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PSMC4 [cytosol]
Stable Identifier
R-MMU-68777
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
P54775
Locations in the PathwayBrowser
Expand all
Cell Cycle (Mus musculus)
Cell Cycle Checkpoints (Mus musculus)
G1/S DNA Damage Checkpoints (Mus musculus)
p53-Dependent G1/S DNA damage checkpoint (Mus musculus)
p53-Dependent G1 DNA Damage Response (Mus musculus)
Stabilization of p53 (Mus musculus)
Autodegradation of the E3 ubiquitin ligase COP1 (Mus musculus)
Proteasome mediated degradation of COP1 (Mus musculus)
26S proteasome [cytosol] (Mus musculus)
PSMC4 [cytosol] (Mus musculus)
p53-Independent G1/S DNA damage checkpoint (Mus musculus)
p53-Independent DNA Damage Response (Mus musculus)
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A (Mus musculus)
Proteolytic degradation of ubiquitinated-Cdc25A (Mus musculus)
26S proteasome [cytosol] (Mus musculus)
PSMC4 [cytosol] (Mus musculus)
G2/M Checkpoints (Mus musculus)
GTSE1 facilitates proteasome-mediated degradation of TP53 (Mus musculus)
26S proteasome [cytosol] (Mus musculus)
PSMC4 [cytosol] (Mus musculus)
Cell Cycle, Mitotic (Mus musculus)
M Phase (Mus musculus)
Mitotic Metaphase and Anaphase (Mus musculus)
Mitotic Anaphase (Mus musculus)
Separation of Sister Chromatids (Mus musculus)
Degradation of multiubiquitinated Securin (Mus musculus)
26S proteasome [cytosol] (Mus musculus)
PSMC4 [cytosol] (Mus musculus)
Mitotic G2-G2/M phases (Mus musculus)
G2/M Transition (Mus musculus)
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis (Mus musculus)
Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Mus musculus)
26S proteasome [cytosol] (Mus musculus)
PSMC4 [cytosol] (Mus musculus)
Proteasome-mediated degradation of PolyUb-FBXL7 (Mus musculus)
26S proteasome [cytosol] (Mus musculus)
PSMC4 [cytosol] (Mus musculus)
The role of GTSE1 in G2/M progression after G2 checkpoint (Mus musculus)
GTSE1 facilitates proteasome-mediated degradation of TP53 (Mus musculus)
26S proteasome [cytosol] (Mus musculus)
PSMC4 [cytosol] (Mus musculus)
Regulation of mitotic cell cycle (Mus musculus)
APC/C-mediated degradation of cell cycle proteins (Mus musculus)
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Mus musculus)
Degradation of multiubiquitinated cell cycle proteins (Mus musculus)
26S proteasome [cytosol] (Mus musculus)
PSMC4 [cytosol] (Mus musculus)
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Mus musculus)
APC/C:Cdc20 mediated degradation of mitotic proteins (Mus musculus)
APC/C:Cdc20 mediated degradation of Securin (Mus musculus)
Degradation of multiubiquitinated Securin (Mus musculus)
26S proteasome [cytosol] (Mus musculus)
PSMC4 [cytosol] (Mus musculus)
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint (Mus musculus)
Cdc20:Phospho-APC/C mediated degradation of Cyclin A (Mus musculus)
Degradation multiubiquitinated Cyclin A (Mus musculus)
26S proteasome [cytosol] (Mus musculus)
PSMC4 [cytosol] (Mus musculus)
S Phase (Mus musculus)
Synthesis of DNA (Mus musculus)
Switching of origins to a post-replicative state (Mus musculus)
CDK-mediated phosphorylation and removal of Cdc6 (Mus musculus)
Ubiquitinated Cdc6 is degraded by the proteasome (Mus musculus)
26S proteasome [cytosol] (Mus musculus)
PSMC4 [cytosol] (Mus musculus)
Orc1 removal from chromatin (Mus musculus)
Ubiquitinated Orc1 is degraded by the proteasome (Mus musculus)
26S proteasome [cytosol] (Mus musculus)
PSMC4 [cytosol] (Mus musculus)
Ubiquitin-dependent degradation of Cyclin D (Mus musculus)
Proteasome mediated degradation of Cyclin D1 (Mus musculus)
26S proteasome [cytosol] (Mus musculus)
PSMC4 [cytosol] (Mus musculus)
Cellular responses to stimuli (Mus musculus)
