
GO:0005737
GO:0005829
GO:0005850
GO:0006412
GO:0006413
GO:0008584
GO:0022414
GO:0031369
GO:0045182
GO:0045202
GO:0046872
GO:0048856
GO:0065003
ILMN_1256795
ILMN_2774435
Msa.4559.0_s_at
aa544671_g_at
mMC001876
Participates
as a component of
p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol] (Mus musculus)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Mus musculus)
Other forms of this molecule
Eif2s2 [cytosol]
Inferred From
EIF2S2 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_080306.1
Ensembl
ENSMUSG00000074656
,
ENSMUSP00000096777
,
ENSMUST00000099173
PRO
Q99L45
MGI
1914454
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