Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Shh(34-?) [extracellular region]
Stable Identifier
R-MMU-5362775
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
extracellular region
Synonyms
delipidated Shh
Locations in the PathwayBrowser
Expand all
Signal Transduction (Mus musculus)
Signaling by Hedgehog (Mus musculus)
Hedgehog 'on' state (Mus musculus)
Activation of SMO (Mus musculus)
SMO translocates to the cilium (Mus musculus)
Hh-Npp:BOC:PTCH1 [ciliary membrane] (Mus musculus)
Hh-Npp [extracellular region] (Mus musculus)
Shh(34-?) [extracellular region] (Mus musculus)
Hh-Npp:CDON:PTCH [ciliary membrane] (Mus musculus)
Hh-Npp [extracellular region] (Mus musculus)
Shh(34-?) [extracellular region] (Mus musculus)
Hh-Npp:GAS1:PTCH [ciliary membrane] (Mus musculus)
Hh-Npp [extracellular region] (Mus musculus)
Shh(34-?) [extracellular region] (Mus musculus)
Ligand-receptor interactions (Mus musculus)
HHIP binds Hedgehog (Mus musculus)
Hh-Npp [extracellular region] (Mus musculus)
Shh(34-?) [extracellular region] (Mus musculus)
Hh-Npp:HHIP [ciliary membrane] (Mus musculus)
Hh-Npp [extracellular region] (Mus musculus)
Shh(34-?) [extracellular region] (Mus musculus)
Hh-Npp binds CDON and PTCH (Mus musculus)
Hh-Npp [extracellular region] (Mus musculus)
Shh(34-?) [extracellular region] (Mus musculus)
Hh-Npp:CDON:PTCH [ciliary membrane] (Mus musculus)
Hh-Npp [extracellular region] (Mus musculus)
Shh(34-?) [extracellular region] (Mus musculus)
Hh-Npp binds GAS1 and PTCH (Mus musculus)
Hh-Npp [extracellular region] (Mus musculus)
Shh(34-?) [extracellular region] (Mus musculus)
Hh-Npp:GAS1:PTCH [ciliary membrane] (Mus musculus)
Hh-Npp [extracellular region] (Mus musculus)
Shh(34-?) [extracellular region] (Mus musculus)
External Reference Information
External Reference
UniProt:Q62226 Shh
Gene Names
Shh, Hhg1
Chain
signal peptide:1-24, chain:25-437, chain:25-198
Reference Genes
BioGPS Gene:20423 Shh
ENSEMBL:ENSMUSG00000002633.5 Shh
KEGG Gene (Mus musculus):20423 Shh
Monarch:20423 Shh
NCBI Gene:20423 Shh
UCSC:Q62226 Shh
Reference Transcript
RefSeq:NM_009170.3 Shh
Other Identifiers
101831_at
10528872
1427571_at
1436869_at
17446580
20423
4367440
4463949
4475989
4646084
4684870
4924477
5378527
5581148
A_52_P49014
GE33210
GO:0000122
GO:0000139
GO:0001525
GO:0001569
GO:0001570
GO:0001656
GO:0001658
GO:0001708
GO:0001755
GO:0001822
GO:0001841
GO:0001942
GO:0001944
GO:0001947
GO:0002052
GO:0002053
GO:0002076
GO:0002320
GO:0002376
GO:0003140
GO:0003824
GO:0005113
GO:0005509
GO:0005515
GO:0005539
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005783
GO:0005788
GO:0005789
GO:0005794
GO:0005886
GO:0006351
GO:0006355
GO:0006508
GO:0006606
GO:0006629
GO:0006886
GO:0006897
GO:0006913
GO:0007010
GO:0007155
GO:0007163
GO:0007165
GO:0007224
GO:0007267
GO:0007275
GO:0007368
GO:0007389
GO:0007398
GO:0007405
GO:0007411
GO:0007417
GO:0007442
GO:0007502
GO:0007507
GO:0007519
GO:0007596
GO:0008021
GO:0008209
GO:0008233
GO:0008270
GO:0008283
GO:0008284
GO:0009790
GO:0009888
GO:0009949
GO:0009952
GO:0009953
GO:0009986
GO:0010463
GO:0010467
GO:0010468
GO:0010628
GO:0010629
GO:0012501
GO:0014003
GO:0014706
GO:0014856
GO:0014858
GO:0014902
GO:0016020
GO:0016192
GO:0016477
GO:0016539
GO:0016540
GO:0016740
GO:0016787
GO:0021513
GO:0021521
GO:0021522
GO:0021794
GO:0021871
GO:0021904
GO:0021924
GO:0021930
GO:0021940
GO:0021978
GO:0022006
GO:0022414
GO:0023052
GO:0030154
GO:0030162
GO:0030163
GO:0030177
GO:0030178
GO:0030182
GO:0030312
GO:0030323
GO:0030324
GO:0030326
GO:0030336
GO:0030424
