Nr2e1 represses Pten transcription

Stable Identifier
R-MMU-6807098
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Nr2e1 represses Pten transcription
Mouse Nr2e1 (Tlx) binds the evolutionarily conserved Tlx site in the mouse Pten promoter and represses Pten transcription. Formation of a complex between Nr2e1 and Atn1 (Atrophin-1) is needed for Nr2e1-mediated transcriptional repression (Zhang et al. 2006).
Literature References
PubMed ID Title Journal Year
16702404 Nuclear receptor TLX prevents retinal dystrophy and recruits the corepressor atrophin1

Zhang, CL, Zou, Y, Gage, FH, Evans, RM, Yu, RT

Genes Dev. 2006
Participants
Input
Output
This event is regulated
Negatively by
Regulator
Nr2e1:Atn1:Pten Gene [nucleoplasm] (Mus musculus)
Orthologous Events
PTEN gene transcription is stimulated by TP53, EGR1, PPARG, ATF2, MAF1, and inhibited by NR2E1, SALL4, MECOM, SNAI1, SNAI2, JUN (Homo sapiens)
Authored
Orlic-Milacic, M  (2016-09-14)
Reviewed
Chuang, LS  (2016-12-20)
Ito, Y  (2016-12-20)
Created
Orlic-Milacic, M  (2015-10-29)
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