Expression of Cryptochrome-1 (Cry1)

Stable Identifier
R-MMU-549359
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
General
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PNG
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Expression of Cryptochrome-1 (Cry1)
The Cryptochrome-1 (Cry1) gene is transcribed to yield mRNA and the mRNA is translated to yield protein. Cry1 mRNA shows circadian expression. An E-box element in the Cry1 promoter binds the Bmal1:Clock (Arntl:Clock) heterodimer and activates transcription.
Literature References
PubMed ID Title Journal Year
19150926 Cry1 circadian phase in vitro: wrapped up with an E-box

Hastings, MH, Dardente, H, Hazlerigg, DG, Fustin, JM, O'Neill, JS

J Biol Rhythms 2009
10428031 mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop

Kume, K, Zylka, MJ, Hastings, MH, Reppert, SM, Maywood, ES, Shearman, LP, Jin, X, Sriram, S, Weaver, DR

Cell 1999
9801304 Characterization of photolyase/blue-light receptor homologs in mouse and human cells

Kanno, S, Smit, B, Yasui, A, Kobayashi, K, Takao, M, van der Horst, GT

Nucleic Acids Res 1998
10521578 Circadian regulation of cryptochrome genes in the mouse

Sancar, A, Miyamoto, Y

Brain Res Mol Brain Res 1999
16507766 Dual role of the CLOCK/BMAL1 circadian complex in transcriptional regulation

Antoch, MP, Kondratova, AA, Gorbacheva, VY, Shamanna, RK, Kondratov, RV

FASEB J 2006
12483227 Rhythmic histone acetylation underlies transcription in the mammalian circadian clock

Wade, PA, Reppert, SM, Lee, C, Etchegaray, JP

Nature 2003
Participants
Input
Output
This event is regulated
Positively by
Regulator
p-Bmal1:p-Clock,Npas2:Cry1 gene [nucleoplasm] (Mus musculus)
Orthologous Events
Expression of CRYPTOCHROME-1 (Homo sapiens)
Authored
May, B  (2010-02-20)
Reviewed
Delaunay, F  (2010-06-23)
Kay, SA  (2010-06-23)
Hirota, T  (2010-06-23)
Albrecht, U  (2010-06-23)
Created
May, B  (2010-03-21)
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