p-Bmal1:p-Clock,Npas2 binds Nr1d1 gene

Stable Identifier
Reaction [binding]
Mus musculus
SVG |   | PPTX  | SBGN
p-Bmal1:p-Clock,Npas2 binds Nr1d1 gene

Bmal1:Clock (Arntl:Clock) and Bmal1:Npas2 (Arntl:Npas2) heterodimers bind E-box elements (consensus CACGTG) in the promoters of target genes. Two E-box elements separated by 6 bp are sufficient to confer circadian transcription on a reporter gene. The Rev-erba (Nr1d1) promoter has an E-box and is regulated by Bmal1:Clock. Regulation by Bmal1:Npas2 has also been demonstrated, leading to the conclusion that Clock and Npas2 are at least partially redundant.

Literature References
PubMed ID Title Journal Year
17417633 CLOCK and NPAS2 have overlapping roles in the suprachiasmatic circadian clock

Reppert, SM, DeBruyne, JP, Weaver, DR

Nat Neurosci 2007
15591021 The orphan receptor Rev-erbalpha gene is a target of the circadian clock pacemaker

Antoch, MP, Kakizawa, T, Safi, R, Laudet, V, Triqueneaux, G, Delaunay, F, Takahashi, JS, Thenot, S

J Mol Endocrinol 2004
12150932 The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator

Albrecht, U, Schibler, U, Preitner, N, Zakany, J, Damiola, F, Duboule, D, Lopez-Molina, L

Cell 2002
Orthologous Events
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