Hvem induses Btla phosphorylation

Stable Identifier
R-MMU-6790089
Type
Reaction [omitted]
Species
Mus musculus
Compartment
ReviewStatus
5/5
General
SVG |   | PPTX  | SBGN
Hvem induses Btla phosphorylation
Binding of HVEM to BTLA induces tyrosine phosphorylation of BTLA on three cytoplasmic tyrosines. The phosphorylated tyrosine Y274 and 299 ( Y257 and 282 in human BTLA) associate with tyrosine phosphatase SHP2 and down regulate proximal TCR signalling. Phosphorylated Y245 (Y226 in human BTLA) in BTLA associates with growth receptor bound 2 (GRB2) (Murphy et al. 2006).
Literature References
PubMed ID Title Journal Year
12796776 BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1

Hurchla, MA, Fallarino, F, Zimmerman, N, Sedý, JR, Gavrieli, M, Loftin, SK, Zang, X, Murphy, KM, Sim, J, Murphy, TL, Russell, JH, Allison, JP, Yang, J, Watanabe, N

Nat Immunol 2003
16932752 Balancing co-stimulation and inhibition with BTLA and HVEM

Sedý, JR, Nelson, CA, Murphy, KM

Nat Rev Immunol 2006
Participants
Catalyst Activity

protein tyrosine kinase activity of unknown kinase [cytosol]

Orthologous Events
Authored
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