Reactome | Ndufa3 [mitochondrial inner membrane]

Ndufa3 [mitochondrial inner membrane]

Stable Identifier

R-MMU-60180

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

mitochondrial inner membrane

Synonyms

NDUFA3, Q9CQ91

Locations in the PathwayBrowser

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Metabolism (Mus musculus)

- Aerobic respiration and respiratory electron transport (Mus musculus)
  - Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (Mus musculus)
    - Respiratory electron transport (Mus musculus)
      - Complex I biogenesis (Mus musculus)
        
        Intermediate 1 binds HP subcomplex to form Intermediate 2 (Mus musculus)
        
        HP subcomplex [mitochondrial inner membrane] (Mus musculus)
        
        Ndufa3 [mitochondrial inner membrane] (Mus musculus)
        
        Intermediate 2 [mitochondrial inner membrane] (Mus musculus)
        
        HP subcomplex [mitochondrial inner membrane] (Mus musculus)
        
        Ndufa3 [mitochondrial inner membrane] (Mus musculus)
        
        Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Mus musculus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Mus musculus)
        
        Intermediate 2 [mitochondrial inner membrane] (Mus musculus)
        
        HP subcomplex [mitochondrial inner membrane] (Mus musculus)
        
        Ndufa3 [mitochondrial inner membrane] (Mus musculus)
        
        Intermediate 2 [mitochondrial inner membrane] (Mus musculus)
        
        HP subcomplex [mitochondrial inner membrane] (Mus musculus)
        
        Ndufa3 [mitochondrial inner membrane] (Mus musculus)
        
        ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Mus musculus)
        
        550kDa complex [mitochondrial inner membrane] (Mus musculus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Mus musculus)
        
        Intermediate 2 [mitochondrial inner membrane] (Mus musculus)
        
        HP subcomplex [mitochondrial inner membrane] (Mus musculus)
        
        Ndufa3 [mitochondrial inner membrane] (Mus musculus)
        
        815kDa complex [mitochondrial inner membrane] (Mus musculus)
        
        550kDa complex [mitochondrial inner membrane] (Mus musculus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Mus musculus)
        
        Intermediate 2 [mitochondrial inner membrane] (Mus musculus)
        
        HP subcomplex [mitochondrial inner membrane] (Mus musculus)
        
        Ndufa3 [mitochondrial inner membrane] (Mus musculus)
        
        Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Mus musculus)
        
        815kDa complex [mitochondrial inner membrane] (Mus musculus)
        
        550kDa complex [mitochondrial inner membrane] (Mus musculus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Mus musculus)
        
        Intermediate 2 [mitochondrial inner membrane] (Mus musculus)
        
        HP subcomplex [mitochondrial inner membrane] (Mus musculus)
        
        Ndufa3 [mitochondrial inner membrane] (Mus musculus)
        
        980kDa complex [mitochondrial inner membrane] (Mus musculus)
        
        815kDa complex [mitochondrial inner membrane] (Mus musculus)
        
        550kDa complex [mitochondrial inner membrane] (Mus musculus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Mus musculus)
        
        Intermediate 2 [mitochondrial inner membrane] (Mus musculus)
        
        HP subcomplex [mitochondrial inner membrane] (Mus musculus)
        
        Ndufa3 [mitochondrial inner membrane] (Mus musculus)
        
        The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Mus musculus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Mus musculus)
        
        Intermediate 2 [mitochondrial inner membrane] (Mus musculus)
        
        HP subcomplex [mitochondrial inner membrane] (Mus musculus)
        
        Ndufa3 [mitochondrial inner membrane] (Mus musculus)
        
        550kDa complex [mitochondrial inner membrane] (Mus musculus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Mus musculus)
        
        Intermediate 2 [mitochondrial inner membrane] (Mus musculus)
        
        HP subcomplex [mitochondrial inner membrane] (Mus musculus)
        
        Ndufa3 [mitochondrial inner membrane] (Mus musculus)
        
        The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Mus musculus)
        
        980kDa complex [mitochondrial inner membrane] (Mus musculus)
        
        815kDa complex [mitochondrial inner membrane] (Mus musculus)
        
        550kDa complex [mitochondrial inner membrane] (Mus musculus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Mus musculus)
        
        Intermediate 2 [mitochondrial inner membrane] (Mus musculus)
        
        HP subcomplex [mitochondrial inner membrane] (Mus musculus)
        
        Ndufa3 [mitochondrial inner membrane] (Mus musculus)
        
        Complex I [mitochondrial inner membrane] (Mus musculus)
        
        815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Mus musculus)
        
        550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Mus musculus)
        
        315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Mus musculus)
        
        Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Mus musculus)
        
        HP subcomplex [mitochondrial inner membrane] (Mus musculus)
        
        Ndufa3 [mitochondrial inner membrane] (Mus musculus)
      - Complex I oxidises NADH to NAD+, reduces CoQ to QH2 (Mus musculus)
        
        Complex I [mitochondrial inner membrane] (Mus musculus)
        
        815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Mus musculus)
        
        550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Mus musculus)
        
        315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Mus musculus)
        
        Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Mus musculus)
        
        HP subcomplex [mitochondrial inner membrane] (Mus musculus)
        
        Ndufa3 [mitochondrial inner membrane] (Mus musculus)

External Reference Information

External Reference

UniProt:Q9CQ91

Gene Names

Ndufa3

Reference Genes

BioGPS Gene:66091 Ndufa3

ENSEMBL:ENSMUSG00000035674

ENSEMBL:ENSMUSG00000035674.14 Ndufa3

KEGG Gene (Mus musculus):66091 Ndufa3

Monarch:66091 Ndufa3

NCBI Gene:66091 Ndufa3

UCSC:Q9CQ91 Ndufa3

Reference Transcript

RefSeq:NM_025348.2 Ndufa3

Other Identifiers

10549546

1428464_at

1452790_x_at

17473171

4409938

4545228

5148923

5361630

5412131

66091

96915_f_at

A_52_P69702

A_55_P2184128

GE40256

GO:0003674

GO:0005739

GO:0005743

GO:0005747

GO:0006091

GO:0007005

GO:0009060

GO:0016020

GO:0032981

GO:0042776

GO:0043226

GO:0055086

GO:0065003

GO:0070469

GO:1901135

ILMN_2772241

ILMN_2792560

aa269772_s_at

mMC011971

Participates

as a component of

HP subcomplex [mitochondrial inner membrane] (Mus musculus)

Inferred From

NDUFA3 [mitochondrial inner membrane] (Homo sapiens)

Cross References

RefSeq

NP_079624.1

Ensembl

ENSMUSP00000075953, ENSMUST00000076657, ENSMUSG00000035674

PRO

Q9CQ91

MGI

1913341

PDB

7AK6, 8OM1, 6G72, 6ZTQ, 7PSA, 6G2J, 7AK5, 7B93, 8OLT, 6ZR2

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