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Fadd [cytosol]
Stable Identifier
R-MMU-54639
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
FADD, Q61160
Locations in the PathwayBrowser
Expand all
Immune System (Mus musculus)
Innate Immune System (Mus musculus)
Toll-like Receptor Cascades (Mus musculus)
Toll Like Receptor 4 (TLR4) Cascade (Mus musculus)
MyD88-independent TLR4 cascade (Mus musculus)
TRIF (TICAM1)-mediated TLR4 signaling (Mus musculus)
TRIF-mediated programmed cell death (Mus musculus)
Caspase-8 processing within TLR4 complex (Mus musculus)
activated TLR4:TRIF:RIP1:FADD [endosome membrane] (Mus musculus)
Fadd [cytosol] (Mus musculus)
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Mus musculus)
Fadd [cytosol] (Mus musculus)
TLR4-induced ripoptosome assembly (Mus musculus)
Fadd [cytosol] (Mus musculus)
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Mus musculus)
Fadd [cytosol] (Mus musculus)
Programmed Cell Death (Mus musculus)
Apoptosis (Mus musculus)
Caspase activation via extrinsic apoptotic signalling pathway (Mus musculus)
Caspase activation via Death Receptors in the presence of ligand (Mus musculus)
Caspase-8 processing within TLR4 complex (Mus musculus)
activated TLR4:TRIF:RIP1:FADD [endosome membrane] (Mus musculus)
Fadd [cytosol] (Mus musculus)
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Mus musculus)
Fadd [cytosol] (Mus musculus)
Dimerization of procaspase-8 (Mus musculus)
FAS-mediated dimerization of procaspase-8 (Mus musculus)
FASL:FAS receptor trimer:FADD:procaspase-8-dimer [plasma membrane] (Mus musculus)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Mus musculus)
Fadd [cytosol] (Mus musculus)
FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane] (Mus musculus)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Mus musculus)
Fadd [cytosol] (Mus musculus)
TNF-mediated dimerization of procaspase-8 (Mus musculus)
TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol] (Mus musculus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Mus musculus)
Fadd [cytosol] (Mus musculus)
TRAF2:TRADD:RIP1:FADD:2xCASP8(1-479) [cytosol] (Mus musculus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Mus musculus)
Fadd [cytosol] (Mus musculus)
TRAIL-mediated dimerization of procaspase-8 (Mus musculus)
TNFSF10:TNFRSF10A,B:FADD:2xCASP8(1-479) [plasma membrane] (Mus musculus)
TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Mus musculus)
Fadd [cytosol] (Mus musculus)
TNFSF10:TNFRSF10A,B:FADD:CASP8(1-479) [plasma membrane] (Mus musculus)
TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Mus musculus)
Fadd [cytosol] (Mus musculus)
Regulation by c-FLIP (Mus musculus)
Caspase-8 and FLIP(L) processing at DISC (Mus musculus)
DISC:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Mus musculus)
DISC [plasma membrane] (Mus musculus)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Mus musculus)
Fadd [cytosol] (Mus musculus)
TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Mus musculus)
Fadd [cytosol] (Mus musculus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Mus musculus)
Fadd [cytosol] (Mus musculus)
DISC:procaspase-8:FLIP(L) [plasma membrane] (Mus musculus)
DISC:procaspase-8 [plasma membrane] (Mus musculus)
DISC [plasma membrane] (Mus musculus)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Mus musculus)
Fadd [cytosol] (Mus musculus)
TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Mus musculus)
Fadd [cytosol] (Mus musculus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Mus musculus)
Fadd [cytosol] (Mus musculus)
FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling (Mus musculus)
FASL:FAS Receptor Trimer:FADD:pro-Caspase-8:FLIP(L) [plasma membrane] (Mus musculus)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Mus musculus)
Fadd [cytosol] (Mus musculus)
FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane] (Mus musculus)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Mus musculus)
Fadd [cytosol] (Mus musculus)
FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Mus musculus)
TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Mus musculus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Mus musculus)
Fadd [cytosol] (Mus musculus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Mus musculus)
Fadd [cytosol] (Mus musculus)
FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling (Mus musculus)
TNFSF10:TNFRSF10A,B:FADD:CASP8(1-479) [plasma membrane] (Mus musculus)
TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Mus musculus)
