Reactome | Ice1 [nucleoplasm]

Ice1 [nucleoplasm]

Stable Identifier

R-MMU-6807433

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

ICE1, E9Q286

Locations in the PathwayBrowser

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Gene expression (Transcription) (Mus musculus)

- RNA Polymerase II Transcription (Mus musculus)
  - RNA polymerase II transcribes snRNA genes (Mus musculus)
    - CBCAP complex binds 7-methylguanosine cap of snRNA (Mus musculus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Mus musculus)
        
        LEC [nucleoplasm] (Mus musculus)
        
        Ice1 [nucleoplasm] (Mus musculus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Mus musculus)
        
        LEC [nucleoplasm] (Mus musculus)
        
        Ice1 [nucleoplasm] (Mus musculus)
    - Integrator complex processes the 3' end of snRNA (Mus musculus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Mus musculus)
        
        LEC [nucleoplasm] (Mus musculus)
        
        Ice1 [nucleoplasm] (Mus musculus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Mus musculus)
        
        LEC [nucleoplasm] (Mus musculus)
        
        Ice1 [nucleoplasm] (Mus musculus)
    - Pre-snRNA is elongated and capped with 7-methylguanosine (Mus musculus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Mus musculus)
        
        LEC [nucleoplasm] (Mus musculus)
        
        Ice1 [nucleoplasm] (Mus musculus)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Mus musculus)
        
        LEC [nucleoplasm] (Mus musculus)
        
        Ice1 [nucleoplasm] (Mus musculus)
    - Pre-snRNA transcript initiation, Integrator binding, LEC binding (Mus musculus)
      - LEC [nucleoplasm] (Mus musculus)
        
        Ice1 [nucleoplasm] (Mus musculus)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Mus musculus)
        
        LEC [nucleoplasm] (Mus musculus)
        
        Ice1 [nucleoplasm] (Mus musculus)

External Reference Information

External Reference

UniProt:E9Q286

Gene Names

Ice1

Reference Genes

BioGPS Gene:218333 Ice1

ENSEMBL:ENSMUSG00000034525

ENSEMBL:ENSMUSG00000034525.8 Ice1

KEGG Gene (Mus musculus):218333 Ice1

Monarch:218333 Ice1

NCBI Gene:218333 Ice1

UCSC:E9Q286 Ice1

Reference Transcript

RefSeq:NM_144837.3 Ice1

Other Identifiers

10410465

1424071_s_at

1451221_at

17294167

218333

4352898

4514255

4523098

4529905

4616267

4629807

4648642

4755545

4787352

4826468

4832720

4846882

4882807

4896868

4944254

4996202

5032122

5100619

5444838

5490950

5517364

5531708

5547457

5594547

94979_at

A_30_P01018966

A_30_P01028810

A_51_P232439

A_66_P128930

GE102730

GE130025

GO:0000791

GO:0005634

GO:0005654

GO:0005694

GO:0006351

GO:0006355

GO:0006886

GO:0008023

GO:0015030

GO:0016073

GO:0016604

GO:0030674

GO:0031334

GO:0035363

GO:0042795

GO:0042796

GO:0043226

GO:0045945

GO:0060090

GO:0065003

GO:0090316

ILMN_1230422

ILMN_1259805

ILMN_2625645

mMC018783

mMC021557

w70819_s_at

Participates

as a component of

LEC [nucleoplasm] (Mus musculus)

Inferred From

ICE1 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_659086.2

Ensembl

ENSMUSG00000034525, ENSMUST00000043493, ENSMUSP00000036482

PRO

E9Q286

MGI

2385865

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