Shh binds Boc:Ptch1

Stable Identifier
Reaction [binding]
Mus musculus
SVG |   | PPTX  | SBGN
Shh binds Boc:Ptch1

Boc is a co-receptor for Hh signaling that binds both to Ptch1 and to Shh. Boc binding to Ptch1 is constitutive and not regulated by the interaction with Shh (Izzi et al, 2011). Binding of Boc to Shh is mediated by the third fibronectin domain of Boc, while binding of Boc to Ptch1 requires Boc fibronectin domains one and two (McLellan et al, 2008; Okada et al, 2006; Tenzen et al, 2006; Yao et al, 2006; Izzi et al, 2011). Different residues of Shh are required for interaction with Boc and Ptch1, suggesting the possibility of a ternary Shh:Boc:Ptch1 complex as depicted here, although this has not been explicitly demonstrated (Marigo et al, 1996; Stone et al, 1996; Chen and Struhl, 1996; Izzi et al, 2011; McLellan et al, 2008). Boc interacts with Ptch1 independently of Cdon and Gas1, two additional Hh coreceptors that are also required to activate Hh signaling (Izzi et al, 2011; Allen et al, 2011).

Literature References
PubMed ID Title Journal Year
8898207 Dual roles for patched in sequestering and transducing Hedgehog

Chen, Y, Struhl, G

Cell 1996
8906787 The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog

Stone, DM, Hynes, M, Armanini, M, Swanson, TA, Gu, Q, Johnson, RL, Scott, MP, Pennica, D, Goddard, A, Phillips, H, Noll, M, Hooper, JE, de Sauvage, F, Rosenthal, A

Nature 1996
16630821 The ihog cell-surface proteins bind Hedgehog and mediate pathway activation

Yao, S, Lum, L, Beachy, P

Cell 2006
8906794 Biochemical evidence that patched is the Hedgehog receptor

Marigo, V, Davey, RA, Zuo, Y, Cunningham, JM, Tabin, CJ

Nature 1996
21664577 Boc and Gas1 each form distinct Shh receptor complexes with Ptch1 and are required for Shh-mediated cell proliferation

Izzi, L, Lévesque, M, Morin, S, Laniel, D, Wilkes, BC, Mille, F, Krauss, RS, McMahon, AP, Allen, BL, Charron, F

Dev. Cell 2011
17086203 Boc is a receptor for sonic hedgehog in the guidance of commissural axons

Okada, A, Charron, F, Morin, S, Shin, DS, Wong, K, Fabre, PJ, Tessier-Lavigne, M, McConnell, SK

Nature 2006
21664576 Overlapping roles and collective requirement for the coreceptors GAS1, CDO, and BOC in SHH pathway function

Allen, BL, Song, JY, Izzi, L, Althaus, IW, Kang, JS, Charron, F, Krauss, RS, McMahon, AP

Dev. Cell 2011
18794898 The mode of Hedgehog binding to Ihog homologues is not conserved across different phyla

McLellan, JS, Zheng, X, Hauk, G, Ghirlando, R, Beachy, PA, Leahy, DJ

Nature 2008
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