Reactome | ORC5 [nucleoplasm]

ORC5 [nucleoplasm]

Stable Identifier

R-MMU-68516

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

Q9WUV0

Locations in the PathwayBrowser

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Cell Cycle (Mus musculus)

- Cell Cycle Checkpoints (Mus musculus)
  - G2/M Checkpoints (Mus musculus)
    - Activation of ATR in response to replication stress (Mus musculus)
      - Activation of claspin (Mus musculus)
        
        Cdc45:CDK:DDK:Mcm10:Activated claspin:pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        ORC:origin of replication [nucleoplasm] (Mus musculus)
        
        ORC5 [nucleoplasm] (Mus musculus)
        
        Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        ORC:origin of replication [nucleoplasm] (Mus musculus)
        
        ORC5 [nucleoplasm] (Mus musculus)
      - Loading of claspin onto DNA during replication origin firing (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        ORC:origin of replication [nucleoplasm] (Mus musculus)
        
        ORC5 [nucleoplasm] (Mus musculus)
        
        Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        ORC:origin of replication [nucleoplasm] (Mus musculus)
        
        ORC5 [nucleoplasm] (Mus musculus)
- Cell Cycle, Mitotic (Mus musculus)
  - Mitotic G1 phase and G1/S transition (Mus musculus)
    - G1/S Transition (Mus musculus)
      - Activation of the pre-replicative complex (Mus musculus)
        
        CDK and DDK associate with the Mcm10:pre-replicative complex (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        ORC:origin of replication [nucleoplasm] (Mus musculus)
        
        ORC5 [nucleoplasm] (Mus musculus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        ORC:origin of replication [nucleoplasm] (Mus musculus)
        
        ORC5 [nucleoplasm] (Mus musculus)
        
        Cdc45 associates with the pre-replicative complex at the origin (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        ORC:origin of replication [nucleoplasm] (Mus musculus)
        
        ORC5 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        ORC:origin of replication [nucleoplasm] (Mus musculus)
        
        ORC5 [nucleoplasm] (Mus musculus)
        
        Cdt1 is displaced from the pre-replicative complex. (Mus musculus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        ORC:origin of replication [nucleoplasm] (Mus musculus)
        
        ORC5 [nucleoplasm] (Mus musculus)
        
        MCM10:pre-replicative complex [nucleoplasm] (Mus musculus)
        
        pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        ORC:origin of replication [nucleoplasm] (Mus musculus)
        
        ORC5 [nucleoplasm] (Mus musculus)
        
        DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        ORC:origin of replication [nucleoplasm] (Mus musculus)
        
        ORC5 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        ORC:origin of replication [nucleoplasm] (Mus musculus)
        
        ORC5 [nucleoplasm] (Mus musculus)
        
        DNA polymerase alpha:primase binds at the origin (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        ORC:origin of replication [nucleoplasm] (Mus musculus)
        
        ORC5 [nucleoplasm] (Mus musculus)
        
        DNA polymerase epsilon binds at the origin (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        ORC:origin of replication [nucleoplasm] (Mus musculus)
        
        ORC5 [nucleoplasm] (Mus musculus)
        
        Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Mus musculus)
        
        MCM10:pre-replicative complex [nucleoplasm] (Mus musculus)
        
        pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        ORC:origin of replication [nucleoplasm] (Mus musculus)
        
        ORC5 [nucleoplasm] (Mus musculus)
        
        pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        ORC:origin of replication [nucleoplasm] (Mus musculus)
        
        ORC5 [nucleoplasm] (Mus musculus)
  - S Phase (Mus musculus)
    - Synthesis of DNA (Mus musculus)
      - Switching of origins to a post-replicative state (Mus musculus)
        
        Orc1 removal from chromatin (Mus musculus)
        
        Orc1 is phosphorylated by cyclin A/CDK2 (Mus musculus)
        
        pre-replicative complex (Orc1-minus) [nucleoplasm] (Mus musculus)
        
        ORC5 [nucleoplasm] (Mus musculus)
        
        pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        ORC:origin of replication [nucleoplasm] (Mus musculus)
        
