Reactome | Hdac1 [nucleoplasm]

Hdac1 [nucleoplasm]

Stable Identifier

R-MMU-573340

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

Histone deacetylase 1, HDAC1_MOUSE, Hdac1

Locations in the PathwayBrowser

Expand all

Hemostasis (Mus musculus)

- Factors involved in megakaryocyte development and platelet production (Mus musculus)
  - REST recruits the BHC complex (Mus musculus)
    - BHC complex [nucleoplasm] (Mus musculus)
      - Hdac1:Hdac2 [nucleoplasm] (Mus musculus)
        
        Hdac1 [nucleoplasm] (Mus musculus)
    - BHC complex:REST:REST DNA binding sites [nucleoplasm] (Mus musculus)
      - BHC complex [nucleoplasm] (Mus musculus)
        
        Hdac1:Hdac2 [nucleoplasm] (Mus musculus)
        
        Hdac1 [nucleoplasm] (Mus musculus)

Metabolism of proteins (Mus musculus)

- Post-translational protein modification (Mus musculus)
  - SUMOylation (Mus musculus)
    - SUMO E3 ligases SUMOylate target proteins (Mus musculus)
      - SUMOylation of chromatin organization proteins (Mus musculus)
        
        SUMOylation of HDAC1 with SUMO1 (Mus musculus)
        
        Hdac1 [nucleoplasm] (Mus musculus)

External Reference Information

External Reference

UniProt:O09106 Hdac1

Gene Names

Hdac1

Chain

chain:1-482

Reference Genes

BioGPS Gene:433759 Hdac1

dbSNP Gene:433759 Hdac1

ENSEMBL:ENSMUSG00000028800 Hdac1

KEGG Gene (Mus musculus):433759 Hdac1

Monarch:433759 Hdac1

NCBI Gene:433759 Hdac1

UCSC:O09106 Hdac1

Reference Transcript

RefSeq:NM_008228.2 Hdac1

Other Identifiers

10447004

10516605

1448246_at

17430397

191914

433759

4554714

4771148

4777033

4853523

4912872

4914004

4944971

4976938

5003349

5028389

5030628

5034656

5080974

5090612

5104267

5107562

5111577

5316049

5374789

5416995

5465606

5470267

5518063

5587574

96046_at

A_55_P1970775

A_66_P128384

AAB68398

AAH92070

AAI08372

BC092070

BC108371

CAA66870

CCDS18696

ENSMUSG00000028800

ENSMUSP00000099657

ENSMUST00000102597

EntrezGene:433759

GO:0000118

GO:0000122

GO:0000785

GO:0000790

GO:0000792

GO:0000976

GO:0000978

GO:0000979

GO:0001046

GO:0001085

GO:0001103

GO:0001975

GO:0002039

GO:0003674

GO:0003677

GO:0003682

GO:0003700

GO:0003714

GO:0004407

GO:0005515

GO:0005575

GO:0005634

GO:0005654

GO:0005667

GO:0005737

GO:0005829

GO:0006259

GO:0006325

GO:0006346

GO:0006357

GO:0006464

GO:0006476

GO:0006950

GO:0007492

GO:0007623

GO:0008134

GO:0008150

GO:0008284

GO:0008285

GO:0009913

GO:0010629

GO:0010870

GO:0016575

GO:0016580

GO:0016581

GO:0016787

GO:0016810

GO:0017053

GO:0019213

GO:0019899

GO:0021766

GO:0030154

GO:0030182

GO:0031000

GO:0032041

GO:0032496

GO:0032732

GO:0032760

GO:0032922

GO:0032991

GO:0033558

GO:0033613

GO:0034599

GO:0034641

GO:0035851

GO:0042475

GO:0042493

GO:0042531

GO:0042733

GO:0042826

GO:0043005

GO:0043025

GO:0043066

GO:0043124

GO:0043167

GO:0043226

GO:0043524

GO:0043922

GO:0044212

GO:0044877

GO:0045892

GO:0045893

GO:0045944

GO:0046676

GO:0046872

GO:0047485

GO:0048471

GO:0048511

GO:0048646

GO:0048714

GO:0048856

GO:0051059

GO:0052548

GO:0055093

GO:0060766

GO:0060789

GO:0061029

GO:0061198

GO:0070491

GO:0070822

GO:0070888

GO:0070932

GO:0070933

GO:0071356

GO:0090090

GO:1990841

GO:2000343

GO:2000676

GO:2000757

GO:2001243

Hdac1

Hdac1-201

ILMN_2733514

IPR000286

IPR003084

IPR023696

IPR023801

IPR037138

MGI:108086

mMC021215

Msa.9756.0_f_at

NM_008228

NP_032254

PF00850

PR01270

PR01271

Q58E49

U80780

u80780_s_at

uc008uxg.1

UPI000002791A

X98207

Participant Of

input

hasComponent

output

hasMember

HDAC [nucleoplasm]

