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POLB [nucleoplasm]
Stable Identifier
R-MMU-53845
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
nucleoplasm
Synonyms
Q8K409
Locations in the PathwayBrowser
Expand all
DNA Repair (Mus musculus)
Base Excision Repair (Mus musculus)
Resolution of Abasic Sites (AP sites) (Mus musculus)
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway (Mus musculus)
LIG3 ligates NEIL1,NEIL2-generated single strand break (Mus musculus)
NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:SSB-dsDNA [nucleoplasm] (Mus musculus)
POLB [nucleoplasm] (Mus musculus)
NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:dsDNA [nucleoplasm] (Mus musculus)
POLB [nucleoplasm] (Mus musculus)
LIG3:XRCC1 and PNKP bind NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA (Mus musculus)
NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:SSB(3'Pi)-gap-dsDNA [nucleoplasm] (Mus musculus)
NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA [nucleoplasm] (Mus musculus)
POLB [nucleoplasm] (Mus musculus)
NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA [nucleoplasm] (Mus musculus)
POLB [nucleoplasm] (Mus musculus)
NEIL1,NEIL2 recruits POLB to incised AP site (Mus musculus)
NEIL1:NEIL2:POLB:SSB(3'Pi-5'dRP)-dsDNA [nucleoplasm] (Mus musculus)
POLB [nucleoplasm] (Mus musculus)
POLB [nucleoplasm] (Mus musculus)
PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Mus musculus)
NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:SSB(3'Pi)-gap-dsDNA [nucleoplasm] (Mus musculus)
NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA [nucleoplasm] (Mus musculus)
POLB [nucleoplasm] (Mus musculus)
NEIL1,NEIL2:POLB:LIG3:XRCC1:PNKP:SSB-gap-dsDNA [nucleoplasm] (Mus musculus)
POLB [nucleoplasm] (Mus musculus)
POLB excises the NEIL1,NEIL2-bound AP site (5'dRP) (Mus musculus)
NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA [nucleoplasm] (Mus musculus)
POLB [nucleoplasm] (Mus musculus)
NEIL1:NEIL2:POLB:SSB(3'Pi-5'dRP)-dsDNA [nucleoplasm] (Mus musculus)
POLB [nucleoplasm] (Mus musculus)
POLB [nucleoplasm] (Mus musculus)
POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution (Mus musculus)
NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:SSB-dsDNA [nucleoplasm] (Mus musculus)
POLB [nucleoplasm] (Mus musculus)
NEIL1,NEIL2:POLB:LIG3:XRCC1:PNKP:SSB-gap-dsDNA [nucleoplasm] (Mus musculus)
POLB [nucleoplasm] (Mus musculus)
POLB [nucleoplasm] (Mus musculus)
Resolution of AP sites via the multiple-nucleotide patch replacement pathway (Mus musculus)
PCNA-Dependent Long Patch Base Excision Repair (Mus musculus)
PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 (Mus musculus)
POLB [nucleoplasm] (Mus musculus)
POLB:APEX1:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Mus musculus)
POLB [nucleoplasm] (Mus musculus)
POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site (Mus musculus)
POLB:APEX1:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Mus musculus)
POLB [nucleoplasm] (Mus musculus)
POLB:APEX1:SSB(5'ddRP)-dsDNA [nucleoplasm] (Mus musculus)
POLB [nucleoplasm] (Mus musculus)
POLB-Dependent Long Patch Base Excision Repair (Mus musculus)
LIG1 binds POLB at long-patch BER site (Mus musculus)
LIG1:POLB:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Mus musculus)
POLB:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Mus musculus)
POLB [nucleoplasm] (Mus musculus)
