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Hdac1 [nucleoplasm]
Stable Identifier
R-MMU-573340
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
nucleoplasm
Synonyms
Histone deacetylase 1, HDAC1_MOUSE, Hdac1
Locations in the PathwayBrowser
Expand all
Cell Cycle (Mus musculus)
Cell Cycle, Mitotic (Mus musculus)
Mitotic G1 phase and G1/S transition (Mus musculus)
G0 and Early G1 (Mus musculus)
Recruitment of HDAC1 by p107 (RBL1) (Mus musculus)
HDAC1:RBL1:E2F4:TFDP1,TFDP2 [nucleoplasm] (Mus musculus)
Hdac1 [nucleoplasm] (Mus musculus)
Hdac1 [nucleoplasm] (Mus musculus)
Recruitment of HDAC1 by p130 (RBL2) (Mus musculus)
HDAC1:RBL2:E2F4,E2F5:TFDP1,TFDP2 [nucleoplasm] (Mus musculus)
Hdac1 [nucleoplasm] (Mus musculus)
Hdac1 [nucleoplasm] (Mus musculus)
Chromatin organization (Mus musculus)
Chromatin modifying enzymes (Mus musculus)
HDACs deacetylate histones (Mus musculus)
HDAC1:2-containing complex binds HDAC2 Inhibitors (Mus musculus)
HDAC1:2-containing complex [nucleoplasm] (Mus musculus)
BHC complex [nucleoplasm] (Mus musculus)
Hdac1:Hdac2 [nucleoplasm] (Mus musculus)
Hdac1 [nucleoplasm] (Mus musculus)
CoREST complex [nucleoplasm] (Mus musculus)
Hdac1:Hdac2 [nucleoplasm] (Mus musculus)
Hdac1 [nucleoplasm] (Mus musculus)
NuRD complex [nucleoplasm] (Mus musculus)
Hdac1:Hdac2 [nucleoplasm] (Mus musculus)
Hdac1 [nucleoplasm] (Mus musculus)
Sin3A complex [nucleoplasm] (Mus musculus)
Sin3a core complex [nucleoplasm] (Mus musculus)
Hdac1:Hdac2 [nucleoplasm] (Mus musculus)
Hdac1 [nucleoplasm] (Mus musculus)
HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Mus musculus)
HDAC1:2-containing complex [nucleoplasm] (Mus musculus)
BHC complex [nucleoplasm] (Mus musculus)
Hdac1:Hdac2 [nucleoplasm] (Mus musculus)
Hdac1 [nucleoplasm] (Mus musculus)
CoREST complex [nucleoplasm] (Mus musculus)
Hdac1:Hdac2 [nucleoplasm] (Mus musculus)
Hdac1 [nucleoplasm] (Mus musculus)
NuRD complex [nucleoplasm] (Mus musculus)
Hdac1:Hdac2 [nucleoplasm] (Mus musculus)
Hdac1 [nucleoplasm] (Mus musculus)
Sin3A complex [nucleoplasm] (Mus musculus)
Sin3a core complex [nucleoplasm] (Mus musculus)
Hdac1:Hdac2 [nucleoplasm] (Mus musculus)
Hdac1 [nucleoplasm] (Mus musculus)
HDAC1:2-containing complex deacetylate histones (Mus musculus)
HDAC1:2-containing complex [nucleoplasm] (Mus musculus)
BHC complex [nucleoplasm] (Mus musculus)
Hdac1:Hdac2 [nucleoplasm] (Mus musculus)
Hdac1 [nucleoplasm] (Mus musculus)
CoREST complex [nucleoplasm] (Mus musculus)
Hdac1:Hdac2 [nucleoplasm] (Mus musculus)
Hdac1 [nucleoplasm] (Mus musculus)
NuRD complex [nucleoplasm] (Mus musculus)
Hdac1:Hdac2 [nucleoplasm] (Mus musculus)
Hdac1 [nucleoplasm] (Mus musculus)
Sin3A complex [nucleoplasm] (Mus musculus)
Sin3a core complex [nucleoplasm] (Mus musculus)
Hdac1:Hdac2 [nucleoplasm] (Mus musculus)
Hdac1 [nucleoplasm] (Mus musculus)
HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Mus musculus)
HDAC1:2-containing complex [nucleoplasm] (Mus musculus)
BHC complex [nucleoplasm] (Mus musculus)
Hdac1:Hdac2 [nucleoplasm] (Mus musculus)
Hdac1 [nucleoplasm] (Mus musculus)
CoREST complex [nucleoplasm] (Mus musculus)
