Csnk1a1 binds Smo dimer

Stable Identifier
R-MMU-5632658
Type
Reaction [binding]
Species
Mus musculus
Compartment
ciliary membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Csnk1a1 binds Smo dimer
Csnk1a1 binds the Smo C-terminal tail after Shh stimulation as an early step in Smo activation. Csnk1a1-mediated phosphorylation of serine residues in the S0 and S1 motifs enhances binding of both Csnk1a1 and Adrbk1/Grk2 to the C-terminal tail of Smo, increasing its phosphorylation of the and promoting an open, active conformation of the tail (Chen et al, 2010; Chen et al, 2011).
Literature References
PubMed ID Title Journal Year
21695114 Sonic Hedgehog dependent phosphorylation by CK1? and GRK2 is required for ciliary accumulation and activation of smoothened

Yue, T, Jia, J, Ma, G, Sasai, N, Briscoe, J, Jiang, J, Chen, Y

PLoS Biol. 2011
20844016 G protein-coupled receptor kinase 2 promotes high-level Hedgehog signaling by regulating the active state of Smo through kinase-dependent and kinase-independent mechanisms in Drosophila

Zhao, Y, Jia, J, Li, S, Tong, C, Liu, Y, Wang, B, Jiang, J, Chen, Y

Genes Dev. 2010
Participants
Input
Output
Orthologous Events
CSNK1A1 binds SMO dimer (Homo sapiens)
Authored
Rothfels, K  (2014-10-24)
Reviewed
Liu, Y C  (2014-11-09)
Created
Rothfels, K  (2014-10-28)
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