Recruitment of Shp-1 to pSirp alpha

Stable Identifier
R-MMU-548971
Type
Reaction [binding]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Recruitment of Shp-1 to pSirp alpha

SIRP alpha functions as a docking protein. The tyrosine-phosphorylated residues of SIRP alpha trigger the binding and activation of tyrosine phosphatases SHP-1 and SHP-2. All four phosphotyrosines of SIRP alpha may serve as substrates for SHP-1 and SHP-2. SIRP alpha binds mostly to SHP-1 in hematopoietic cells and with SHP-2 in non-hematopoietic cells. These phosphatases mediate the specific functions of SIRP alpha.

Literature References
PubMed ID Title Journal Year
9712903 High expression of inhibitory receptor SHPS-1 and its association with protein-tyrosine phosphatase SHP-1 in macrophages

Veillette, A, Thibaudeau, E, Latour, S

J Biol Chem 1998
Participants
Orthologous Events
Authored
Reviewed
Created
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