Reactome | Rpl17 [cytosol]

Rpl17 [cytosol]

Stable Identifier

R-MMU-72418

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

RPL17, Q9CPR4

Locations in the PathwayBrowser

Expand all

Metabolism of RNA (Mus musculus)

- Nonsense-Mediated Decay (NMD) (Mus musculus)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Mus musculus)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Mus musculus)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        Rpl17 [cytosol] (Mus musculus)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        Rpl17 [cytosol] (Mus musculus)
    - SMG6 hydrolyzes mRNA with premature termination codon (Mus musculus)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        Rpl17 [cytosol] (Mus musculus)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Mus musculus)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        Rpl17 [cytosol] (Mus musculus)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        Rpl17 [cytosol] (Mus musculus)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Mus musculus)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        Rpl17 [cytosol] (Mus musculus)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        Rpl17 [cytosol] (Mus musculus)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Mus musculus)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Mus musculus)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        Rpl17 [cytosol] (Mus musculus)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        Rpl17 [cytosol] (Mus musculus)
- rRNA processing (Mus musculus)
  - rRNA processing in the nucleus and cytosol (Mus musculus)
    - Major pathway of rRNA processing in the nucleolus and cytosol (Mus musculus)
      - 12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        Rpl17 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q9CPR4 Rpl17

Gene Names

Rpl17

Chain

chain:1-184

Reference Genes

BioGPS Gene:319195 Rpl17

ENSEMBL:ENSMUSG00000062328.9 Rpl17

KEGG Gene (Mus musculus):319195 Rpl17

Monarch:319195 Rpl17

NCBI Gene:319195 Rpl17

Reference Transcript

Other Identifiers

10346808

10356778

10380670

10396059

10405626

10416835

10429389

10455210

10456709

10513737

10528478

10537244

10552242

10564563

10594986

10600884

10604240

1423855_x_at

1435791_x_at

1436822_x_at

1453752_at

17351822

319195

4618419

4656511

4695748

4705426

4752384

4823383

4827854

4866947

4988545

5018547

5037749

5063816

5067447

5075026

5100067

5137657

5199491

5201898

5211179

5306700

5352128

5407783

5526508

99335_at

A_52_P123268

A_55_P1998461

GO:0000278

GO:0002181

GO:0003723

GO:0003735

GO:0005198

GO:0005515

GO:0005737

GO:0005829

GO:0005840

GO:0006412

GO:0015934

GO:0022625

GO:0022626

GO:0031672

GO:0043226

GO:0045202

GO:0070180

GO:0098793

GO:0098794

GO:0140236

GO:0140242

GO:1900087

GO:1990904

ILMN_1213781

ILMN_2677935

Msa.749.0_f_at

j05277_f_at

mMC023059

mMR027768

Participates

as a component of

Other forms of this molecule

Rpl17 [cytosol]

Inferred From

RPL17 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001002239.2, XP_006526059.1, XP_017173408.1

Ensembl

ENSMUSG00000062328, ENSMUSP00000157556, ENSMUST00000079716, ENSMUST00000237431, ENSMUSP00000078654

PRO

Q9CPR4

MGI

2448270

PDB

6SWA, 7LS2, 7CPV, 7CPU, 7LS1

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