Cellular responses to stress (Mus musculus)
Cellular response to chemical stress (Mus musculus)
KEAP1-NFE2L2 pathway (Mus musculus)
26S proteasome degrades Ub-NFE2L2 (Mus musculus)
26S proteasome [cytosol] (Mus musculus)
PSMC4 [cytosol] (Mus musculus)
ub UBXN7 is degraded by the 26S proteasome (Mus musculus)
26S proteasome [cytosol] (Mus musculus)
PSMC4 [cytosol] (Mus musculus)
Cellular response to hypoxia (Mus musculus)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Mus musculus)
Proteasome proteolyzes ub-HIF-alpha (Mus musculus)
26S proteasome [cytosol] (Mus musculus)
PSMC4 [cytosol] (Mus musculus)
DNA Replication (Mus musculus)
Synthesis of DNA (Mus musculus)
Switching of origins to a post-replicative state (Mus musculus)
CDK-mediated phosphorylation and removal of Cdc6 (Mus musculus)
Ubiquitinated Cdc6 is degraded by the proteasome (Mus musculus)
26S proteasome [cytosol] (Mus musculus)
PSMC4 [cytosol] (Mus musculus)
Orc1 removal from chromatin (Mus musculus)
Ubiquitinated Orc1 is degraded by the proteasome (Mus musculus)
26S proteasome [cytosol] (Mus musculus)
PSMC4 [cytosol] (Mus musculus)
Gene expression (Transcription) (Mus musculus)
RNA Polymerase II Transcription (Mus musculus)
Generic Transcription Pathway (Mus musculus)
Transcriptional regulation by RUNX1 (Mus musculus)
RUNX1 regulates transcription of genes involved in differentiation of HSCs (Mus musculus)
26S proteasome degrades TP73 polyubiquitinated by ITCH (Mus musculus)
26S proteasome [cytosol] (Mus musculus)
PSMC4 [cytosol] (Mus musculus)
Immune System (Mus musculus)
Adaptive Immune System (Mus musculus)
Class I MHC mediated antigen processing & presentation (Mus musculus)
Antigen processing-Cross presentation (Mus musculus)
Cross-presentation of soluble exogenous antigens (endosomes) (Mus musculus)
Proteasomal clevage of exogenous antigen (Mus musculus)
26S proteasome [cytosol] (Mus musculus)
PSMC4 [cytosol] (Mus musculus)
Antigen processing: Ubiquitination & Proteasome degradation (Mus musculus)
Proteasomal cleavage of substrate (Mus musculus)
26S proteasome [cytosol] (Mus musculus)
PSMC4 [cytosol] (Mus musculus)
Signaling by the B Cell Receptor (BCR) (Mus musculus)
Downstream signaling events of B Cell Receptor (BCR) (Mus musculus)
Activation of NF-kappaB in B cells (Mus musculus)
Ubiquitinated IkB is degraded (Mus musculus)
26S proteasome [cytosol] (Mus musculus)
PSMC4 [cytosol] (Mus musculus)
TCR signaling (Mus musculus)
Downstream TCR signaling (Mus musculus)
26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Mus musculus)
26S proteasome [cytosol] (Mus musculus)
PSMC4 [cytosol] (Mus musculus)
Cytokine Signaling in Immune system (Mus musculus)
Signaling by Interleukins (Mus musculus)
Interleukin-1 family signaling (Mus musculus)
Interleukin-1 signaling (Mus musculus)
Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex (Mus musculus)
26S proteasome [cytosol] (Mus musculus)
PSMC4 [cytosol] (Mus musculus)
TNFR2 non-canonical NF-kB pathway (Mus musculus)
26Sproteasome degrades K48polyUb-NIK (Mus musculus)
26S proteasome [cytosol] (Mus musculus)
PSMC4 [cytosol] (Mus musculus)
NIK-->noncanonical NF-kB signaling (Mus musculus)
26S proteasome processes p-7S-p100:RELB to form p52:RELB (Mus musculus)
26S proteasome [cytosol] (Mus musculus)
PSMC4 [cytosol] (Mus musculus)
Protesomal degradation of K48polyUb-TRAF3 (Mus musculus)
26S proteasome [cytosol] (Mus musculus)
PSMC4 [cytosol] (Mus musculus)
Innate Immune System (Mus musculus)
C-type lectin receptors (CLRs) (Mus musculus)
CLEC7A (Dectin-1) signaling (Mus musculus)
26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Mus musculus)
26S proteasome [cytosol] (Mus musculus)
PSMC4 [cytosol] (Mus musculus)
