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Ercc8 [nucleoplasm]
Stable Identifier
R-MMU-52835
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
nucleoplasm
Synonyms
ERCC8, Q8CFD5
Locations in the PathwayBrowser
Expand all
DNA Repair (Mus musculus)
Nucleotide Excision Repair (Mus musculus)
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Mus musculus)
Dual incision in TC-NER (Mus musculus)
3' incision by ERCC5 (XPG) in TC-NER (Mus musculus)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Mus musculus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
Ercc8 [nucleoplasm] (Mus musculus)
TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Mus musculus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
Ercc8 [nucleoplasm] (Mus musculus)
5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Mus musculus)
TC-NER incision complex [nucleoplasm] (Mus musculus)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
Ercc8 [nucleoplasm] (Mus musculus)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
Ercc8 [nucleoplasm] (Mus musculus)
Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Mus musculus)
TC-NER incision complex [nucleoplasm] (Mus musculus)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
Ercc8 [nucleoplasm] (Mus musculus)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
Ercc8 [nucleoplasm] (Mus musculus)
DNA polymerases delta, epsilon or kappa bind the TC-NER site (Mus musculus)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Mus musculus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
Ercc8 [nucleoplasm] (Mus musculus)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
Ercc8 [nucleoplasm] (Mus musculus)
ERCC2-facilitated RNA Pol II backtracking in TC-NER (Mus musculus)
TC-NER pre-incision complex [nucleoplasm] (Mus musculus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
Ercc8 [nucleoplasm] (Mus musculus)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
Ercc8 [nucleoplasm] (Mus musculus)
ERCC3-facilitated RNA Pol II backtracking in TC-NER (Mus musculus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
Ercc8 [nucleoplasm] (Mus musculus)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
Ercc8 [nucleoplasm] (Mus musculus)
ERCC5 and RPA bind TC-NER site (Mus musculus)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
Ercc8 [nucleoplasm] (Mus musculus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
Ercc8 [nucleoplasm] (Mus musculus)
Formation of TC-NER Pre-Incision Complex (Mus musculus)
Assembly of the pre-incision complex in TC-NER (Mus musculus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
Ercc8 [nucleoplasm] (Mus musculus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Mus musculus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
Ercc8 [nucleoplasm] (Mus musculus)
ERCC8 (CSA) binds stalled RNA Pol II (Mus musculus)
ERCC8:DDB1:CUL4:RBX1:COP9 Signalosome [nucleoplasm] (Mus musculus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
Ercc8 [nucleoplasm] (Mus musculus)
Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
Ercc8 [nucleoplasm] (Mus musculus)
ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Mus musculus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
Ercc8 [nucleoplasm] (Mus musculus)
Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
Ercc8 [nucleoplasm] (Mus musculus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
Ercc8 [nucleoplasm] (Mus musculus)
UVSSA:USP7 deubiquitinates ERCC6 (Mus musculus)
TC-NER pre-incision complex [nucleoplasm] (Mus musculus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
Ercc8 [nucleoplasm] (Mus musculus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Mus musculus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
Ercc8 [nucleoplasm] (Mus musculus)
Gap-filling DNA repair synthesis and ligation in TC-NER (Mus musculus)
Ligation of newly synthesized repair patch to incised DNA in TC-NER (Mus musculus)
TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Mus musculus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
Ercc8 [nucleoplasm] (Mus musculus)
TC-NER post-incision complex:dsDNA with transcription bubble [nucleoplasm] (Mus musculus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
Ercc8 [nucleoplasm] (Mus musculus)
Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Mus musculus)
TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Mus musculus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