Fadd [cytosol] (Mus musculus)
TNFSF10:TNFRSF10A,B:FADD:CASP8(1-479):CFLAR [plasma membrane] (Mus musculus)
TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Mus musculus)
Fadd [cytosol] (Mus musculus)
Regulated Necrosis (Mus musculus)
RIPK1-mediated regulated necrosis (Mus musculus)
Regulation of necroptotic cell death (Mus musculus)
CASP8 activity is inhibited (Mus musculus)
FLIP(L) and procaspase-8 form heterodimer (Mus musculus)
DISC:procaspase-8 [plasma membrane] (Mus musculus)
DISC [plasma membrane] (Mus musculus)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Mus musculus)
Fadd [cytosol] (Mus musculus)
TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Mus musculus)
Fadd [cytosol] (Mus musculus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Mus musculus)
Fadd [cytosol] (Mus musculus)
DISC:procaspase-8:FLIP(L) [plasma membrane] (Mus musculus)
DISC:procaspase-8 [plasma membrane] (Mus musculus)
DISC [plasma membrane] (Mus musculus)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Mus musculus)
Fadd [cytosol] (Mus musculus)
TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Mus musculus)
Fadd [cytosol] (Mus musculus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Mus musculus)
Fadd [cytosol] (Mus musculus)
FLIP(S) and procaspase-8 form heterodimer (Mus musculus)
DISC:procaspase-8 [plasma membrane] (Mus musculus)
DISC [plasma membrane] (Mus musculus)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Mus musculus)
Fadd [cytosol] (Mus musculus)
TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Mus musculus)
Fadd [cytosol] (Mus musculus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Mus musculus)
Fadd [cytosol] (Mus musculus)
DISC:procaspase-8:FLIP(S) [plasma membrane] (Mus musculus)
DISC:procaspase-8 [plasma membrane] (Mus musculus)
DISC [plasma membrane] (Mus musculus)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Mus musculus)
Fadd [cytosol] (Mus musculus)
TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Mus musculus)
Fadd [cytosol] (Mus musculus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Mus musculus)
Fadd [cytosol] (Mus musculus)
RIPK1 is cleaved by CASP8 (Mus musculus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Mus musculus)
Fadd [cytosol] (Mus musculus)
TRAF2:TRADD:RIPK1(325-671):FADD [cytosol] (Mus musculus)
Fadd [cytosol] (Mus musculus)
Signal Transduction (Mus musculus)
Death Receptor Signaling (Mus musculus)
FasL/ CD95L signaling (Mus musculus)
FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 (Mus musculus)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Mus musculus)
Fadd [cytosol] (Mus musculus)
FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane] (Mus musculus)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Mus musculus)
Fadd [cytosol] (Mus musculus)
FasL:Fas binds FADD (Mus musculus)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Mus musculus)
Fadd [cytosol] (Mus musculus)
Fadd [cytosol] (Mus musculus)
TNF signaling (Mus musculus)
Regulation of TNFR1 signaling (Mus musculus)
Caspase-8 and FLIP(L) processing at TNFR signaling complex (Mus musculus)
TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Mus musculus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Mus musculus)
Fadd [cytosol] (Mus musculus)
TRADD:TRAF2:RIPK1:FADD:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Mus musculus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Mus musculus)
Fadd [cytosol] (Mus musculus)
FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Mus musculus)
TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Mus musculus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Mus musculus)
Fadd [cytosol] (Mus musculus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Mus musculus)
Fadd [cytosol] (Mus musculus)
RIPK1 is cleaved by CASP8 (Mus musculus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Mus musculus)
Fadd [cytosol] (Mus musculus)
TRAF2:TRADD:RIPK1(325-671):FADD [cytosol] (Mus musculus)
Fadd [cytosol] (Mus musculus)
RIPK1 is cleaved by CASP8:FLIP(L) (Mus musculus)
TRADD:TRAF2:RIPK1(325-671):FADD:p43/p41CASP8:p43 FLIP(L) [cytosol] (Mus musculus)
TRAF2:TRADD:RIPK1(325-671):FADD [cytosol] (Mus musculus)
Fadd [cytosol] (Mus musculus)
TRADD:TRAF2:RIPK1:FADD:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Mus musculus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Mus musculus)
Fadd [cytosol] (Mus musculus)
TNFR1-induced proapoptotic signaling (Mus musculus)
