Dnmt3a:Dnmt3l binds chromatin

Stable Identifier
R-MMU-5334134
Type
Reaction [binding]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Dnmt3a:Dnmt3l binds chromatin
Dnmt3l is a non-catalytic homologue of Dnmt3a and Dnmt3b which binds unmethylated lysine-4 of histone H3 (H3K4) and recruits Dnmt3a to DNA (Suetake et al. 2004, Gowher et al. 2005, Nimura et al. 2006, Hu et al. 2009, Zhang et al. 2010). Both Dnmt3l and Dnmt3a interact with unmethylated lysine-4 of histone H3 (Zhang et al. 2010, Li et al. 2011). Dnmt3l and Dnmt3a form tetramers having the subunit structure Dnmt3l:Dnmt3a:Dnmt3a:Dnmt3l (Jia et al. 2007). Dnmt3a without Dnmt3l can form oligomers (Jurkowska et al. 2011, Rajavelu et al. 2012, Jeltsch and Jurkowska 2013). Dnmt3l dissociates from the Dnmt3a:Dnmt3l complex following Dnmt3a binding to DNA. (Gowher et al. 2005).
Literature References
PubMed ID Title Journal Year
20223770 Chromatin methylation activity of Dnmt3a and Dnmt3a/3L is guided by interaction of the ADD domain with the histone H3 tail

Jurkowska, R, Rathert, P, Zhang, Y, Fischle, W, Brandt, O, Rajavelu, A, Reinhardt, R, Bock, I, Dhayalan, A, Soeroes, S, Jeltsch, A

Nucleic Acids Res. 2010
21606950 Histone tails regulate DNA methylation by allosterically activating de novo methyltransferase

Li, BZ, Li, G, Xu, GL, Chen, P, Li, E, Du, L, Song, XH, Jeltsch, A, Cui, QY, Huang, Z

Cell Res. 2011
23663978 Multimerization of the dnmt3a DNA methyltransferase and its functional implications

Jurkowska, RZ, Jeltsch, A

Prog Mol Biol Transl Sci 2013
15105426 DNMT3L stimulates the DNA methylation activity of Dnmt3a and Dnmt3b through a direct interaction

Tajima, S, Miyagawa, J, Takeshima, H, Shinozaki, F, Suetake, I

J. Biol. Chem. 2004
15671018 Mechanism of stimulation of catalytic activity of Dnmt3A and Dnmt3B DNA-(cytosine-C5)-methyltransferases by Dnmt3L

Liebert, K, Xu, G, Gowher, H, Jeltsch, A, Hermann, A

J. Biol. Chem. 2005
21566127 Oligomerization and binding of the Dnmt3a DNA methyltransferase to parallel DNA molecules: heterochromatic localization and role of Dnmt3L

Nellen, W, Urbanke, C, Anspach, N, Jurkowska, RZ, Rajavelu, A, Ragozin, S, Jeltsch, A, Jankevicius, G

J. Biol. Chem. 2011
16999741 Dnmt3a2 targets endogenous Dnmt3L to ES cell chromatin and induces regional DNA methylation

Ura, K, Ishida, C, Koriyama, H, Hata, K, Nimura, K, Kaneda, Y, Li, E, Yamanaka, S

Genes Cells 2006
17713477 Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation

Jurkowska, RZ, Zhang, X, Cheng, X, Jia, D, Jeltsch, A

Nature 2007
20018712 The N-terminus of histone H3 is required for de novo DNA methylation in chromatin

Zhang, RR, Zhang, KL, Zhou, JQ, Xu, GL, Hu, JL, Zhou, BO

Proc. Natl. Acad. Sci. U.S.A. 2009
21926161 Function and disruption of DNA methyltransferase 3a cooperative DNA binding and nucleoprotein filament formation

Fritz, J, Jurkowska, RZ, Rajavelu, A, Jeltsch, A

Nucleic Acids Res. 2012
Participants
Input
Output
Orthologous Events
DNMT3A:DNMT3L binds chromatin (Homo sapiens)
Authored
May, B  (2014-02-21)
Reviewed
Martín-Subero, JI  (2014-07-24)
Beekman, R  (2014-07-24)
Created
May, B  (2014-02-22)
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