        ORC5 [nucleoplasm] (Mus musculus)

DNA Replication (Mus musculus)

- DNA Replication Pre-Initiation (Mus musculus)
  - Activation of the pre-replicative complex (Mus musculus)
    - CDK and DDK associate with the Mcm10:pre-replicative complex (Mus musculus)
      - CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        ORC:origin of replication [nucleoplasm] (Mus musculus)
        
        ORC5 [nucleoplasm] (Mus musculus)
      - MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        ORC:origin of replication [nucleoplasm] (Mus musculus)
        
        ORC5 [nucleoplasm] (Mus musculus)
    - Cdc45 associates with the pre-replicative complex at the origin (Mus musculus)
      - CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        ORC:origin of replication [nucleoplasm] (Mus musculus)
        
        ORC5 [nucleoplasm] (Mus musculus)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        ORC:origin of replication [nucleoplasm] (Mus musculus)
        
        ORC5 [nucleoplasm] (Mus musculus)
    - Cdt1 is displaced from the pre-replicative complex. (Mus musculus)
      - MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        ORC:origin of replication [nucleoplasm] (Mus musculus)
        
        ORC5 [nucleoplasm] (Mus musculus)
      - MCM10:pre-replicative complex [nucleoplasm] (Mus musculus)
        
        pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        ORC:origin of replication [nucleoplasm] (Mus musculus)
        
        ORC5 [nucleoplasm] (Mus musculus)
    - DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Mus musculus)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        ORC:origin of replication [nucleoplasm] (Mus musculus)
        
        ORC5 [nucleoplasm] (Mus musculus)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        ORC:origin of replication [nucleoplasm] (Mus musculus)
        
        ORC5 [nucleoplasm] (Mus musculus)
    - DNA polymerase alpha:primase binds at the origin (Mus musculus)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        ORC:origin of replication [nucleoplasm] (Mus musculus)
        
        ORC5 [nucleoplasm] (Mus musculus)
    - DNA polymerase epsilon binds at the origin (Mus musculus)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        ORC:origin of replication [nucleoplasm] (Mus musculus)
        
        ORC5 [nucleoplasm] (Mus musculus)
    - Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Mus musculus)
      - MCM10:pre-replicative complex [nucleoplasm] (Mus musculus)
        
        pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        ORC:origin of replication [nucleoplasm] (Mus musculus)
        
        ORC5 [nucleoplasm] (Mus musculus)
      - pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        ORC:origin of replication [nucleoplasm] (Mus musculus)
        
        ORC5 [nucleoplasm] (Mus musculus)
  - Assembly of the pre-replicative complex (Mus musculus)
    - Assembly of the ORC complex at the origin of replication (Mus musculus)
      - Formation of ORC(1-5) complex (Mus musculus)
        
        ORC(1-5):origin of replication [nucleoplasm] (Mus musculus)
        
        ORC(1-5) [nucleoplasm] (Mus musculus)
        
        ORC(2-5) [nucleoplasm] (Mus musculus)
        
        ORC2:ORC3:ORC5 [nucleoplasm] (Mus musculus)
        
        ORC5 [nucleoplasm] (Mus musculus)
        
        ORC(2-5) [nucleoplasm] (Mus musculus)
        
        ORC2:ORC3:ORC5 [nucleoplasm] (Mus musculus)
        
        ORC5 [nucleoplasm] (Mus musculus)
      - Formation of ORC(1-6) complex (Mus musculus)
        
        ORC(1-5):origin of replication [nucleoplasm] (Mus musculus)
        
        ORC(1-5) [nucleoplasm] (Mus musculus)
        
        ORC(2-5) [nucleoplasm] (Mus musculus)
        
        ORC2:ORC3:ORC5 [nucleoplasm] (Mus musculus)
        
        ORC5 [nucleoplasm] (Mus musculus)
        
        ORC(1-6):origin of replication [nucleoplasm] (Mus musculus)
        
        ORC(1-5):origin of replication [nucleoplasm] (Mus musculus)
        
        ORC(1-5) [nucleoplasm] (Mus musculus)
        
