Henmt1 methylates 2' hydroxyl at 3' end of piRNA in Asz1:Ddx4:Mov10l1:6xMeR-Piwil2:piRNA:Tdrd1:Tdrd12

Stable Identifier
R-MMU-5629217
Type
Reaction [transition]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Henmt1 methylates 2' hydroxyl at 3' end of piRNA in Asz1:Ddx4:Mov10l1:6xMeR-Piwil2:piRNA:Tdrd1:Tdrd12

Henmt1 transfers a methyl group from S-adenosylmethionine to the 2' hydroxyl group at the 3' end of a piRNA bound by Piwil2.

Literature References
PubMed ID Title Journal Year
17652135 The mouse homolog of HEN1 is a potential methylase for Piwi-interacting RNAs

Mourelatos, Z, Kirino, Y

RNA 2007
21925389 3' end formation of PIWI-interacting RNAs in vitro

Katsuma, S, Kawaoka, S, Tomari, Y, Izumi, N

Mol. Cell 2011
18029764 2'-O-methyl modification in mouse piRNAs and its methylase

Mourelatos, Z, Kirino, Y

Nucleic Acids Symp Ser (Oxf) 2007
Participants
Catalyst Activity

O-methyltransferase activity of Henmt1 [cytosol]

Orthologous Events
Authored
Reviewed
Created
Cite Us!