Reactome | GNAQ [plasma membrane]

GNAQ [plasma membrane]

Stable Identifier

R-MMU-55453

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

plasma membrane

Synonyms

P21279

Locations in the PathwayBrowser

Expand all

Hemostasis (Mus musculus)

- Platelet activation, signaling and aggregation (Mus musculus)
  - Signal amplification (Mus musculus)
    - ADP signalling through P2Y purinoceptor 1 (Mus musculus)
      - Dissociation of the P2Y purinoceptor 1:Gq complex (Mus musculus)
        
        ADP:P2RY1:G-protein Gq (active) [plasma membrane] (Mus musculus)
        
        G protein-GTP [plasma membrane] (Mus musculus)
        
        G protein alpha:GTP complex [plasma membrane] (Mus musculus)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Mus musculus)
        
        GNAQ [plasma membrane] (Mus musculus)
        
        G protein alpha:GTP complex [plasma membrane] (Mus musculus)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Mus musculus)
        
        GNAQ [plasma membrane] (Mus musculus)
      - P2Y purinoceptor 1 activates MAP kinase p38 alpha (Mus musculus)
        
        G protein alpha:GTP complex [plasma membrane] (Mus musculus)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Mus musculus)
        
        GNAQ [plasma membrane] (Mus musculus)
    - Thromboxane signalling through TP receptor (Mus musculus)
      - Activated TP receptor binds G-proten Gq (Mus musculus)
        
        Heterotrimeric G-protein Gq/11 (inactive) [plasma membrane] (Mus musculus)
        
        G-protein alpha (q/11):GDP [plasma membrane] (Mus musculus)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Mus musculus)
        
        GNAQ [plasma membrane] (Mus musculus)
        
        TP receptor:Thromboxane A2:G-protein Gq (inactive) [plasma membrane] (Mus musculus)
        
        Heterotrimeric G-protein Gq/11 (inactive) [plasma membrane] (Mus musculus)
        
        G-protein alpha (q/11):GDP [plasma membrane] (Mus musculus)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Mus musculus)
        
        GNAQ [plasma membrane] (Mus musculus)
      - Dissociation of the TP:Gq complex (Mus musculus)
        
        G protein alpha:GTP complex [plasma membrane] (Mus musculus)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Mus musculus)
        
        GNAQ [plasma membrane] (Mus musculus)
        
        TP receptor:Thromboxane A2:G-protein Gq (active) [plasma membrane] (Mus musculus)
        
        G protein-GTP [plasma membrane] (Mus musculus)
        
        G protein alpha:GTP complex [plasma membrane] (Mus musculus)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Mus musculus)
        
        GNAQ [plasma membrane] (Mus musculus)
      - Gq activation by TP receptor (Mus musculus)
        
        TP receptor:Thromboxane A2:G-protein Gq (active) [plasma membrane] (Mus musculus)
        
        G protein-GTP [plasma membrane] (Mus musculus)
        
        G protein alpha:GTP complex [plasma membrane] (Mus musculus)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Mus musculus)
        
        GNAQ [plasma membrane] (Mus musculus)
        
        TP receptor:Thromboxane A2:G-protein Gq (inactive) [plasma membrane] (Mus musculus)
        
        Heterotrimeric G-protein Gq/11 (inactive) [plasma membrane] (Mus musculus)
        
        G-protein alpha (q/11):GDP [plasma membrane] (Mus musculus)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Mus musculus)
        
        GNAQ [plasma membrane] (Mus musculus)
  - Thrombin signalling through proteinase activated receptors (PARs) (Mus musculus)
    - Thrombin-activated PARs activate Gq (Mus musculus)
      - Thrombin-activated PAR:Gq (active) [plasma membrane] (Mus musculus)
        
        G protein-GTP [plasma membrane] (Mus musculus)
        
        G protein alpha:GTP complex [plasma membrane] (Mus musculus)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Mus musculus)
        
        GNAQ [plasma membrane] (Mus musculus)
      - Thrombin-activated PARs:Gq (inactive) [plasma membrane] (Mus musculus)
        
        Heterotrimeric G-protein Gq/11 (inactive) [plasma membrane] (Mus musculus)
        
        G-protein alpha (q/11):GDP [plasma membrane] (Mus musculus)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Mus musculus)
        
