Reactome | phospho-Shb [cytosol]

phospho-Shb [cytosol]

Stable Identifier

R-MMU-5228991

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

pS-SHB, Q6PD21

Locations in the PathwayBrowser

Expand all

Signal Transduction (Mus musculus)

- Signaling by Receptor Tyrosine Kinases (Mus musculus)
  - Signaling by VEGF (Mus musculus)
    - VEGFA-VEGFR2 Pathway (Mus musculus)
      - Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1 [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2 [plasma membrane] (Mus musculus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Mus musculus)
        
        phospho-Shb [cytosol] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:pS-SHB:p-5Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:pS-SHB:p-5Y,S732-PTK2 [plasma membrane] (Mus musculus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Mus musculus)
        
        phospho-Shb [cytosol] (Mus musculus)
      - CRK binds BCAR1 and or PXN (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1 [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2 [plasma membrane] (Mus musculus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Mus musculus)
        
        phospho-Shb [cytosol] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2 [plasma membrane] (Mus musculus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Mus musculus)
        
        phospho-Shb [cytosol] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1/p-Y31,Y118-PAX:CRK [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1 [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2 [plasma membrane] (Mus musculus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Mus musculus)
        
        phospho-Shb [cytosol] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2 [plasma membrane] (Mus musculus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Mus musculus)
        
        phospho-Shb [cytosol] (Mus musculus)
      - DOCK180:ELMO binds CRK (Mus musculus)
        
        CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1 [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2 [plasma membrane] (Mus musculus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Mus musculus)
        
        phospho-Shb [cytosol] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2 [plasma membrane] (Mus musculus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Mus musculus)
        
        phospho-Shb [cytosol] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1/p-Y31,Y118-PAX:CRK [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1 [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2 [plasma membrane] (Mus musculus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Mus musculus)
        
        phospho-Shb [cytosol] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2 [plasma membrane] (Mus musculus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Mus musculus)
        
        phospho-Shb [cytosol] (Mus musculus)
      - DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Mus musculus)
        
        CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1 [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2 [plasma membrane] (Mus musculus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Mus musculus)
        
        phospho-Shb [cytosol] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2 [plasma membrane] (Mus musculus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Mus musculus)
        
        phospho-Shb [cytosol] (Mus musculus)
      - HSP90AA1 binds p-6Y-VEGFR2 (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1 [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2 [plasma membrane] (Mus musculus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Mus musculus)
        
        phospho-Shb [cytosol] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1 [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2 [plasma membrane] (Mus musculus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Mus musculus)
        
        phospho-Shb [cytosol] (Mus musculus)
      - PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118 (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:PXN [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2 [plasma membrane] (Mus musculus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Mus musculus)
        
        phospho-Shb [cytosol] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2 [plasma membrane] (Mus musculus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Mus musculus)
        
        phospho-Shb [cytosol] (Mus musculus)
      - PTK2 autophosphorylates (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:PTK2 [plasma membrane] (Mus musculus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Mus musculus)
        
        phospho-Shb [cytosol] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2 [plasma membrane] (Mus musculus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Mus musculus)
        
        phospho-Shb [cytosol] (Mus musculus)
      - PTK2 binds p-S-SHB and is recruited to p-6Y-VEGFR2 (Mus musculus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Mus musculus)
        
        phospho-Shb [cytosol] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:PTK2 [plasma membrane] (Mus musculus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Mus musculus)
        
        phospho-Shb [cytosol] (Mus musculus)
      - PXN binds p-6Y,S732-PTK2 (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2 [plasma membrane] (Mus musculus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Mus musculus)
        
        phospho-Shb [cytosol] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:PXN [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2 [plasma membrane] (Mus musculus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Mus musculus)
        
        phospho-Shb [cytosol] (Mus musculus)
      - RHOA:GTP:Mg2+ binds ROCK1,ROCK2 (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1 [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2 [plasma membrane] (Mus musculus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Mus musculus)
        
        phospho-Shb [cytosol] (Mus musculus)
      - SRC-1 binds p-Y397-PTK2 (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2 [plasma membrane] (Mus musculus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Mus musculus)
        
        phospho-Shb [cytosol] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2:SRC-1 [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2 [plasma membrane] (Mus musculus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Mus musculus)
        
        phospho-Shb [cytosol] (Mus musculus)
      - SRC-1 phosphorylates PTK2-beta (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2:SRC-1 [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2 [plasma membrane] (Mus musculus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Mus musculus)
        
        phospho-Shb [cytosol] (Mus musculus)
      - SRC-1 phosphorylates SHB (Mus musculus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Mus musculus)
        
        phospho-Shb [cytosol] (Mus musculus)
      - SRC-1 phosphorylates p-Y397-PTK2 (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1 [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2 [plasma membrane] (Mus musculus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Mus musculus)
        
        phospho-Shb [cytosol] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2:SRC-1 [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2 [plasma membrane] (Mus musculus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Mus musculus)
        
        phospho-Shb [cytosol] (Mus musculus)
      - Src kinases phosphorylate VAV (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2:SRC-1 [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2 [plasma membrane] (Mus musculus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Mus musculus)
        
        phospho-Shb [cytosol] (Mus musculus)
      - p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407 (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2 [plasma membrane] (Mus musculus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Mus musculus)
        
        phospho-Shb [cytosol] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:pS-SHB:p-5Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:pS-SHB:p-5Y,S732-PTK2 [plasma membrane] (Mus musculus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Mus musculus)
        
        phospho-Shb [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q6PD21

Gene Names

Shb

Reference Genes

BioGPS Gene:230126 Shb

ENSEMBL:ENSMUSG00000044813

ENSEMBL:ENSMUSG00000044813.16 Shb

KEGG Gene (Mus musculus):230126 Shb

Monarch:230126 Shb

NCBI Gene:230126 Shb

UCSC:Q6PD21 Shb

Reference Transcript

RefSeq:NM_001033306.1 Shb

Other Identifiers

10512714

1434153_at

230126

4391986

4421122

4464021

4600740

4634106

4729057

5042185

5292762

5414913

5575348

A_52_P696044

A_55_P2013058

A_55_P2109701

GE114601

GO:0000278

GO:0001525

GO:0001568

GO:0001784

GO:0002376

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005886

GO:0006915

GO:0007155

GO:0012501

GO:0016020

GO:0022414

GO:0023052

GO:0030097

GO:0030154

GO:0030159

GO:0036464

GO:0042100

GO:0043226

GO:0045624

GO:0045931

GO:0048514

GO:0048856

GO:0050852

GO:0060090

GO:0071425

GO:1900194

ILMN_1216600

mMC020908

Participates

as a component of

VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Mus musculus)

Other forms of this molecule

Shb [cytosol]

Inferred From

pS-SHB [cytosol] (Homo sapiens)

Modified Residues

Name

O-phospho-L-serine at unknown position

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_001028478.1

Ensembl

ENSMUSP00000060433, ENSMUSG00000044813, ENSMUST00000061986

PRO

Q6PD21

MGI

98294

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