GO:0030425
GO:0030539
GO:0030850
GO:0030878
GO:0030900
GO:0030901
GO:0030902
GO:0031012
GO:0031016
GO:0031069
GO:0031410
GO:0032435
GO:0032901
GO:0033077
GO:0033085
GO:0033089
GO:0033092
GO:0034244
GO:0034504
GO:0035115
GO:0035116
GO:0035295
GO:0036484
GO:0042060
GO:0042098
GO:0042127
GO:0042130
GO:0042177
GO:0042307
GO:0042475
GO:0042476
GO:0042481
GO:0042733
GO:0043010
GO:0043025
GO:0043066
GO:0043226
GO:0043237
GO:0043369
GO:0043586
GO:0043587
GO:0043588
GO:0045059
GO:0045060
GO:0045109
GO:0045121
GO:0045165
GO:0045445
GO:0045471
GO:0045665
GO:0045666
GO:0045880
GO:0045893
GO:0045944
GO:0046534
GO:0046632
GO:0046638
GO:0046639
GO:0046872
GO:0048468
GO:0048513
GO:0048538
GO:0048546
GO:0048557
GO:0048568
GO:0048583
GO:0048589
GO:0048598
GO:0048617
GO:0048643
GO:0048645
GO:0048646
GO:0048663
GO:0048678
GO:0048706
GO:0048708
GO:0048709
GO:0048711
GO:0048714
GO:0048745
GO:0048754
GO:0048808
GO:0048839
GO:0048856
GO:0048859
GO:0048864
GO:0048870
GO:0050673
GO:0050679
GO:0050793
GO:0050896
GO:0051146
GO:0051155
GO:0051604
GO:0051781
GO:0060020
GO:0060021
GO:0060070
GO:0060173
GO:0060174
GO:0060251
GO:0060406
GO:0060425
GO:0060428
GO:0060438
GO:0060439
GO:0060441
GO:0060442
GO:0060445
GO:0060447
GO:0060458
GO:0060459
GO:0060463
GO:0060484
GO:0060516
GO:0060523
GO:0060662
GO:0060664
GO:0060684
GO:0060685
GO:0060738
GO:0060739
GO:0060767
GO:0060768
GO:0060769
GO:0060782
GO:0060783
GO:0060840
GO:0060916
GO:0060979
GO:0061053
GO:0061189
GO:0061196
GO:0061197
GO:0061198
GO:0070447
GO:0071285
GO:0071542
GO:0071679
GO:0072089
GO:0072091
GO:0072136
GO:0072205
GO:0090090
GO:0090162
GO:0090370
GO:0097152
GO:0097190
GO:0097264
GO:0098528
GO:0140096
GO:0140853
GO:1900180
GO:1903672
GO:1904339
GO:1905327
GO:2000062
GO:2000063
GO:2000357
GO:2000358
GO:2000729
GO:2001028
GO:2001054
ILMN_2610013
ILMN_2802979
Msa.2682.0_at
mMC005608
Participates
as an output of
Shh is released from the plasma membrane by ADAM17-mediated cleavage (Homo sapiens)
as a component of
Shh:Boc:Ptch1 [plasma membrane] (Mus musculus)
as an input of
Shh binds Boc:Ptch1 (Mus musculus)
as a member of
Hh-Npp [extracellular region] (Mus musculus)
This entity regulates
Positively
Expression of Foxf1 in lateral plate mesoderm
(Mus musculus)
Other forms of this molecule
CHOL-N-palmitoyl-L-cysteine-Shh(25-198) [plasma membrane]
Shh gene [nucleoplasm]
Shh(25-437) [endoplasmic reticulum lumen]
N4glycoAsn-2xHC-SHH(24-462) [endoplasmic reticulum lumen]
CHOL-SHH(24-197) [endoplasmic reticulum lumen]
N4glycoAsn-SHH(198-462) [endoplasmic reticulum lumen]
2xHC-SHH(24-462) [endoplasmic reticulum lumen]
ub-N4glycoAsn-SHH(198-462) [cytosol]
ub-N4glycoAsn-SHH(198-462) [endoplasmic reticulum lumen]
CHOL-N-palmitoyl-L-cysteine-SHH(24-197) [endoplasmic reticulum lumen]
CHOL-N-palmitoyl-L-cysteine-SHH(24-197) [plasma membrane]
CHOL-N-palmitoyl-L-cysteine-SHH(24-197) [extracellular region]
Inferred From
SHH(34-?) [extracellular region]
(Homo sapiens)
Cross References
RefSeq
NP_033196.1
ZINC - Metabolites
SHH_MOUSE
ZINC - World Drugs
SHH_MOUSE
ZINC - FDA approved
SHH_MOUSE
ZINC - Substances
SHH_MOUSE
ZINC target
Q62226
Ensembl
ENSMUSG00000002633
,
ENSMUSP00000002708
,
ENSMUST00000002708
ZINC - Biogenic
SHH_MOUSE
PRO
Q62226
ZINC - Predictions - Purchasable
SHH_MOUSE
MGI
98297
PDB
3N1R
,
3D1M
,
4C4N
,
2WFX
,
7RPK
,
4C4M
,
1VHH
,
2WG4
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q4KMG0 CDON
1
CDON [plasma membrane]
(R-HSA-197892)
0.76
7
UniProt:Q96QV1-1 HHIP
0.655
4
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text