Henmt1 methylates 2' hydroxyl at 3' end of piRNA in Asz1:Ddx4:Mov10l1:6xMeR-Piwil2:piRNA:Tdrd1:Tdrd12

Stable Identifier
R-MMU-5629217
Type
Reaction [transition]
Species
Mus musculus
Compartment
cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Henmt1 methylates 2' hydroxyl at 3' end of piRNA in Asz1:Ddx4:Mov10l1:6xMeR-Piwil2:piRNA:Tdrd1:Tdrd12
Henmt1 transfers a methyl group from S-adenosylmethionine to the 2' hydroxyl group at the 3' end of a piRNA bound by Piwil2.
Literature References
PubMed ID Title Journal Year
17652135 The mouse homolog of HEN1 is a potential methylase for Piwi-interacting RNAs

Kirino, Y, Mourelatos, Z

RNA 2007
21925389 3' end formation of PIWI-interacting RNAs in vitro

Kawaoka, S, Izumi, N, Katsuma, S, Tomari, Y

Mol. Cell 2011
18029764 2'-O-methyl modification in mouse piRNAs and its methylase

Kirino, Y, Mourelatos, Z

Nucleic Acids Symp Ser (Oxf) 2007
Participants
Input
Output
Catalyst Activity

O-methyltransferase activity of Henmt1 [cytosol]

Physical Entity
Henmt1 [cytosol] (Mus musculus)
Activity
O-methyltransferase activity (GO:0008171)
Orthologous Events
HENMT1 methylates 2' hydroxyl at 3' end of piRNA in 6xMeR-PIWIL2:piRNA:TDRD1:TDRD12:DDX4:ASZ:MOV10L1 (Homo sapiens)
Authored
May, B  (2014-10-25)
Reviewed
Saito, K  (2014-10-25)
Created
May, B  (2014-10-25)
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