PITPalpha binds DCC

Stable Identifier
R-MMU-593695
Type
Reaction [binding]
Species
Mus musculus
Compartment
ReviewStatus
5/5
General
SVG |   | PPTX  | SBGN
PITPalpha binds DCC
DCC interacts directly with PITPalpha and this interaction is enhanced in the presence of Netrin-1. The interaction of DCC with PITPalpha requires the carboxy-terminal dmain of both the proteins. PITPalpha signaling pathway is important for netrin-1 mediated axon outgrowth. Netrin-1 activates PITPalpha to regulate local phosphoinositide (PI) synthesis, which is important for PI3K dependent neurite elongation.
Literature References
PubMed ID Title Journal Year
16244667 Phosphatidylinositol transfer protein-alpha in netrin-1-induced PLC signalling and neurite outgrowth

Kozlowski, D, Zhu, XJ, Ding, YQ, Wang, CL, Xiong, WC, Xie, Y, Feng, Z, Mei, L, Ackerman, SL, Navarre, S, Xi, CX, Hong, Y

Nat Cell Biol 2005
Participants
Orthologous Events
Authored
Reviewed
Created
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