POLB:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Mus musculus)
POLB [nucleoplasm] (Mus musculus)
LIG1 bound to POLB ligates SSB (Mus musculus)
LIG1:POLB:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Mus musculus)
POLB:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Mus musculus)
POLB [nucleoplasm] (Mus musculus)
LIG1:POLB:dsDNA [nucleoplasm] (Mus musculus)
POLB [nucleoplasm] (Mus musculus)
PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB (Mus musculus)
FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm] (Mus musculus)
POLB [nucleoplasm] (Mus musculus)
PAR-PARP1,PAR-PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm] (Mus musculus)
POLB [nucleoplasm] (Mus musculus)
PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site (Mus musculus)
PARP1,PARP2:FEN1:POLB:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Mus musculus)
POLB [nucleoplasm] (Mus musculus)
POLB:APEX1:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Mus musculus)
POLB [nucleoplasm] (Mus musculus)
PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Mus musculus)
PAR-PARP1,PAR-PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm] (Mus musculus)
POLB [nucleoplasm] (Mus musculus)
PARP1,PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm] (Mus musculus)
POLB [nucleoplasm] (Mus musculus)
POLB-mediated DNA strand displacement synthesis (Mus musculus)
PARP1,PARP2:FEN1:POLB:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Mus musculus)
POLB [nucleoplasm] (Mus musculus)
PARP1,PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm] (Mus musculus)
POLB [nucleoplasm] (Mus musculus)
POLB [nucleoplasm] (Mus musculus)
Recruitment of POLB to oxidatively damaged AP site (Mus musculus)
POLB [nucleoplasm] (Mus musculus)
POLB:APEX1:SSB(5'ddRP)-dsDNA [nucleoplasm] (Mus musculus)
POLB [nucleoplasm] (Mus musculus)
Resolution of AP sites via the single-nucleotide replacement pathway (Mus musculus)
Abasic sugar-phosphate removal via the single-nucleotide replacement pathway (Mus musculus)
Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break (Mus musculus)
POLB [nucleoplasm] (Mus musculus)
POLB:APEX1:SSB(AP->5'-dRP)-dsDNA [nucleoplasm] (Mus musculus)
POLB [nucleoplasm] (Mus musculus)
POLB:SSB-gap-dsDNA [nucleoplasm] (Mus musculus)
POLB [nucleoplasm] (Mus musculus)
Recruitment of POLB to the AP site (Mus musculus)
POLB [nucleoplasm] (Mus musculus)
POLB:APEX1:SSB(AP->5'-dRP)-dsDNA [nucleoplasm] (Mus musculus)
POLB [nucleoplasm] (Mus musculus)
LIG3-mediated DNA ligation via the single-nucleotide replacement pathway (Mus musculus)
LIG3:XRCC1:POLB:SSB-dsDNA [nucleoplasm] (Mus musculus)
POLB [nucleoplasm] (Mus musculus)
LIG3:XRCC1:POLB:dsDNA [nucleoplasm] (Mus musculus)
POLB [nucleoplasm] (Mus musculus)
Recruitment of LIG3:XRCC1 complex to the site of repair by POLB (Mus musculus)
LIG3:XRCC1:POLB:SSB-gap-dsDNA [nucleoplasm] (Mus musculus)
POLB:SSB-gap-dsDNA [nucleoplasm] (Mus musculus)
POLB [nucleoplasm] (Mus musculus)
POLB:SSB-gap-dsDNA [nucleoplasm] (Mus musculus)
POLB [nucleoplasm] (Mus musculus)
Resynthesis of excised residue by POLB (Mus musculus)
LIG3:XRCC1:POLB:SSB-dsDNA [nucleoplasm] (Mus musculus)
POLB [nucleoplasm] (Mus musculus)
LIG3:XRCC1:POLB:SSB-gap-dsDNA [nucleoplasm] (Mus musculus)
POLB:SSB-gap-dsDNA [nucleoplasm] (Mus musculus)
POLB [nucleoplasm] (Mus musculus)
POLB [nucleoplasm] (Mus musculus)
Metabolism of proteins (Mus musculus)