Dectin-1 mediated noncanonical NF-kB signaling (Mus musculus)
26S proteasome processes p-7S-p100:RELB to form p52:RELB (Mus musculus)
26S proteasome [cytosol] (Mus musculus)
PSMC4 [cytosol] (Mus musculus)
Fc epsilon receptor (FCERI) signaling (Mus musculus)
FCERI mediated NF-kB activation (Mus musculus)
26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Mus musculus)
26S proteasome [cytosol] (Mus musculus)
PSMC4 [cytosol] (Mus musculus)
Metabolism (Mus musculus)
Metabolism of amino acids and derivatives (Mus musculus)
Metabolism of polyamines (Mus musculus)
Regulation of ornithine decarboxylase (ODC) (Mus musculus)
26S proteosome degrades ODC holoenzyme complex (Mus musculus)
26S proteasome [cytosol] (Mus musculus)
PSMC4 [cytosol] (Mus musculus)
Metabolism of RNA (Mus musculus)
Regulation of mRNA stability by proteins that bind AU-rich elements (Mus musculus)
AUF1 (hnRNP D0) binds and destabilizes mRNA (Mus musculus)
AUF1:mRNA complex is destroyed (Mus musculus)
26S proteasome [cytosol] (Mus musculus)
PSMC4 [cytosol] (Mus musculus)
Metabolism of proteins (Mus musculus)
Post-translational protein modification (Mus musculus)
Deubiquitination (Mus musculus)
UCH proteinases (Mus musculus)
ADRM1 binds 26S proteasome (Mus musculus)
26S proteasome [cytosol] (Mus musculus)
PSMC4 [cytosol] (Mus musculus)
ADRM1:26S proteasome [cytosol] (Mus musculus)
26S proteasome [cytosol] (Mus musculus)
PSMC4 [cytosol] (Mus musculus)
ADRM1:26S proteaseome binds UCHL5 (Mus musculus)
ADRM1:26S proteasome [cytosol] (Mus musculus)
26S proteasome [cytosol] (Mus musculus)
PSMC4 [cytosol] (Mus musculus)
ADRM1:26S proteasome:UCHL5 [cytosol] (Mus musculus)
ADRM1:26S proteasome [cytosol] (Mus musculus)
26S proteasome [cytosol] (Mus musculus)
PSMC4 [cytosol] (Mus musculus)
Ub-specific processing proteases (Mus musculus)
ADRM1:26S proteaseome binds USP14 (Mus musculus)
ADRM1:26S proteasome [cytosol] (Mus musculus)
26S proteasome [cytosol] (Mus musculus)
PSMC4 [cytosol] (Mus musculus)
ADRM1:26S proteasome:USP14 [cytosol] (Mus musculus)
ADRM1:26S proteasome [cytosol] (Mus musculus)
26S proteasome [cytosol] (Mus musculus)
PSMC4 [cytosol] (Mus musculus)
Neddylation (Mus musculus)
26S proteasome degrades HIFalpha (Mus musculus)
26S proteasome [cytosol] (Mus musculus)
PSMC4 [cytosol] (Mus musculus)
26S proteasome degrades Ub-NFE2L2 (Mus musculus)
26S proteasome [cytosol] (Mus musculus)
PSMC4 [cytosol] (Mus musculus)
26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates (Mus musculus)
26S proteasome [cytosol] (Mus musculus)
PSMC4 [cytosol] (Mus musculus)
NEDD8,UBD:NUB1:26S proteasome [cytosol] (Mus musculus)
26S proteasome [cytosol] (Mus musculus)
PSMC4 [cytosol] (Mus musculus)
NEDD8 and UBD bind NUB1 and the 26S proteasome (Mus musculus)
26S proteasome [cytosol] (Mus musculus)
PSMC4 [cytosol] (Mus musculus)
NEDD8,UBD:NUB1:26S proteasome [cytosol] (Mus musculus)
26S proteasome [cytosol] (Mus musculus)
PSMC4 [cytosol] (Mus musculus)
ub UBXN7 is degraded by the 26S proteasome (Mus musculus)
26S proteasome [cytosol] (Mus musculus)
PSMC4 [cytosol] (Mus musculus)
Signal Transduction (Mus musculus)
Intracellular signaling by second messengers (Mus musculus)
PIP3 activates AKT signaling (Mus musculus)
PTEN Regulation (Mus musculus)
Regulation of PTEN stability and activity (Mus musculus)
Proteasome degrades polyubiquitinated PTEN (Mus musculus)
26S proteasome [cytosol] (Mus musculus)
PSMC4 [cytosol] (Mus musculus)
MAPK family signaling cascades (Mus musculus)
MAPK1/MAPK3 signaling (Mus musculus)
RAF/MAP kinase cascade (Mus musculus)
Regulation of RAS by GAPs (Mus musculus)
NF1 is degraded by the proteasome (Mus musculus)
26S proteasome [cytosol] (Mus musculus)
