Atg5:Atg12 binds Atg16l1

Stable Identifier
R-MMU-5682677
Type
Reaction [binding]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Atg5:Atg12 binds Atg16l1

Atg5 interacts with the small coiled?coil protein Atg16L1. The resulting Atg12-Atg5-Atg16L1 complex multimerizes through the oligomerization of Atg16l1 (Mizushima et al. 1999, 2003). The molecular weight of this multimeric complex suggests that it probably represents a tetramer of Atg12-Atg5-Atg16l1 (Kuma et al. 2002).

Literature References
PubMed ID Title Journal Year
12665549 Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate

Mizushima, N, Kuma, A, Kobayashi, Y, Yamamoto, A, Matsubae, M, Takao, T, Natsume, T, Ohsumi, Y, Yoshimori, T

J. Cell. Sci. 2003
Participants
Orthologous Events
Authored
Reviewed
Created