Hdac1:Hdac2 [nucleoplasm] (Mus musculus)
Hdac1 [nucleoplasm] (Mus musculus)
NuRD complex [nucleoplasm] (Mus musculus)
Hdac1:Hdac2 [nucleoplasm] (Mus musculus)
Hdac1 [nucleoplasm] (Mus musculus)
Sin3A complex [nucleoplasm] (Mus musculus)
Sin3a core complex [nucleoplasm] (Mus musculus)
Hdac1:Hdac2 [nucleoplasm] (Mus musculus)
Hdac1 [nucleoplasm] (Mus musculus)
Gene expression (Transcription) (Mus musculus)
RNA Polymerase I Transcription (Mus musculus)
RNA Polymerase I Promoter Clearance (Mus musculus)
RNA Polymerase I Transcription Initiation (Mus musculus)
Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter (Mus musculus)
TTF-I:Sal Box:CSB:G9a:NuRD [nucleoplasm] (Mus musculus)
NuRD complex [nucleoplasm] (Mus musculus)
Hdac1:Hdac2 [nucleoplasm] (Mus musculus)
Hdac1 [nucleoplasm] (Mus musculus)
RNA Polymerase II Transcription (Mus musculus)
Generic Transcription Pathway (Mus musculus)
Notch-HLH transcription pathway (Mus musculus)
Formation of CSL NCOR corepressor complex (Mus musculus)
HDAC [nucleoplasm] (Mus musculus)
Hdac1 [nucleoplasm] (Mus musculus)
RBPJ:NCOR corepressor complex [nucleoplasm] (Mus musculus)
HDAC [nucleoplasm] (Mus musculus)
Hdac1 [nucleoplasm] (Mus musculus)
Transcriptional Regulation by MECP2 (Mus musculus)
Regulation of MECP2 expression and activity (Mus musculus)
MECP2 binds the SIN3A co-repressor complex (Mus musculus)
MECP2:SIN3A:HDAC1,HDAC2 [nucleoplasm] (Mus musculus)
MECP2:SIN3A:HDAC1 [nucleoplasm] (Mus musculus)
SIN3A:HDAC1 homodimer [nucleoplasm] (Mus musculus)
Hdac1 homodimer [nucleoplasm] (Mus musculus)
Hdac1 [nucleoplasm] (Mus musculus)
MECP2:SIN3A:HDAC1:HDAC2 [nucleoplasm] (Mus musculus)
SIN3A:HDAC1:HDAC2 [nucleoplasm] (Mus musculus)
Hdac1:Hdac2 [nucleoplasm] (Mus musculus)
Hdac1 [nucleoplasm] (Mus musculus)
SIN3A:HDAC1,HDAC2 dimers [nucleoplasm] (Mus musculus)
SIN3A:HDAC1 homodimer [nucleoplasm] (Mus musculus)
Hdac1 homodimer [nucleoplasm] (Mus musculus)
Hdac1 [nucleoplasm] (Mus musculus)
SIN3A:HDAC1:HDAC2 [nucleoplasm] (Mus musculus)
Hdac1:Hdac2 [nucleoplasm] (Mus musculus)
Hdac1 [nucleoplasm] (Mus musculus)
Transcriptional Regulation by TP53 (Mus musculus)
Regulation of TP53 Activity (Mus musculus)
Regulation of TP53 Activity through Acetylation (Mus musculus)
MTA2-NuRD complex deacetylates TP53 (Mus musculus)
MTA2-NuRD complex [nucleoplasm] (Mus musculus)
Hdac1:Hdac2 [nucleoplasm] (Mus musculus)
Hdac1 [nucleoplasm] (Mus musculus)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Mus musculus)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Mus musculus)
TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer (Mus musculus)
Hdac1 [nucleoplasm] (Mus musculus)
p-2S-SMAD2/3:SMAD4:TGIF:HDAC1 [nucleoplasm] (Mus musculus)
Hdac1 [nucleoplasm] (Mus musculus)
Transcriptional regulation by RUNX1 (Mus musculus)
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function (Mus musculus)
PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter (Mus musculus)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:GP1BA gene:H3K4me2,H3R2me2a-Nucleosome [nucleoplasm] (Mus musculus)
RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] (Mus musculus)
Hdac1 [nucleoplasm] (Mus musculus)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:GP1BA gene:H3K4me2-Nucleosome [nucleoplasm] (Mus musculus)
RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] (Mus musculus)
Hdac1 [nucleoplasm] (Mus musculus)
PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter (Mus musculus)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:ITGA2B gene:H3K4me2,H3R2me2a-Nucleosome [nucleoplasm] (Mus musculus)
RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] (Mus musculus)
Hdac1 [nucleoplasm] (Mus musculus)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:ITGA2B gene:H3K4me2-Nucleosome [nucleoplasm] (Mus musculus)
RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] (Mus musculus)
Hdac1 [nucleoplasm] (Mus musculus)
PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter (Mus musculus)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:MIR27A gene:H3K4me2,H3R2me2a-Nucleosome [nucleoplasm] (Mus musculus)
RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] (Mus musculus)
Hdac1 [nucleoplasm] (Mus musculus)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:MIR27A gene:H3K4me2-Nucleosome [nucleoplasm] (Mus musculus)
RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] (Mus musculus)
Hdac1 [nucleoplasm] (Mus musculus)
PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter (Mus musculus)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:THBS1 gene:H3K4me2-Nucleosome [nucleoplasm] (Mus musculus)
RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] (Mus musculus)
Hdac1 [nucleoplasm] (Mus musculus)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:THBS1B gene:H3K4me2,H3R2me2a-Nucleosome [nucleoplasm] (Mus musculus)
RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] (Mus musculus)
Hdac1 [nucleoplasm] (Mus musculus)
RUNX1 binds SIN3A,(SIN3B) co-repressor (Mus musculus)
Hdac1 [nucleoplasm] (Mus musculus)
RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] (Mus musculus)
Hdac1 [nucleoplasm] (Mus musculus)
Hemostasis (Mus musculus)
Factors involved in megakaryocyte development and platelet production (Mus musculus)
REST recruits the BHC complex (Mus musculus)
BHC complex [nucleoplasm] (Mus musculus)
Hdac1:Hdac2 [nucleoplasm] (Mus musculus)
Hdac1 [nucleoplasm] (Mus musculus)
BHC complex:REST:REST DNA binding sites [nucleoplasm] (Mus musculus)
BHC complex [nucleoplasm] (Mus musculus)
Hdac1:Hdac2 [nucleoplasm] (Mus musculus)
Hdac1 [nucleoplasm] (Mus musculus)
Metabolism of proteins (Mus musculus)
Post-translational protein modification (Mus musculus)
SUMOylation (Mus musculus)
SUMO E3 ligases SUMOylate target proteins (Mus musculus)
SUMOylation of chromatin organization proteins (Mus musculus)
SUMOylation of HDAC1 with SUMO1 (Mus musculus)
Hdac1 [nucleoplasm] (Mus musculus)
Signal Transduction (Mus musculus)
Intracellular signaling by second messengers (Mus musculus)
PIP3 activates AKT signaling (Mus musculus)
PTEN Regulation (Mus musculus)
Regulation of PTEN gene transcription (Mus musculus)
SALL4 recruits NuRD to PTEN gene (Mus musculus)
