Mafb and Hoxb1:Pbx1:Pknox1 (Hoxb1:Pbx1:Prep1) activate Hoxa3 expression

Stable Identifier
R-MMU-5619424
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Mafb and Hoxb1:Pbx1:Pknox1 (Hoxb1:Pbx1:Prep1) activate Hoxa3 expression

The transcription factor Mafb (Kreisler, Kmrl) initially activates the Hoxa3 gene in rhombomere 5 (r5) and r6 (Manzanares et al. 1999). Weaker expression is also observed in r7. Hoxa3 autoregulates by binding and activating its own promoter (Manzanares et al. 2001).

Literature References
PubMed ID Title Journal Year
11566863 Independent regulation of initiation and maintenance phases of Hoxa3 expression in the vertebrate hindbrain involve auto- and cross-regulatory mechanisms

Maconochie, MM, Krumlauf, R, Manzanares, M, Marshall, H, Ariza-McNaughton, L, Blasi, F, Ferretti, E, Bel-Vialar, S

Development 2001
9895323 Conserved and distinct roles of kreisler in regulation of the paralogous Hoxa3 and Hoxb3 genes

Sadl, V, Krumlauf, R, Maruthainar, K, Manzanares, M, Barsh, G, Ariza-McNaughton, L, Cordes, S

Development 1999
Participants
Input
Output
Orthologous Events
MAFB (KREISLER) and HOXB1:PBX1:PKNOX1 (HOXB1:PBX1:PREP1) activate HOXA3 expression (Homo sapiens)
Authored
May, B  (2014-08-16)
Rezsohazy, R  (2015-11-15)
Reviewed
Blasi, F  (2015-05-13)
Created
May, B  (2014-08-22)
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