Henmt1 methylates 2' hydroxyl at 3' end of piRNA in Asz1:Ddx4:Mov10l1:6xMeR-Piwil2:piRNA:Tdrd1:Tdrd12

Stable Identifier
R-MMU-5629217
Type
Reaction [transition]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Henmt1 methylates 2' hydroxyl at 3' end of piRNA in Asz1:Ddx4:Mov10l1:6xMeR-Piwil2:piRNA:Tdrd1:Tdrd12

Henmt1 transfers a methyl group from S-adenosylmethionine to the 2' hydroxyl group at the 3' end of a piRNA bound by Piwil2.

Literature References
PubMed ID Title Journal Year
21925389 3' end formation of PIWI-interacting RNAs in vitro

Kawaoka, S, Izumi, N, Katsuma, S, Tomari, Y

Mol. Cell 2011
17652135 The mouse homolog of HEN1 is a potential methylase for Piwi-interacting RNAs

Kirino, Y, Mourelatos, Z

RNA 2007
18029764 2'-O-methyl modification in mouse piRNAs and its methylase

Kirino, Y, Mourelatos, Z

Nucleic Acids Symp Ser (Oxf) 2007
Participants
Catalyst Activity

O-methyltransferase activity of Henmt1 [cytosol]

Orthologous Events
Authored
Reviewed
Created
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