TRADD:TRAF2:RIP1 complex binds FADD (Mus musculus)
Fadd [cytosol] (Mus musculus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Mus musculus)
Fadd [cytosol] (Mus musculus)
TRAIL signaling (Mus musculus)
TRAIL:TRAIL Receptor Trimer:FADD complex binds procaspase-8 (Mus musculus)
TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Mus musculus)
Fadd [cytosol] (Mus musculus)
TNFSF10:TNFRSF10A,B:FADD:CASP8(1-479) [plasma membrane] (Mus musculus)
TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Mus musculus)
Fadd [cytosol] (Mus musculus)
TRAIL:TRAIL receptor trimers bind FADD (Mus musculus)
Fadd [cytosol] (Mus musculus)
TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Mus musculus)
Fadd [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:Q61160
Gene Names
Fadd
Reference Genes
BioGPS Gene:14082 Fadd
ENSEMBL:ENSMUSG00000031077
ENSEMBL:ENSMUSG00000031077.8 Fadd
KEGG Gene (Mus musculus):14082 Fadd
Monarch:14082 Fadd
NCBI Gene:14082 Fadd
UCSC:Q61160 Fadd
Reference Transcript
RefSeq:NM_010175.5 Fadd
Other Identifiers
100500_at
10569611
14082
1416888_at
1446499_at
17498461
4353716
4583761
4689890
4846733
5044499
5414378
A_52_P192418
GO:0001822
GO:0001916
GO:0002020
GO:0002376
GO:0002821
GO:0005123
GO:0005164
GO:0005515
GO:0005737
GO:0005829
GO:0005886
GO:0006351
GO:0006355
GO:0006915
GO:0007155
GO:0007165
GO:0008625
GO:0012501
GO:0023052
GO:0030154
GO:0030217
GO:0031264
GO:0031265
GO:0032729
GO:0032757
GO:0032760
GO:0032813
GO:0032991
GO:0033077
GO:0033612
GO:0035591
GO:0035877
GO:0036462
GO:0042104
GO:0042220
GO:0042802
GO:0042981
GO:0043029
GO:0043065
GO:0043123
GO:0044297
GO:0044877
GO:0045087
GO:0045089
GO:0045651
GO:0045862
GO:0045944
GO:0048148
GO:0048535
GO:0048536
GO:0048538
GO:0048738
GO:0048856
GO:0048870
GO:0051607
GO:0060090
GO:0060340
GO:0060544
GO:0060546
GO:0065003
GO:0070236
GO:0071260
GO:0071550
GO:0089720
GO:0097049
GO:0097190
GO:0097191
GO:0097192
GO:0097342
GO:0097527
GO:0098542
GO:1900119
GO:2000454
GO:2001238
ILMN_1223126
ILMN_2662509
ILMN_2874409
mMC013618
mMC020658
u50406_s_at
Participates
as a component of
TRAF2:TRADD:RIPK1(325-671):FADD [cytosol] (Mus musculus)
TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Mus musculus)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Mus musculus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Mus musculus)
activated TLR4:TRIF:RIP1:FADD [endosome membrane] (Mus musculus)
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Mus musculus)
as an input of
FasL:Fas binds FADD (Mus musculus)
TRAIL:TRAIL receptor trimers bind FADD (Mus musculus)
TRADD:TRAF2:RIP1 complex binds FADD (Mus musculus)
TLR4-induced ripoptosome assembly (Mus musculus)
Inferred From
FADD [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_034305.1
Ensembl
ENSMUSP00000033394
,
ENSMUSG00000031077
,
ENSMUST00000033394
PRO
Q61160
MGI
109324
PDB
1FAD
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q60855
14
K48polyUb-RIPK1 [cytosol]
(R-MMU-6783308)
PolyUb-RIPK1 [cytosol]
(R-MMU-6783197)
RIPK1 [cytosol]
(R-MMU-168651)
K63polyUb-RIPK1 [cytosol]
(R-MMU-937021)
phospho-p-S166-RIPK1 [cytosol]
(R-MMU-5218872)
phospho-p-S357-RIPK1 [cytosol]
(R-MMU-9819116)
phospho-p-S320-RIPK1 [cytosol]
(R-MMU-9815498)
phospho-K63,M1polyUb, p-T189-RIPK1 [cytosol]
(R-MMU-9817377)
polyUb-K377,K604,K634-RIPK1 [cytosol]
(R-MMU-9818391)
RIPK1(325-671) [cytosol]
(R-MMU-5212671)
RIPK1(1-324) [cytosol]
(R-MMU-5212664)
K63,M1polyUb-RIPK1 [cytosol]
(R-MMU-9793681)
phospho-K63,Met1polyUb-p-S25-RIPK1 [cytosol]
(R-MMU-9818793)
K48polyUb-K571,K604,K627-RIPK1 [cytosol]
(R-MMU-9796639)
0.886
9
UniProt:O89110
6
Casp8 [cytosol]
(R-MMU-3465404)
Casp8 [mitochondrial outer membrane]
(R-MMU-351869)
Casp8 [mitochondrial outer membrane]
(R-MMU-351828)
Casp8 [cytosol]
(R-MMU-76158)
Casp8 [cytosol]
(R-MMU-75975)
Casp8 [cytosol]
(R-MMU-57031)
0.813
6
UniProt:Q9QZL0
8
phospho-p-S199,227, K48pUb-363-RIPK3 [cytosol]
(R-MMU-9686933)
K33polyUb-K197,302,364-RIPK3 [cytosol]
(R-MMU-9794180)
OGlcNAc-T467-RIPK3 [cytosol]
(R-MMU-9687819)
RIPK3(329-518) [cytosol]
(R-MMU-9686937)
RIPK3(1-328) [cytosol]
(R-MMU-9686917)
Ub-K55,363-RIPK3 [cytosol]
(R-MMU-9688825)
phospho-p-S199,227-RIPK3 [cytosol]
(R-MMU-5218873)
RIPK3 [cytosol]
(R-MMU-450328)
0.802
6
UniProt:P25446
1
Fas [plasma membrane]
(R-MMU-66248)
0.669
3
UniProt:Q15628 TRADD
1
TRADD [cytosol]
(R-HSA-66376)
0.508
2
UniProt:Q99J83 Atg5
3
Atg5 [cytosol]
(R-MMU-936391)
Atg5 [cytosol]
(R-MMU-5683582)
Atg5 [phagocytic vesicle membrane]
(R-MMU-5205636)
0.462
2
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