Reactome | Flt3lg [extracellular region]

Flt3lg [extracellular region]

Stable Identifier

R-MMU-6786793

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

extracellular region

Synonyms

FLT3LG, P49772

Locations in the PathwayBrowser

Expand all

Signal Transduction (Mus musculus)

- Intracellular signaling by second messengers (Mus musculus)
  - PIP3 activates AKT signaling (Mus musculus)
    - Negative regulation of the PI3K/AKT network (Mus musculus)
      - PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Mus musculus)
        
        PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
        
        Activator:PI3K [plasma membrane] (Mus musculus)
        
        Active FLT3:GRB2:p-Y GAB2:PI3K [plasma membrane] (Mus musculus)
        
        Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Mus musculus)
        
        Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Mus musculus)
        
        Active FLT3: GRB2 [plasma membrane] (Mus musculus)
        
        Active FLT3 [plasma membrane] (Mus musculus)
        
        FLT3LG dimer [extracellular region] (Mus musculus)
        
        Flt3lg [extracellular region] (Mus musculus)
    - PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
      - Activator:PI3K [plasma membrane] (Mus musculus)
        
        Active FLT3:GRB2:p-Y GAB2:PI3K [plasma membrane] (Mus musculus)
        
        Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Mus musculus)
        
        Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Mus musculus)
        
        Active FLT3: GRB2 [plasma membrane] (Mus musculus)
        
        Active FLT3 [plasma membrane] (Mus musculus)
        
        FLT3LG dimer [extracellular region] (Mus musculus)
        
        Flt3lg [extracellular region] (Mus musculus)
- MAPK family signaling cascades (Mus musculus)
  - MAPK1/MAPK3 signaling (Mus musculus)
    - RAF/MAP kinase cascade (Mus musculus)
      - RAS GEFs promote RAS nucleotide exchange (Mus musculus)
        
        RAS GEFs [plasma membrane] (Mus musculus)
        
        Active FLT3:GRB2:SOS1 [plasma membrane] (Mus musculus)
        
        Active FLT3: GRB2 [plasma membrane] (Mus musculus)
        
        Active FLT3 [plasma membrane] (Mus musculus)
        
        FLT3LG dimer [extracellular region] (Mus musculus)
        
        Flt3lg [extracellular region] (Mus musculus)
- Signaling by Receptor Tyrosine Kinases (Mus musculus)
  - Signaling by Insulin receptor (Mus musculus)
    - Insulin receptor signalling cascade (Mus musculus)
      - IRS-mediated signalling (Mus musculus)
        
        PI3K Cascade (Mus musculus)
        
        PI3K-containing complexes phosphorylate PIP2 to PIP3 (Mus musculus)
        
        PI3K-containing complexes [cytosol] (Mus musculus)
        
        Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Mus musculus)
        
        Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Mus musculus)
        
        Active FLT3: GRB2 [plasma membrane] (Mus musculus)
        
        Active FLT3 [plasma membrane] (Mus musculus)
        
        FLT3LG dimer [extracellular region] (Mus musculus)
        
        Flt3lg [extracellular region] (Mus musculus)
  - Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Mus musculus)
    - IGF1R signaling cascade (Mus musculus)
      - IRS-related events triggered by IGF1R (Mus musculus)
        
        IRS-mediated signalling (Mus musculus)
        
        PI3K Cascade (Mus musculus)
        
        PI3K-containing complexes phosphorylate PIP2 to PIP3 (Mus musculus)
        
        PI3K-containing complexes [cytosol] (Mus musculus)
        
        Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Mus musculus)
        
        Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Mus musculus)
        
        Active FLT3: GRB2 [plasma membrane] (Mus musculus)
        
        Active FLT3 [plasma membrane] (Mus musculus)
        
        FLT3LG dimer [extracellular region] (Mus musculus)
        
        Flt3lg [extracellular region] (Mus musculus)

External Reference Information

External Reference

UniProt:P49772 Flt3lg

Gene Names

Flt3lg, Flt3l

Chain

signal peptide:1-26, chain:27-232

Reference Genes

BioGPS Gene:14256 Flt3lg

CTD Gene:14256 Flt3lg

ENSEMBL:ENSMUSG00000110206.2 Flt3lg

KEGG Gene (Mus musculus):14256 Flt3lg

Monarch:14256 Flt3lg

NCBI Gene:14256 Flt3lg

UCSC:P49772 Flt3lg

Reference Transcript

RefSeq:NM_013520.3 Flt3lg

Other Identifiers

102929_s_at

10563116

1422115_a_at

14256

17490628

4522484

4535706

4540052

4589377

4595606

4627029

4634714

4899168

4900871

5053493

5350423

5432736

5438854

5568470

5616700

A_51_P374337

A_52_P644690

A_55_P2145506

GO:0001779

GO:0001934

GO:0002376

GO:0003824

GO:0005125

GO:0005576

GO:0005615

GO:0005886

GO:0006351

GO:0006355

GO:0007165

GO:0008284

GO:0009897

GO:0009986

GO:0012501

GO:0016020

GO:0016301

GO:0016310

GO:0016740

GO:0023052

GO:0030098

GO:0030154

GO:0030885

GO:0030971

GO:0032819

GO:0032825

GO:0035162

GO:0036211

GO:0045663

GO:0045787

GO:0045944

GO:0048018

GO:0048856

GO:0048873

GO:0071864

GO:0071866

GO:0090290

GO:0098772

GO:1901741

ILMN_2600397

mMC017476

u29875_s_at

Participates

as a component of

FLT3LG dimer [extracellular region] (Mus musculus)

Other forms of this molecule

Flt3lg [cytosol]

Flt3lg [extracellular region]

Inferred From

FLT3LG [extracellular region] (Homo sapiens)

Cross References

RefSeq

NP_038548.3

Ensembl

ENSMUST00000209238, ENSMUST00000146760, ENSMUSP00000123506, ENSMUST00000211246, ENSMUSP00000148156, ENSMUSP00000147278, ENSMUSG00000110206

PRO

P49772

MGI

95560

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