Post-translational protein modification (Mus musculus)
Deubiquitination (Mus musculus)
Ub-specific processing proteases (Mus musculus)
USP47 deubiquitinates POLB (Mus musculus)
USP47:POLB [nucleoplasm] (Mus musculus)
POLB [nucleoplasm] (Mus musculus)
External Reference Information
External Reference
UniProt:Q8K409
Reference Genes
BioGPS Gene:18970
ENSEMBL:ENSMUSG00000031536
Monarch:18970
NCBI Gene:18970
UCSC:Q8K409
Reference Transcript
RefSeq:NM_011130.2
Other Identifiers
10577544
1425371_at
1429469_at
1434229_a_at
1434230_at
17508063
17508080
18970
4411256
4517021
4517628
4558317
4562172
4628835
4708228
4854440
4912403
4996737
5096687
5117313
5169969
5202216
5224411
5296245
5325355
5402670
5472591
5475826
5480421
5497238
5508746
5525968
5567926
5577383
96217_at
A_52_P577910
A_52_P612693
A_55_P2501472
A_66_P108339
GE111291
GE119248
GO:0000795
GO:0001701
GO:0002376
GO:0003677
GO:0003684
GO:0003824
GO:0003887
GO:0005634
GO:0005737
GO:0005874
GO:0005876
GO:0006259
GO:0006260
GO:0006281
GO:0006284
GO:0006287
GO:0006290
GO:0006303
GO:0006310
GO:0006915
GO:0006954
GO:0006974
GO:0007435
GO:0008017
GO:0008092
GO:0008630
GO:0010332
GO:0012501
GO:0016445
GO:0016446
GO:0016740
GO:0016779
GO:0016829
GO:0019899
GO:0032991
GO:0034061
GO:0043226
GO:0045471
GO:0046872
GO:0048535
GO:0048536
GO:0048856
GO:0048872
GO:0051402
GO:0051575
GO:0055093
GO:0071707
GO:0071897
GO:0140078
GO:0140097
ILMN_1247976
ILMN_2504407
ILMN_2789425
Msa.4853.0_s_at
mMC008040
mMC019863
Participates
as a component of
USP47:POLB [nucleoplasm] (Mus musculus)
LIG3:XRCC1:POLB:dsDNA [nucleoplasm] (Mus musculus)
LIG3:XRCC1:POLB:SSB-dsDNA [nucleoplasm] (Mus musculus)
POLB:APEX1:SSB(AP->5'-dRP)-dsDNA [nucleoplasm] (Mus musculus)
POLB:SSB-gap-dsDNA [nucleoplasm] (Mus musculus)
LIG1:POLB:dsDNA [nucleoplasm] (Mus musculus)
PARP1,PARP2:FEN1:POLB:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Mus musculus)
PARP1,PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm] (Mus musculus)
PAR-PARP1,PAR-PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm] (Mus musculus)
POLB:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Mus musculus)
FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm] (Mus musculus)
POLB:APEX1:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Mus musculus)
POLB:APEX1:SSB(5'ddRP)-dsDNA [nucleoplasm] (Mus musculus)
NEIL1:NEIL2:POLB:SSB(3'Pi-5'dRP)-dsDNA [nucleoplasm] (Mus musculus)
NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA [nucleoplasm] (Mus musculus)
NEIL1,NEIL2:POLB:LIG3:XRCC1:PNKP:SSB-gap-dsDNA [nucleoplasm] (Mus musculus)
NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:dsDNA [nucleoplasm] (Mus musculus)
NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:SSB-dsDNA [nucleoplasm] (Mus musculus)
as an input of
Recruitment of POLB to the AP site (Mus musculus)
Recruitment of POLB to oxidatively damaged AP site (Mus musculus)
NEIL1,NEIL2 recruits POLB to incised AP site (Mus musculus)
as an output of
PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 (Mus musculus)
Other forms of this molecule
PolyUb-POLB [nucleoplasm]
Inferred From
POLB [nucleoplasm]
(Homo sapiens)
Cross References
ENSEMBL
ENSMUSP00000033938
,
ENSMUST00000033938
IntEnz
2.7.7.7
ZINC - Substances
DPOLB_MOUSE
ZINC target
Q8K409
PRO
Q8K409
MGI
97740
ZINC - Predictions - Purchasable
DPOLB_MOUSE
PDB
8E11
,
8E10
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