Other forms of this molecule

SUMO1-K444,K476-HDAC1 [nucleoplasm]

Inferred From

HDAC1 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_032254.1

ZINC - World Drugs

HDAC1_MOUSE

IntEnz

3.5.1.98

ZINC - FDA approved

HDAC1_MOUSE

ZINC - Substances

HDAC1_MOUSE

ZINC target

O09106

PRO

O09106

ZINC - Predictions - Purchasable

HDAC1_MOUSE

Interactors (18)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q60520 Sin3a	3	Sin3a [nucleoplasm] (R-MMU-573326) SIN3A [nucleoplasm] (R-MMU-351657) SUMO1-SIN3A [nucleoplasm] (R-MMU-4086071)	0.773	9
UniProt:Q6ZQ88	1	KDM1A [nucleoplasm] (R-MMU-996769)	0.723	7
UniProt:Q9R190 Mta2	1	Mta2 [nucleoplasm] (R-MMU-5096453)	0.708	7
UniProt:P70288 Hdac2	2	Hdac2 [nucleoplasm] (R-MMU-573366) SUMO1-K462-HDAC2 [nucleoplasm] (R-MMU-4615958)	0.643	5
UniProt:O88939 ZBT7A			0.641	3
UniProt:P22091 Tal1	2	TAL1 [nucleoplasm] (R-MMU-8956511) Tal1 [nucleoplasm] (R-MMU-9616213)	0.564	3
UniProt:Q61188 Ezh2	1	Ezh2 [nucleoplasm] (R-MMU-5617899)	0.527	5
UniProt:P20263	1	POU5F1 [nucleoplasm] (R-MMU-452472)	0.527	4
UniProt:Q8CFE3	1	RCOR1 [nucleoplasm] (R-MMU-996766)	0.527	2
UniProt:P13864 Dnmt1	3	Dnmt1 [nucleoplasm] (R-MMU-573310) SUMO1-K-DNMT1 [nucleoplasm] (R-MMU-4655353) DNMT1 [nucleoplasm] (R-MMU-212181)	0.524	3
UniProt:E9QAG8 ZN431			0.524	3
UniProt:Q02591 GSC			0.524	2
UniProt:P25799	8	phospho-p-S927,S932-NFKB1(1-968) [cytosol] (R-MMU-451611) phospho-3xUb-p-S927,S932-NFKB1(1-968) [cytosol] (R-MMU-451619) NFKB1(1-968) [cytosol] (R-MMU-451607) NFKB1(1-433) [cytosol] (R-MMU-168168) NFKB1(1-433) [nucleoplasm] (R-MMU-177655) NFKB1(1-968) [specific granule lumen] (R-MMU-6799557) NFKB1(1-968) [extracellular region] (R-MMU-6806304) NFKB1(1-968) [secretory granule lumen] (R-MMU-6801004)	0.499	2
UniProt:P53566 Cebpa	2	CEBPA [nucleoplasm] (R-MMU-381289) Cebpa [nucleoplasm] (R-MMU-442502)	0.499	2
UniProt:Q04207	6	RELA [nucleoplasm] (R-MMU-177676) RELA [cytosol] (R-MMU-168172) phospho-p-S276-RELA [nucleoplasm] (R-MMU-5624468) phospho-p-S276,5xAcK-RELA [nucleoplasm] (R-MMU-5660642) MeK310-RELA [nucleoplasm] (R-MMU-8865233) SUMO3-K37,K122,K123-RELA [nucleoplasm] (R-MMU-4755466)	0.499	2
UniProt:O54864	1	SUV39H1 [nucleoplasm] (R-MMU-427517)	0.462	2
UniProt:Q60I23 Q60I23			0.462	2
UniProt:P48432 Sox2	2	SOX2 [nucleoplasm] (R-MMU-452271) Sox2 [nucleoplasm] (R-MMU-3246072)	0.462	2