Reactome | RNA polymerase II polymerizes primary piRNA transcript

RNA polymerase II polymerizes primary piRNA transcript

Stable Identifier

R-MMU-5605301

Type

Reaction [omitted]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

Transcription of piRNA locus

ReviewStatus

5/5

General

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RNA polymerase II polymerizes primary piRNA transcript

Primary piRNA transcripts originate from multiple copy transposable elements and unique copy non-coding RNAs and mRNAs. As male germ cells progress from fetus to adult, the composition of piRNAs shifts from transposons to unique copy sequences (reviewed in Bortvin 2013). Using computational analyses 161 to 242 piRNA clusters and many other smaller piRNA hotspots have been identified in the mouse genome (Aravin et al. 2008, Rosenkranz and Zischler 2012, Jung et al. 2014).
The A-Myb (Mybl1) transcription factor drives transcription of both piRNA precursors and mRNAs encoding PIWI family proteins (Li et al. 2013).

Literature References

PubMed ID	Title	Journal	Year
17446352	Developmentally regulated piRNA clusters implicate MILI in transposon control Hannon, GJ, Fejes-Toth, K, Aravin, AA, Sachidanandam, R, Girard, A	Science	2007
22233380	proTRAC--a software for probabilistic piRNA cluster detection, visualization and analysis Zischler, H, Rosenkranz, D	BMC Bioinformatics	2012
24656595	piClust: A density based piRNA clustering algorithm Jung, I, Park, JC, Kim, S	Comput Biol Chem	2014
18922463	A piRNA pathway primed by individual transposons is linked to de novo DNA methylation in mice Bourc'his, D, Toth, KF, Hannon, GJ, Bestor, T, Pezic, D, Aravin, AA, Sachidanandam, R, Schaefer, C	Mol. Cell	2008
23523368	An ancient transcription factor initiates the burst of piRNA production during early meiosis in mouse testes Li, XZ, Weng, Z, Bolcun-Filas, E, Dong, X, Wang, J, Roy, CK, Zamore, PD, Schimenti, JC, Moore, MJ, Han, BW, Xu, J	Mol. Cell	2013