NuRD complex [nucleoplasm] (Mus musculus)
Hdac1:Hdac2 [nucleoplasm] (Mus musculus)
Hdac1 [nucleoplasm] (Mus musculus)
SALL4:NuRD:PTEN gene [nucleoplasm] (Mus musculus)
SALL4:NuRD [nucleoplasm] (Mus musculus)
NuRD complex [nucleoplasm] (Mus musculus)
Hdac1:Hdac2 [nucleoplasm] (Mus musculus)
Hdac1 [nucleoplasm] (Mus musculus)
Signaling by Nuclear Receptors (Mus musculus)
ESR-mediated signaling (Mus musculus)
Estrogen-dependent gene expression (Mus musculus)
FOXA1 and GATA3 bind to CCND1 promoter (Mus musculus)
CCND1 gene:H3K4me2 nucleosome:YY1:HDAC1 [nucleoplasm] (Mus musculus)
Hdac1 [nucleoplasm] (Mus musculus)
Hdac1 [nucleoplasm] (Mus musculus)
Signaling by TGFB family members (Mus musculus)
Signaling by TGF-beta Receptor Complex (Mus musculus)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Mus musculus)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Mus musculus)
TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer (Mus musculus)
Hdac1 [nucleoplasm] (Mus musculus)
p-2S-SMAD2/3:SMAD4:TGIF:HDAC1 [nucleoplasm] (Mus musculus)
Hdac1 [nucleoplasm] (Mus musculus)
Signaling by WNT (Mus musculus)
TCF dependent signaling in response to WNT (Mus musculus)
Deactivation of the beta-catenin transactivating complex (Mus musculus)
beta-catenin is replaced by repression complexes at the promoter (Mus musculus)
TCF/LEF:TLE:HDAC1 [nucleoplasm] (Mus musculus)
TLE:HDAC1 [nucleoplasm] (Mus musculus)
Hdac1 [nucleoplasm] (Mus musculus)
TLE1:HDAC1 [nucleoplasm] (Mus musculus)
Hdac1 [nucleoplasm] (Mus musculus)
Formation of the beta-catenin:TCF transactivating complex (Mus musculus)
Beta-catenin displaces TLE:HDAC1 from TCF/LEF (Mus musculus)
Hdac1 [nucleoplasm] (Mus musculus)
TCF/LEF:TLE:HDAC1 [nucleoplasm] (Mus musculus)
TLE:HDAC1 [nucleoplasm] (Mus musculus)
Hdac1 [nucleoplasm] (Mus musculus)
External Reference Information
External Reference
UniProt:O09106 Hdac1
Gene Names
Hdac1
Chain
chain:1-482
Reference Genes
BioGPS Gene:433759 Hdac1
ENSEMBL:ENSMUSG00000028800 Hdac1
KEGG Gene (Mus musculus):433759 Hdac1
Monarch:433759 Hdac1
NCBI Gene:433759 Hdac1
UCSC:O09106 Hdac1
Reference Transcript
RefSeq:NM_008228.2 Hdac1
Other Identifiers
10447004
10516605
1448246_at
17430397
433759
4554714
4771148
4777033
4853523
4912872
4914004
4944971
4976938
5003349
5028389
5030628
5034656
5080974
5090612
5104267
5107562
5111577
5216090
5316049
5374789
5416995
5465606
5470267
5518063
5583342
5587574
96046_at
A_55_P1970775
A_66_P128384
GO:0003674
GO:0004407
GO:0006464
GO:0008150
GO:0016575
GO:0016810
GO:0051276
ILMN_2733514
Msa.9756.0_f_at
mMC021215
u80780_s_at
Participates
as an input of
Nucleolar Chromatin Remodeling Complex (NoRC) binds intergenic spacer of rRNA gene (Mus musculus)
Recruitment of HDAC1 by p107 (RBL1) (Mus musculus)
Recruitment of HDAC1 by p130 (RBL2) (Mus musculus)
RUNX1 binds SIN3A,(SIN3B) co-repressor (Mus musculus)
SUMOylation of HDAC1 with SUMO1 (Mus musculus)
TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer (Mus musculus)
as a component of
CCND1 gene:H3K4me2 nucleosome:YY1:HDAC1 [nucleoplasm] (Mus musculus)
Hdac1 homodimer [nucleoplasm] (Mus musculus)
