p-Bmal1:p-Clock,Npas2 binds F7 gene

Stable Identifier
R-MMU-5663189
Type
Reaction
Species
Mus musculus
Compartment
Summation

Bmal1:Clock (Arntl:Clock) and Bmal1:Npas2 (Arntl:Npas2) heterodimers bind E-box elements (consensus CACGTG) in the promoters of target genes. Two E-box elements separated by 6 bp are sufficient to confer circadian transcription on a reporter gene. The Factor VII (F7) promoter has an E-box and is regulated by Bmal1:Clock. Regulation by Bmal1:Npas2 has also been demonstrated, leading to the conclusion that Clock and Npas2 are at least partially redundant.

Literature References
PubMed ID Title Journal Year
18316400 Evidence for an overlapping role of CLOCK and NPAS2 transcription factors in liver circadian oscillators

Bertolucci, C, Cavallari, N, Colognesi, I, Aguzzi, J, Chen, Z, Caruso, P, FoŠ, A, Tosini, G, Bernardi, F, Pinotti, M

Mol Cell Biol 2008
Participants
Orthologous Events
Authored
Reviewed