Ercc8 [nucleoplasm] (Mus musculus)
TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Mus musculus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
Ercc8 [nucleoplasm] (Mus musculus)
Metabolism of proteins (Mus musculus)
Post-translational protein modification (Mus musculus)
Neddylation (Mus musculus)
AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Mus musculus)
NEDD8-AcM-UBE2M:CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUND1,2,4,5 [nucleoplasm] (Mus musculus)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22 [nucleoplasm] (Mus musculus)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Mus musculus)
DCAF protein [nucleoplasm] (Mus musculus)
Ercc8 [nucleoplasm] (Mus musculus)
NEDD8-CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [nucleoplasm] (Mus musculus)
NEDD8-CRL4 E3 ligase complex [nucleoplasm] (Mus musculus)
DCAF protein [nucleoplasm] (Mus musculus)
Ercc8 [nucleoplasm] (Mus musculus)
CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Mus musculus)
CRL4 E3 ubiquitin ligase:CAND1 [nucleoplasm] (Mus musculus)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Mus musculus)
DCAF protein [nucleoplasm] (Mus musculus)
Ercc8 [nucleoplasm] (Mus musculus)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Mus musculus)
DCAF protein [nucleoplasm] (Mus musculus)
Ercc8 [nucleoplasm] (Mus musculus)
COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex (Mus musculus)
CRL4 E3 ubiquitin ligase:CAND1 [nucleoplasm] (Mus musculus)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Mus musculus)
DCAF protein [nucleoplasm] (Mus musculus)
Ercc8 [nucleoplasm] (Mus musculus)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22 [nucleoplasm] (Mus musculus)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Mus musculus)
DCAF protein [nucleoplasm] (Mus musculus)
Ercc8 [nucleoplasm] (Mus musculus)
COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Mus musculus)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [nucleoplasm] (Mus musculus)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Mus musculus)
DCAF protein [nucleoplasm] (Mus musculus)
Ercc8 [nucleoplasm] (Mus musculus)
NEDD8-CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [nucleoplasm] (Mus musculus)
NEDD8-CRL4 E3 ligase complex [nucleoplasm] (Mus musculus)
DCAF protein [nucleoplasm] (Mus musculus)
Ercc8 [nucleoplasm] (Mus musculus)
NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex (Mus musculus)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22 [nucleoplasm] (Mus musculus)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Mus musculus)
DCAF protein [nucleoplasm] (Mus musculus)
Ercc8 [nucleoplasm] (Mus musculus)
NEDD8-AcM-UBE2M:CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUND1,2,4,5 [nucleoplasm] (Mus musculus)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22 [nucleoplasm] (Mus musculus)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Mus musculus)
DCAF protein [nucleoplasm] (Mus musculus)
Ercc8 [nucleoplasm] (Mus musculus)
External Reference Information
External Reference
UniProt:Q8CFD5
Gene Names
Ercc8
Reference Genes
BioGPS Gene:71991 Ercc8
ENSEMBL:ENSMUSG00000021694
ENSEMBL:ENSMUSG00000021694.19 Ercc8
KEGG Gene (Mus musculus):71991 Ercc8
Monarch:71991 Ercc8
NCBI Gene:71991 Ercc8
UCSC:Q8CFD5 Ercc8
Reference Transcript
RefSeq:NM_028042.3 Ercc8
Other Identifiers
10407057
108464_at
1427194_a_at
1429439_at
1432249_a_at
17289699
4336281
4426044
4437328
4473994
4562387
4669045
4678462
4957873
4997311
5006652
5023621
5077210
5096818
5204361
5308328
5318740
5437370
5449864
5595382
71991
A_51_P341010
GE123865
GO:0000012
GO:0000109
GO:0000209
GO:0003824
GO:0004842
GO:0005515
GO:0005634
GO:0006281
GO:0006283
GO:0006974
GO:0006979
GO:0009411
GO:0010165
GO:0016363
GO:0016567
GO:0016740
GO:0030163
GO:0031464
GO:0032991
GO:0036211
GO:0043161
GO:0043204
GO:0043226
GO:0044877
GO:0045739
GO:0050896
GO:0051865
GO:0080008
GO:0090262
GO:0097680
GO:0140096
ILMN_2600315
ILMN_2629069
ILMN_2719001
mMC021819
Participates
as a member of
DCAF protein [nucleoplasm] (Mus musculus)
as a component of
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
Inferred From
ERCC8 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
NP_082318.2
Ensembl
ENSMUSG00000021694
,
ENSMUSP00000059211
,
ENSMUST00000054835
PRO
Q8CFD5
MGI
1919241
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