        ORC(2-5) [nucleoplasm] (Mus musculus)
        
        ORC2:ORC3:ORC5 [nucleoplasm] (Mus musculus)
        
        ORC5 [nucleoplasm] (Mus musculus)
      - Formation of ORC(2-5) complex (Mus musculus)
        
        ORC(2-5) [nucleoplasm] (Mus musculus)
        
        ORC2:ORC3:ORC5 [nucleoplasm] (Mus musculus)
        
        ORC5 [nucleoplasm] (Mus musculus)
        
        ORC2:ORC3:ORC5 [nucleoplasm] (Mus musculus)
        
        ORC5 [nucleoplasm] (Mus musculus)
      - ORC5 binds ORC2:ORC3 (Mus musculus)
        
        ORC2:ORC3:ORC5 [nucleoplasm] (Mus musculus)
        
        ORC5 [nucleoplasm] (Mus musculus)
        
        ORC5 [nucleoplasm] (Mus musculus)
    - CDC6 association with the ORC:origin complex (Mus musculus)
      - CDC6 association with ORC(1-6) at replication origins (Mus musculus)
        
        ORC(1-6):CDC6:origin of replication [nucleoplasm] (Mus musculus)
        
        ORC(1-6):origin of replication [nucleoplasm] (Mus musculus)
        
        ORC(1-5):origin of replication [nucleoplasm] (Mus musculus)
        
        ORC(1-5) [nucleoplasm] (Mus musculus)
        
        ORC(2-5) [nucleoplasm] (Mus musculus)
        
        ORC2:ORC3:ORC5 [nucleoplasm] (Mus musculus)
        
        ORC5 [nucleoplasm] (Mus musculus)
        
        ORC(1-6):origin of replication [nucleoplasm] (Mus musculus)
        
        ORC(1-5):origin of replication [nucleoplasm] (Mus musculus)
        
        ORC(1-5) [nucleoplasm] (Mus musculus)
        
        ORC(2-5) [nucleoplasm] (Mus musculus)
        
        ORC2:ORC3:ORC5 [nucleoplasm] (Mus musculus)
        
        ORC5 [nucleoplasm] (Mus musculus)
- Synthesis of DNA (Mus musculus)
  - Switching of origins to a post-replicative state (Mus musculus)
    - Orc1 removal from chromatin (Mus musculus)
      - Orc1 is phosphorylated by cyclin A/CDK2 (Mus musculus)
        
        pre-replicative complex (Orc1-minus) [nucleoplasm] (Mus musculus)
        
        ORC5 [nucleoplasm] (Mus musculus)
        
        pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        ORC:origin of replication [nucleoplasm] (Mus musculus)
        
        ORC5 [nucleoplasm] (Mus musculus)

External Reference Information

External Reference

UniProt:Q9WUV0

Reference Genes

BioGPS Gene:26429

ENSEMBL:ENSMUSG00000029012

ENSEMBL:ENSMUSG00000029012.12

KEGG Gene (Mus musculus):26429

Monarch:26429

NCBI Gene:26429

UCSC:Q9WUV0

Reference Transcript

RefSeq:NM_011959.2

Other Identifiers

100894_at

10528457

1415830_at

17445996

26429

4325048

4537230

4542086

4543225

4603655

4632902

4657817

4690265

4757808

4838045

4904679

5074835

5101892

5114970

5153062

5256608

5296712

5329762

5472122

5555138

5577880

A_51_P214825

A_55_P2638098

GO:0000166

GO:0000228

GO:0000785

GO:0000808

GO:0003677

GO:0003688

GO:0005524

GO:0005634

GO:0005654

GO:0005664

GO:0005694

GO:0005829

GO:0006260

GO:0006270

GO:0006275

GO:0043226

ILMN_1221363

ILMN_1253844

aa290362_at

mMC025998

Participates

as a component of

as an input of

ORC5 binds ORC2:ORC3 (Mus musculus)

Inferred From

ORC5 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_036089.1

Ensembl

ENSMUSP00000030872, ENSMUST00000030872, ENSMUSG00000029012

PRO

Q9WUV0

MGI

1347044

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