Uhrf1:Chromatin binds Dnmt1

Stable Identifier
R-MMU-5336365
Type
Reaction [binding]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Uhrf1:Chromatin binds Dnmt1

Uhrf1 (also known as Np95) associates with hemimethylated CG dinucleotides in DNA (Bostick et al. 2007, Sharif et al. 2007, Arita et al. 2008, Liu et al. 2013) and dimethylated or trimethylated lysine-9 in histone H3 (H3K9me2/3) (Bostick et al. 2007, Liu et al. 2013). Uhrf1 recruits Dnmt1 to methylate cytosine residues at replication foci (Leonhardt et al. 1992), producing symmetrically methylated DNA (Bostick et al. 2007, Sharif et al. 2007, Rottach et al. 2010, Liu et al. 2013).

Literature References
PubMed ID Title Journal Year
20026581 The multi-domain protein Np95 connects DNA methylation and histone modification

Rottach, A, Frauer, C, Pichler, G, Bonapace, IM, Spada, F, Leonhardt, H

Nucleic Acids Res. 2010
17994007 The SRA protein Np95 mediates epigenetic inheritance by recruiting Dnmt1 to methylated DNA

Sharif, J, Muto, M, Takebayashi, S, Suetake, I, Iwamatsu, A, Endo, TA, Shinga, J, Mizutani-Koseki, Y, Toyoda, T, Okamura, K, Tajima, S, Mitsuya, K, Okano, M, Koseki, H

Nature 2007
23463006 UHRF1 targets DNMT1 for DNA methylation through cooperative binding of hemi-methylated DNA and methylated H3K9

Liu, X, Gao, Q, Li, P, Zhao, Q, Zhang, J, Li, J, Koseki, H, Wong, J

Nat Commun 2013
1423634 A targeting sequence directs DNA methyltransferase to sites of DNA replication in mammalian nuclei

Leonhardt, H, Page, AW, Weier, HU, Bestor, TH

Cell 1992
17673620 UHRF1 plays a role in maintaining DNA methylation in mammalian cells

Bostick, M, Kim, JK, Estève, PO, Clark, A, Pradhan, S, Jacobsen, SE

Science 2007
18772891 Recognition of hemi-methylated DNA by the SRA protein UHRF1 by a base-flipping mechanism

Arita, K, Ariyoshi, M, Tochio, H, Nakamura, Y, Shirakawa, M

Nature 2008
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