Atg5:Atg12 binds Atg16l1

Stable Identifier
R-MMU-5682677
Type
Reaction [binding]
Species
Mus musculus
Compartment
cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Atg5:Atg12 binds Atg16l1
Atg5 interacts with the small coiled?coil protein Atg16L1. The resulting Atg12-Atg5-Atg16L1 complex multimerizes through the oligomerization of Atg16l1 (Mizushima et al. 1999, 2003). The molecular weight of this multimeric complex suggests that it probably represents a tetramer of Atg12-Atg5-Atg16l1 (Kuma et al. 2002).
Literature References
PubMed ID Title Journal Year
12665549 Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate

Natsume, T, Kobayashi, Y, Ohsumi, Y, Mizushima, N, Takao, T, Yamamoto, A, Yoshimori, T, Kuma, A, Matsubae, M

J. Cell. Sci. 2003
Participants
Input
Output
Orthologous Events
ATG5:ATG12 binds ATG16L1 (Homo sapiens)
Authored
Jupe, S  (2015-02-02)
Reviewed
Tooze, SA  (2015-05-13)
Created
Jupe, S  (2015-03-10)
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