Nudt7 hydrolyses CoA-SH to 3',5'-ADP and PPANT

Stable Identifier
R-MMU-6810452
Type
Reaction [transition]
Species
Mus musculus
Compartment
peroxisomal matrix
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Nudt7 hydrolyses CoA-SH to 3',5'-ADP and PPANT
Coenzyme A (CoASH) is a necessary cofactor for the oxidation of lipids in peroxisomes. Peroxisomal coenzyme A diphosphatase (Nudt7) mediates the cleavage of CoA (and CoA esters and oxidised CoA) to produce 3',5'-ADP and 4'-phosphopantetheine (PPANT) and is suggested to be involved in the regulation of peroxisomal CoASH levels (Gasmi et al. 2001, Reilly et al. 2008).
Literature References
PubMed ID Title Journal Year
18799520 The nudix hydrolase 7 is an Acyl-CoA diphosphatase involved in regulating peroxisomal coenzyme A homeostasis

Reilly, SJ, Alexson, SE, Tillander, V, Hunt, MC, Ofman, R

J. Biochem. 2008
11415433 The mouse Nudt7 gene encodes a peroxisomal nudix hydrolase specific for coenzyme A and its derivatives

Gasmi, L, McLennan, AG

Biochem. J. 2001
Participants
Input
Output
Catalyst Activity

CoA pyrophosphatase activity of Nudt7 [peroxisomal matrix]

Physical Entity
Nudt7 [peroxisomal matrix] (Mus musculus)
Activity
CoA pyrophosphatase activity (GO:0010945)
Orthologous Events
NUDT7 hydrolyses CoA-SH to 3',5'-ADP and PPANT (Homo sapiens)
Authored
Jassal, B  (2015-11-17)
Reviewed
D'Eustachio, P  (2016-01-11)
Created
Jassal, B  (2015-11-17)
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