Hoxb2 chromatin is activated

Stable Identifier
Reaction [omitted]
Mus musculus
SVG |   | PPTX  | SBGN
Hoxb2 chromatin is activated

As inferred from mouse embryonic stem cells activated by retinoic acid (Kashyap et al. 2011, Mazzoni et al. 2013) and human cell lines, methylation at lysine-27 of histone H3 (H3K27me3) is lost (Kashyap et al. 2011, Mazzoni et al. 2013), Polycomb repressive complex 2 (PRC2) is lost (Mazzoni et al. 2013), and methylation at lysine-4 (H3K4me3) is gained (Kashyap et al. 2011). The Mll2 complex methylates H3K4 at Hoxb2 in fibroblasts (Wang et al. 2009). In human cells, the histone demethylase KDM6A (UTX) binds HOXB2 chromatin and demethylates H3K27me3. Other factors may also participate in demethylation.

Literature References
PubMed ID Title Journal Year
19703992 Global analysis of H3K4 methylation defines MLL family member targets and points to a role for MLL1-mediated H3K4 methylation in the regulation of transcriptional initiation by RNA polymerase II

Ge, K, Gogol, M, Wiedemann, LM, Seidel, C, Guo, H, Smith, ER, Alexander, T, Sanderson, BW, Lin, C, Wang, P, Wu, M, Shilatifard, A, Krumlauf, R

Mol. Cell. Biol. 2009
21087926 Epigenomic reorganization of the clustered Hox genes in embryonic stem cells induced by retinoic acid

Kashyap, V, Brenet, F, Viale, A, Funk, P, Gudas, LJ, Scandura, JM

J. Biol. Chem. 2011
23955559 Saltatory remodeling of Hox chromatin in response to rostrocaudal patterning signals

Boyer, LA, Thornton, SR, Gifford, DK, Young, RA, McCuine, S, Mazzoni, EO, Patel, T, Peljto, M, Wichterle, H, Reeder, C, Mahony, S

Nat. Neurosci. 2013
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