PSMC4 [cytosol] (Mus musculus)
MAPK6/MAPK4 signaling (Mus musculus)
MAPK6 is degraded by the 26S proteasome (Mus musculus)
26S proteasome [cytosol] (Mus musculus)
PSMC4 [cytosol] (Mus musculus)
Signaling by Hedgehog (Mus musculus)
Hedgehog 'off' state (Mus musculus)
Degradation of GLI1 by the proteasome (Mus musculus)
GLI1 is degraded by the proteasome after ubiquitination by ITCH (Mus musculus)
26S proteasome [cytosol] (Mus musculus)
PSMC4 [cytosol] (Mus musculus)
GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP (Mus musculus)
26S proteasome [cytosol] (Mus musculus)
PSMC4 [cytosol] (Mus musculus)
GLI3 is processed to GLI3R by the proteasome (Mus musculus)
GLI3 is partially degraded by the proteasome to yield the GLI3 repressor (Mus musculus)
26S proteasome [cytosol] (Mus musculus)
PSMC4 [cytosol] (Mus musculus)
Hedgehog 'on' state (Mus musculus)
ub-GLI is degraded by the proteasome (Mus musculus)
26S proteasome [cytosol] (Mus musculus)
PSMC4 [cytosol] (Mus musculus)
Hedgehog ligand biogenesis (Mus musculus)
Hh C-terminal fragments are degraded by the proteasome (Mus musculus)
26S proteasome [cytosol] (Mus musculus)
PSMC4 [cytosol] (Mus musculus)
Signaling by WNT (Mus musculus)
Beta-catenin independent WNT signaling (Mus musculus)
PCP/CE pathway (Mus musculus)
Asymmetric localization of PCP proteins (Mus musculus)
PRICKLE1 is degraded by the proteasome (Mus musculus)
26S proteasome [cytosol] (Mus musculus)
PSMC4 [cytosol] (Mus musculus)
Degradation of beta-catenin by the destruction complex (Mus musculus)
Degradation of ubiquitinated beta catenin by the proteasome (Mus musculus)
26S proteasome [cytosol] (Mus musculus)
PSMC4 [cytosol] (Mus musculus)
TCF dependent signaling in response to WNT (Mus musculus)
Degradation of AXIN (Mus musculus)
Ub-RibC-AXIN is degraded by the proteasome (Mus musculus)
26S proteasome [cytosol] (Mus musculus)
PSMC4 [cytosol] (Mus musculus)
Ubiquitinated AXIN is degraded by the proteasome (Mus musculus)
26S proteasome [cytosol] (Mus musculus)
PSMC4 [cytosol] (Mus musculus)
Degradation of DVL (Mus musculus)
Ubiquitinated DVL is degraded by the proteasome (Mus musculus)
26S proteasome [cytosol] (Mus musculus)
PSMC4 [cytosol] (Mus musculus)
Ubiquitinated DVL1 is degraded by the proteasome (Mus musculus)
26S proteasome [cytosol] (Mus musculus)
PSMC4 [cytosol] (Mus musculus)
Transport of small molecules (Mus musculus)
ABC-family proteins mediated transport (Mus musculus)
misfolded CFTR is degraded by the 26S proteasome (Mus musculus)
26S proteasome [cytosol] (Mus musculus)
PSMC4 [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:P54775
Reference Genes
BioGPS Gene:23996
ENSEMBL:ENSMUSG00000030603
ENSEMBL:ENSMUSG00000030603.17
KEGG Gene (Mus musculus):23996
Monarch:23996
NCBI Gene:23996
UCSC:P54775
Reference Transcript
RefSeq:NM_011874.2
Other Identifiers
10561356
1416290_a_at
1416291_at
17488352
23996
4337861
4364608
4486018
4662226
4800004
4990407
4991433
5019133
5259593
5274616
5299391
5416719
5465609
5469343
A_52_P10254
A_66_P108467
GE42695
GO:0000166
GO:0000502
GO:0001824
GO:0003824
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0008540
GO:0016234
GO:0016787
GO:0016887
GO:0022624
GO:0030163
GO:0031597
GO:0036402
GO:0043161
GO:0043226
GO:0045202
GO:0048856
GO:0140657
GO:1901800
ILMN_1238082
ILMN_2632349
ILMN_2728516
l76223_s_at
mMC016133
Participates
as a component of
26S proteasome [cytosol] (Mus musculus)
Other forms of this molecule
PSMC4 [nucleoplasm]
Inferred From
PSMC4 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_036004.2
Ensembl
ENSMUSP00000032824
,
ENSMUST00000032824
,
ENSMUSG00000030603
PRO
P54775
MGI
1346093
PDB
3AJI
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