Apoa4 gene,Apoa5 gene,Apoc2 gene,Cidec gene,Fgf21 gene transcription and traduction to Apoa4,Apoa5,Apoc2,Cidec,Fgf21

Stable Identifier
R-MMU-6784616
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Apoa4 gene,Apoa5 gene,Apoc2 gene,Cidec gene,Fgf21 gene transcription and traduction to Apoa4,Apoa5,Apoc2,Cidec,Fgf21
Crebh(1-?) enters the nucleoplasm and induces the expression of APOA4, APOA5, APOC2, CIDEC and FGF21 (Lee et al. 2011). APOA4, APOA5 and APOC2 are known to augment lipoprotein lipase (LPL) activity. LPL is bound to the vascular endothelium, and hydrolyzes chylomicron and VLDL- associated TG to facilitate the transport of hydrolyzed fatty acids to peripheral cells. Patients with genetic defects in AOPC2, APOA5 or LPL display high circulating TG levels due to impaired TG clearance. Identification of APOA4, APOA5 and APOC2 as CREB-H target genes suggests that CREB-H might be involved in TG catabolism. CREB-H also strongly induces FGF21, a liver expressed hormone that has antidiabetic and TG- lowering effects, and CIDEC which encodes a lipid droplet-associated protein (Lee 2012).
Literature References
PubMed ID Title Journal Year
22262056 The role of CREB-H transcription factor in triglyceride metabolism

Lee, AH

Curr. Opin. Lipidol. 2012
21666694 The transcription factor cyclic AMP-responsive element-binding protein H regulates triglyceride metabolism

Glimcher, LH, Brown, JD, Johansen, CT, Wang, J, Duncan, SA, Lee, AH, Lee, JH, Giannikopoulos, P, Hegele, RA, Plutzky, J

Nat. Med. 2011
Participants
Input
Output
This event is regulated
Positively by
Regulator
Creb3l3(1-?) [nucleoplasm] (Mus musculus)
Orthologous Events
APOA4,APOA5,APOC2,CIDEC,FGF21 genes express APOA4,APOA5,APOC2,CIDEC,FGF21 proteins (Homo sapiens)
Authored
Sanchis, A  (2015-05-12)
Reviewed
D'Eustachio, P  (2016-04-20)
Created
Sanchis, A  (2015-06-22)
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