Hdac1:Hdac2 [nucleoplasm] (Mus musculus)
HDAC1:RBL1:E2F4:TFDP1,TFDP2 [nucleoplasm] (Mus musculus)
Hdac1:Rbl1:E2f4:Tfdp1,Tfdp2 [nucleoplasm] (Mus musculus)
HDAC1:RBL2:E2F4,E2F5:TFDP1,TFDP2 [nucleoplasm] (Mus musculus)
Hdac1:Rbl2:E2f4,E2f5:Tfdp1,Tfdp2 [nucleoplasm] (Mus musculus)
NoRC:pRNA:Hdac:Dnmt [nucleoplasm] (Mus musculus)
NuRD complex [nucleoplasm] (Mus musculus)
p-2S-SMAD2/3:SMAD4:TGIF:HDAC1 [nucleoplasm] (Mus musculus)
RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] (Mus musculus)
TLE1:HDAC1 [nucleoplasm] (Mus musculus)
TLE:HDAC1 [nucleoplasm] (Mus musculus)
as an output of
Beta-catenin displaces TLE:HDAC1 from TCF/LEF (Mus musculus)
FOXA1 and GATA3 bind to CCND1 promoter (Mus musculus)
as a member of
HDAC [nucleoplasm] (Mus musculus)
Other forms of this molecule
Hdac1 [nucleoplasm]
Inferred From
HDAC1 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
NP_032254.1
ZINC - Investigational
HDAC1_MOUSE
ZINC - World Drugs
HDAC1_MOUSE
ZINC - FDA approved
HDAC1_MOUSE
IntEnz
3.5.1.98
ZINC - Substances
HDAC1_MOUSE
ZINC target
O09106
Ensembl
ENSMUSG00000028800
,
ENSMUSP00000099657
,
ENSMUST00000102597
ZINC - Biogenic
HDAC1_MOUSE
PRO
O09106
MGI
108086
ZINC - Predictions - Purchasable
HDAC1_MOUSE
Interactors (18)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q60520 Sin3a
3
Sin3a [nucleoplasm]
(R-MMU-573326)
Sin3a [nucleoplasm]
(R-MMU-4086071)
Sin3a [nucleoplasm]
(R-MMU-351657)
0.773
9
UniProt:Q6ZQ88
1
Kdm1a [nucleoplasm]
(R-MMU-996769)
0.723
7
UniProt:Q9R190 Mta2
1
Mta2 [nucleoplasm]
(R-MMU-5096453)
0.708
7
UniProt:P70288 Hdac2
2
Hdac2 [nucleoplasm]
(R-MMU-573366)
Hdac2 [nucleoplasm]
(R-MMU-4615958)
0.643
5
UniProt:O88939 ZBT7A
0.641
3
UniProt:P22091 Tal1
2
Tal1 [nucleoplasm]
(R-MMU-8956511)
Tal1 [nucleoplasm]
(R-MMU-9616213)
0.564
3
UniProt:P20263
1
Pou5f1 [nucleoplasm]
(R-MMU-452472)
0.527
4
UniProt:Q8CFE3
1
Rcor1 [nucleoplasm]
(R-MMU-996766)
0.527
2
UniProt:Q61188 Ezh2
1
Ezh2 [nucleoplasm]
(R-MMU-5617899)
0.527
5
UniProt:P13864 Dnmt1
3
Dnmt1 [nucleoplasm]
(R-MMU-573310)
Dnmt1 [nucleoplasm]
(R-MMU-4655353)
Dnmt1 [nucleoplasm]
(R-MMU-212181)
0.524
3
UniProt:E9QAG8 ZN431
0.524
3
UniProt:Q02591 GSC
0.524
2
UniProt:Q04207
6
Rela [cytosol]
(R-MMU-168172)
Rela [nucleoplasm]
(R-MMU-177676)
phospho-Rela [nucleoplasm]
(R-MMU-5624468)
phospho-Rela [nucleoplasm]
(R-MMU-5660642)
Rela [nucleoplasm]
(R-MMU-8865233)
Rela [nucleoplasm]
(R-MMU-4755466)
0.499
2
UniProt:P25799
8
phospho-Nfkb1 [cytosol]
(R-MMU-451611)
phospho-Nfkb1 [cytosol]
(R-MMU-451619)
Nfkb1 [cytosol]
(R-MMU-451607)
Nfkb1 [nucleoplasm]
(R-MMU-177655)
Nfkb1 [cytosol]
(R-MMU-168168)
Nfkb1 [secretory granule lumen]
(R-MMU-6801004)
Nfkb1 [extracellular region]
(R-MMU-6806304)
Nfkb1 [specific granule lumen]
(R-MMU-6799557)
0.499
2
UniProt:P53566 Cebpa
2
Cebpa [nucleoplasm]
(R-MMU-381289)
Cebpa [nucleoplasm]
(R-MMU-442502)
0.499
2
UniProt:O54864
1
Suv39h1 [nucleoplasm]
(R-MMU-427517)
0.462
2
UniProt:Q60I23 Q60I23
0.462
2
UniProt:P48432 Sox2
2
Sox2 [nucleoplasm]
(R-MMU-452271)
Sox2 [nucleoplasm]
(R-MMU-3246072)
0.462
2
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