        GNAQ [plasma membrane] (Mus musculus)
    - Thrombin-activated PARs binds G-protein Gq (Mus musculus)
      - Heterotrimeric G-protein Gq/11 (inactive) [plasma membrane] (Mus musculus)
        
        G-protein alpha (q/11):GDP [plasma membrane] (Mus musculus)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Mus musculus)
        
        GNAQ [plasma membrane] (Mus musculus)
      - Thrombin-activated PARs:Gq (inactive) [plasma membrane] (Mus musculus)
        
        Heterotrimeric G-protein Gq/11 (inactive) [plasma membrane] (Mus musculus)
        
        G-protein alpha (q/11):GDP [plasma membrane] (Mus musculus)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Mus musculus)
        
        GNAQ [plasma membrane] (Mus musculus)
    - Thrombin-activated PARs:Gq (active) dissociate (Mus musculus)
      - G protein alpha:GTP complex [plasma membrane] (Mus musculus)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Mus musculus)
        
        GNAQ [plasma membrane] (Mus musculus)
      - Thrombin-activated PAR:Gq (active) [plasma membrane] (Mus musculus)
        
        G protein-GTP [plasma membrane] (Mus musculus)
        
        G protein alpha:GTP complex [plasma membrane] (Mus musculus)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Mus musculus)
        
        GNAQ [plasma membrane] (Mus musculus)

External Reference Information

External Reference

UniProt:P21279 Gnaq

Gene Names

Gnaq

Chain

chain:1-359

Reference Genes

BioGPS Gene:14682 Gnaq

ENSEMBL:ENSMUSG00000024639.6 Gnaq

KEGG Gene (Mus musculus):14682 Gnaq

Monarch:14682 Gnaq

NCBI Gene:14682 Gnaq

UCSC:P21279 Gnaq

Reference Transcript

RefSeq:NM_008139.5 Gnaq

Other Identifiers

10461844

110828_at

1428938_at

1428939_s_at

1428940_at

1429559_at

1450115_at

1455729_at

14682

17357959

4512224

4665289

4722446

4905271

5028350

5180140

5285472

5337796

5341963

5361832

5386131

5449707

5476882

5532703

5568150

99981_at

A_51_P311659

A_52_P668123

A_55_P2164724

GE34495

GO:0000166

GO:0001501

GO:0001508

GO:0001664

GO:0003013

GO:0003824

GO:0003924

GO:0003925

GO:0005096

GO:0005515

GO:0005525

GO:0005634

GO:0005635

GO:0005794

GO:0005834

GO:0005886

GO:0005901

GO:0007165

GO:0007186

GO:0007189

GO:0007200

GO:0007207

GO:0007215

GO:0007507

GO:0008217

GO:0009791

GO:0010543

GO:0012501

GO:0016020

GO:0016322

GO:0016787

GO:0019001

GO:0021884

GO:0022414

GO:0023052

GO:0030154

GO:0030234

GO:0030425

GO:0031683

GO:0031965

GO:0032024

GO:0042060

GO:0042711

GO:0042733

GO:0043066

GO:0043226

GO:0043267

GO:0044297

GO:0044877

GO:0045202

GO:0045634

GO:0046872

GO:0047391

GO:0048066

GO:0048661

GO:0048856

GO:0050821

GO:0060158

GO:0060828

GO:0086100

GO:0098772

GO:0099105

GO:1904888

GO:1990806

ILMN_1230275

ILMN_1259673

ILMN_2549903

ILMN_2624023

ILMN_2658443

ILMN_2686883

M55412_s_at

mMC014857

mMC018278

mMC019019

mMR027955

Participates

as a candidate of

G(q) alpha 11,14,15,Q [plasma membrane] (Mus musculus)

as a member of

G-protein alpha (q/11/14/15) [plasma membrane] (Mus musculus)

Other forms of this molecule

Guanine nucleotide-binding protein G(q) alpha subunit [plasma membrane]

Inferred From

GNAQ [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_032165.3

Ensembl

ENSMUST00000025541, ENSMUSP00000025541, ENSMUSG00000024639

PRO

P21279

MGI

95776

PDB

4EKC, 4GNK, 4QJ3, 5DO9, 3AH8, 4QJ4, 7SQ2, 4QJ5, 2RGN, 2BCJ, 4EKD

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