Uhrf1:Chromatin binds Dnmt1

Stable Identifier
R-MMU-5336365
Type
Reaction [binding]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Uhrf1:Chromatin binds Dnmt1
Uhrf1 (also known as Np95) associates with hemimethylated CG dinucleotides in DNA (Bostick et al. 2007, Sharif et al. 2007, Arita et al. 2008, Liu et al. 2013) and dimethylated or trimethylated lysine-9 in histone H3 (H3K9me2/3) (Bostick et al. 2007, Liu et al. 2013). Uhrf1 recruits Dnmt1 to methylate cytosine residues at replication foci (Leonhardt et al. 1992), producing symmetrically methylated DNA (Bostick et al. 2007, Sharif et al. 2007, Rottach et al. 2010, Liu et al. 2013).
Literature References
PubMed ID Title Journal Year
17994007 The SRA protein Np95 mediates epigenetic inheritance by recruiting Dnmt1 to methylated DNA

Endo, TA, Sharif, J, Muto, M, Iwamatsu, A, Mizutani-Koseki, Y, Shinga, J, Takebayashi, S, Okano, M, Suetake, I, Koseki, H, Mitsuya, K, Tajima, S, Okamura, K, Toyoda, T

Nature 2007
20026581 The multi-domain protein Np95 connects DNA methylation and histone modification

Frauer, C, Rottach, A, Leonhardt, H, Pichler, G, Spada, F, Bonapace, IM

Nucleic Acids Res. 2010
23463006 UHRF1 targets DNMT1 for DNA methylation through cooperative binding of hemi-methylated DNA and methylated H3K9

Li, J, Zhao, Q, Koseki, H, Li, P, Zhang, J, Liu, X, Gao, Q, Wong, J

Nat Commun 2013
1423634 A targeting sequence directs DNA methyltransferase to sites of DNA replication in mammalian nuclei

Leonhardt, H, Weier, HU, Bestor, TH, Page, AW

Cell 1992
17673620 UHRF1 plays a role in maintaining DNA methylation in mammalian cells

Pradhan, S, Clark, A, Jacobsen, SE, Bostick, M, Kim, JK, Estève, PO

Science 2007
18772891 Recognition of hemi-methylated DNA by the SRA protein UHRF1 by a base-flipping mechanism

Shirakawa, M, Ariyoshi, M, Arita, K, Nakamura, Y, Tochio, H

Nature 2008
Participants
Input
Output
Orthologous Events
UHRF1:Chromatin binds DNMT1 (Homo sapiens)
Authored
May, B  (2014-02-22)
Reviewed
Martín-Subero, JI  (2014-07-24)
Beekman, R  (2014-07-24)
Created
May, B  (2014-03-02)
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