Slc22a17 binds Lcn2, internalising it, releasing Fe3+

Stable Identifier
R-MMU-5246466
Type
Reaction [omitted]
Species
Mus musculus
Compartment
plasma membrane, extracellular region, cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Slc22a17 binds Lcn2, internalising it, releasing Fe3+
Mouse neutrophil gelatinase-associated lipocalin (Lcn2, 24p3) is a member of the lipocalin superfamily that is involved in iron trafficking both in and out of cells. The iron-bound form of Lcn2 (holo-Lcn2) is internalised following binding to the Slc22a17 receptor, leading to release of iron which increases intracellular iron concentration and subsequent inhibition of apoptosis (Devireddy et al. 2005). Mouse Lcn2 and Slc22a17 are highly homologous to their human counterparts. During infection, bacteria scavenge iron from the host cell and transfer it to the pathogen cell. Upon encountering invading bacteria, Toll-like receptors on immune cells can stimulate the transcription, translation and secretion of Lcn2. Lcn2 can then limit bacterial growth by sequestrating the iron-laden siderophore so this event is pivotal in the innate immune response to bacterial infection (Flo et al. 2004).
Literature References
PubMed ID Title Journal Year
16377569 A cell-surface receptor for lipocalin 24p3 selectively mediates apoptosis and iron uptake

Zhu, X, Gazin, C, Green, MR, Devireddy, LR

Cell 2005
15531878 Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron

Aderem, A, Rodriguez, DJ, Flo, TH, Sato, S, Strong, RK, Akira, S, Holmes, MA, Smith, KD

Nature 2004
Participants
Input
Output
Catalyst Activity

transmembrane transporter activity of Slc22a17 [plasma membrane]

Physical Entity
Slc22a17 [plasma membrane] (Mus musculus)
Activity
transmembrane transporter activity (GO:0022857)
Orthologous Events
SLC22A17 binds LCN2:2,5DHBA:Fe3+ (Homo sapiens)
Authored
Jassal, B  (2014-01-21)
Reviewed
Chen, C  (2014-06-09)
Created
Jassal, B  (2014-01-21)
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