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Recruitment of Shp-1 to pSirp alpha
Stable Identifier
R-MMU-548971
Type
Reaction [binding]
Species
Mus musculus
Compartment
cytosol
,
plasma membrane
ReviewStatus
5/5
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SIRP alpha functions as a docking protein. The tyrosine-phosphorylated residues of SIRP alpha trigger the binding and activation of tyrosine phosphatases SHP-1 and SHP-2. All four phosphotyrosines of SIRP alpha may serve as substrates for SHP-1 and SHP-2. SIRP alpha binds mostly to SHP-1 in hematopoietic cells and with SHP-2 in non-hematopoietic cells. These phosphatases mediate the specific functions of SIRP alpha.
Literature References
PubMed ID
Title
Journal
Year
9712903
High expression of inhibitory receptor SHPS-1 and its association with protein-tyrosine phosphatase SHP-1 in macrophages
Thibaudeau, E
,
Latour, S
,
Veillette, A
J Biol Chem
1998
Participants
Input
pSirpa_Mouse [plasma membrane]
(Mus musculus)
Ptpn6 [cytosol]
(Mus musculus)
Output
pSirp alpha:Shp-1 [plasma membrane]
(Mus musculus)
Orthologous Events
p-4Y-SIRPA:CD47 binds PTPN6,PTPN11 (Homo sapiens)
Authored
Garapati, P V (2009-02-12)
Reviewed
Barclay, AN (2010-05-20)
Created
Garapati, P V (2010-03-15)
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